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Protein

Adenylate kinase isoenzyme 6

Gene

Ak6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39AMPUniRule annotation1
Binding sitei79ATPUniRule annotation1
Binding sitei105ATPUniRule annotation1
Binding sitei109ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18ATPUniRule annotation6
Nucleotide bindingi148 – 149ATPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Coilin-interacting nuclear ATPase proteinUniRule annotation
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
Gene namesi
Name:Ak6
Synonyms:Cinap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi7387335. Ak6.

Subcellular locationi

  • Nucleusnucleoplasm UniRule annotation
  • NucleusCajal body UniRule annotation

  • Note: Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001538991 – 172Adenylate kinase isoenzyme 6Add BLAST172

Proteomic databases

PaxDbiQ5EB68.

PTM databases

iPTMnetiQ5EB68.
PhosphoSitePlusiQ5EB68.

Expressioni

Gene expression databases

BgeeiENSRNOG00000039848.
ExpressionAtlasiQ5EB68. differential.
GenevisibleiQ5EB68. RN.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with COIL (via C-terminus).UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057879.

Structurei

3D structure databases

ProteinModelPortaliQ5EB68.
SMRiQ5EB68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 56NMPbindUniRule annotationAdd BLAST24
Regioni108 – 118LIDUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
GeneTreeiENSGT00390000015930.
HOGENOMiHOG000224472.
HOVERGENiHBG052207.
KOiK18532.
OMAiKFEWLDC.
OrthoDBiEOG091G0RS8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5EB68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPNILLTG TPGVGKTTLG KELASRSGLK YVNVGDLARE GHLYDGYDEE
60 70 80 90 100
YGCPILDEDR VVDELEPQMT EGGVIVDYHG CDFFPERWFH IVFVLRTDNG
110 120 130 140 150
ILYKRLETRG YHEKKLQDNI QCEIFQVLYE EAMASYKEEI VHQLPSNEPE
160 170
QLEDNINQIS KWIEQWVKDH NP
Length:172
Mass (Da):19,944
Last modified:March 15, 2005 - v1
Checksum:iA054FA201C1ED587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ323055 mRNA. Translation: ABC50104.1.
BC089989 mRNA. Translation: AAH89989.1.
RefSeqiNP_001012481.1. NM_001012463.3.
UniGeneiRn.8139.

Genome annotation databases

EnsembliENSRNOT00000061166; ENSRNOP00000057879; ENSRNOG00000039848.
GeneIDi102238592.
KEGGirno:102238592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ323055 mRNA. Translation: ABC50104.1.
BC089989 mRNA. Translation: AAH89989.1.
RefSeqiNP_001012481.1. NM_001012463.3.
UniGeneiRn.8139.

3D structure databases

ProteinModelPortaliQ5EB68.
SMRiQ5EB68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057879.

PTM databases

iPTMnetiQ5EB68.
PhosphoSitePlusiQ5EB68.

Proteomic databases

PaxDbiQ5EB68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061166; ENSRNOP00000057879; ENSRNOG00000039848.
GeneIDi102238592.
KEGGirno:102238592.

Organism-specific databases

CTDi102157402.
RGDi7387335. Ak6.

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
GeneTreeiENSGT00390000015930.
HOGENOMiHOG000224472.
HOVERGENiHBG052207.
KOiK18532.
OMAiKFEWLDC.
OrthoDBiEOG091G0RS8.

Enzyme and pathway databases

ReactomeiR-RNO-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiQ5EB68.

Gene expression databases

BgeeiENSRNOG00000039848.
ExpressionAtlasiQ5EB68. differential.
GenevisibleiQ5EB68. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAD6_RAT
AccessioniPrimary (citable) accession number: Q5EB68
Secondary accession number(s): A6XB81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.