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Protein

Solute carrier family 25 member 46

Gene

Slc25a46

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 46
Gene namesi
Name:Slc25a46
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1305072. Slc25a46.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei103 – 12321Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei202 – 22221Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei314 – 33421Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei382 – 40221Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Solute carrier family 25 member 46PRO_0000291830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei32 – 321PhosphoserineCombined sources
Modified residuei35 – 351PhosphoserineCombined sources
Modified residuei45 – 451PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5EB62.
PRIDEiQ5EB62.

PTM databases

iPTMnetiQ5EB62.
PhosphoSiteiQ5EB62.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in hindbrain, spinal cord and brain coronal sections containing corpus callosum, fornix, optic chiasm, thalamus, hypothalamus, midbrain, pons and cerebellum.1 Publication

Gene expression databases

ExpressionAtlasiQ5EB62. baseline and differential.
GenevisibleiQ5EB62. RN.

Interactioni

Subunit structurei

Interacts with IMMT.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023032.

Structurei

3D structure databases

ProteinModelPortaliQ5EB62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati96 – 18792Solcar 1Add
BLAST
Repeati311 – 416106Solcar 2Add
BLAST

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2954. Eukaryota.
ENOG410XRFB. LUCA.
GeneTreeiENSGT00390000015874.
HOGENOMiHOG000007981.
HOVERGENiHBG059752.
InParanoidiQ5EB62.
KOiK03454.
OMAiAHPCIVF.
OrthoDBiEOG7MPRDV.
PhylomeDBiQ5EB62.
TreeFamiTF313365.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EB62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPRRPEGFD GLGYRGGVRD DPAFGGPFHA RSFGSGTELG HWVTTPPDIP
60 70 80 90 100
GSRNLHWGEK SPSYGVPSAP PTLEGPAEEP FPGGGDGPRP GRSSEQLNRF
110 120 130 140 150
AGFGIGLASL FTENVLAHPC IVLRRQCQVN YHARHYHLTP FSVINIMYSF
160 170 180 190 200
NKTQGPRALW KGMGSTFIVQ GVTLGAEGII SEFTPLPREV SQKWNPKQIG
210 220 230 240 250
EHLLLKCLTY MVAMPFYSAS LIETVQSEII RDNTGILECV KEGIGRVIGL
260 270 280 290 300
GVPHSKRLLP LFSLIFPTVL HGVLHYIISS IIQKIVLLIL KRKTCSSHLA
310 320 330 340 350
ESTSPMQNML DAYFPELIAN FAASLCSDVI LYPLETVLHR LHIQGTRTII
360 370 380 390 400
DNTDLGYEVL PINTQYEGMR DCVNTIKQEE GVFGFYKGFG AVIIQYTLHA
410
TILQITKIIY STLLQNSI
Length:418
Mass (Da):46,210
Last modified:June 26, 2007 - v2
Checksum:iDF0920EFF44F4B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109497 Genomic DNA. No translation available.
BC090000 mRNA. Translation: AAH90000.1.
RefSeqiNP_001093985.1. NM_001100515.1.
UniGeneiRn.12583.

Genome annotation databases

EnsembliENSRNOT00000023032; ENSRNOP00000023032; ENSRNOG00000017091.
GeneIDi291709.
KEGGirno:291709.
UCSCiRGD:1305072. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109497 Genomic DNA. No translation available.
BC090000 mRNA. Translation: AAH90000.1.
RefSeqiNP_001093985.1. NM_001100515.1.
UniGeneiRn.12583.

3D structure databases

ProteinModelPortaliQ5EB62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023032.

PTM databases

iPTMnetiQ5EB62.
PhosphoSiteiQ5EB62.

Proteomic databases

PaxDbiQ5EB62.
PRIDEiQ5EB62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023032; ENSRNOP00000023032; ENSRNOG00000017091.
GeneIDi291709.
KEGGirno:291709.
UCSCiRGD:1305072. rat.

Organism-specific databases

CTDi91137.
RGDi1305072. Slc25a46.

Phylogenomic databases

eggNOGiKOG2954. Eukaryota.
ENOG410XRFB. LUCA.
GeneTreeiENSGT00390000015874.
HOGENOMiHOG000007981.
HOVERGENiHBG059752.
InParanoidiQ5EB62.
KOiK03454.
OMAiAHPCIVF.
OrthoDBiEOG7MPRDV.
PhylomeDBiQ5EB62.
TreeFamiTF313365.

Miscellaneous databases

PROiQ5EB62.

Gene expression databases

ExpressionAtlasiQ5EB62. baseline and differential.
GenevisibleiQ5EB62. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-418.
    Tissue: Liver.
  3. "Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system."
    Haitina T., Lindblom J., Renstroem T., Fredriksson R.
    Genomics 88:779-790(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-35 AND THR-45, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS2546_RAT
AccessioniPrimary (citable) accession number: Q5EB62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: July 6, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.