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Protein

Adenylate kinase isoenzyme 6

Gene

Ak6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.UniRule annotation

Caution

AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.Curated

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39AMPUniRule annotation1
Binding sitei79ATPUniRule annotation1
Binding sitei105ATPUniRule annotation1
Binding sitei109ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18ATPUniRule annotation6
Nucleotide bindingi148 – 149ATPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Coilin-interacting nuclear ATPase proteinUniRule annotation
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
Gene namesi
Name:Ak6
Synonyms:Cinap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi7387335 Ak6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001538991 – 172Adenylate kinase isoenzyme 6Add BLAST172

Proteomic databases

PaxDbiQ5EB68

PTM databases

iPTMnetiQ5EB68
PhosphoSitePlusiQ5EB68

Expressioni

Gene expression databases

BgeeiENSRNOG00000039848
ExpressionAtlasiQ5EB68 baseline
GenevisibleiQ5EB68 RN

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with COIL (via C-terminus).UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057879

Structurei

3D structure databases

ProteinModelPortaliQ5EB68
SMRiQ5EB68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 56NMPbindUniRule annotationAdd BLAST24
Regioni108 – 118LIDUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3347 Eukaryota
COG1936 LUCA
GeneTreeiENSGT00390000015930
HOGENOMiHOG000224472
HOVERGENiHBG052207
KOiK18532
OMAiDNVQCEI
OrthoDBiEOG091G0RS8

Family and domain databases

HAMAPiMF_00039 Adenylate_kinase_AK6, 1 hit
InterProiView protein in InterPro
IPR020618 Adenyl_kinase_AK6
IPR027417 P-loop_NTPase
PANTHERiPTHR12595:SF0 PTHR12595:SF0, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q5EB68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPNILLTG TPGVGKTTLG KELASRSGLK YVNVGDLARE GHLYDGYDEE
60 70 80 90 100
YGCPILDEDR VVDELEPQMT EGGVIVDYHG CDFFPERWFH IVFVLRTDNG
110 120 130 140 150
ILYKRLETRG YHEKKLQDNI QCEIFQVLYE EAMASYKEEI VHQLPSNEPE
160 170
QLEDNINQIS KWIEQWVKDH NP
Length:172
Mass (Da):19,944
Last modified:March 15, 2005 - v1
Checksum:iA054FA201C1ED587
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ323055 mRNA Translation: ABC50104.1
BC089989 mRNA Translation: AAH89989.1
RefSeqiNP_001012481.1, NM_001012463.3
UniGeneiRn.8139

Genome annotation databases

EnsembliENSRNOT00000061166; ENSRNOP00000057879; ENSRNOG00000039848
GeneIDi102238592
KEGGirno:102238592

Similar proteinsi

Entry informationi

Entry nameiKAD6_RAT
AccessioniPrimary (citable) accession number: Q5EB68
Secondary accession number(s): A6XB81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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