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Protein

Sugar transporter SWEET1

Gene

slc50a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates sugar transport across membranes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-DRE-189200. Cellular hexose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter SWEET1
Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Gene namesi
Name:slc50a1
Synonyms:rag1ap1
ORF Names:zgc:113092
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-050220-11. slc50a1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei38 – 58Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei63 – 83Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei98 – 118Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei125 – 145Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei156 – 176Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei189 – 209Helical; Name=7Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451191 – 219Sugar transporter SWEET1Add BLAST219

Proteomic databases

PaxDbiQ5EB14.
PRIDEiQ5EB14.

Expressioni

Gene expression databases

BgeeiENSDARG00000015158.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000025588.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 90MtN3/slv 1Add BLAST86
Domaini124 – 204MtN3/slv 2Add BLAST81

Sequence similaritiesi

Belongs to the SWEET sugar transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1623. Eukaryota.
ENOG4111M4R. LUCA.
GeneTreeiENSGT00390000007801.
HOVERGENiHBG055287.
InParanoidiQ5EB14.
KOiK15382.
OMAiFWLLVPD.
OrthoDBiEOG091G0J82.
PhylomeDBiQ5EB14.
TreeFamiTF313635.

Family and domain databases

InterProiView protein in InterPro
IPR004316. SWEET_sugar_transpr.
PfamiView protein in Pfam
PF03083. MtN3_slv. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5EB14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLQLLSCA CIIFTVGMFT TGLTDLKKMK ATQSADNVQF LPFLTTCLNN
60 70 80 90 100
LGWLYYGLLK GDGTVIFVNI IGAFLQTVYI ATYCHYTKEK RRVYTQTLLM
110 120 130 140 150
VSVLCVAWVY FSLVISPGEA QLSQLGLTCS VFTISMYLSP LADLLDIMRT
160 170 180 190 200
KSVERLSFSL TVATFFTSTS WTLYGLQLGD YYIMVPNTPG IFTSLIRFFL
210
FWWFGAVIPQ IPSYKLIQI
Length:219
Mass (Da):24,803
Last modified:July 22, 2008 - v2
Checksum:iFBFE2686A5A8095F
GO

Sequence cautioni

The sequence AAH90168 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090168 mRNA. Translation: AAH90168.1. Different initiation.
RefSeqiNP_001012515.1. NM_001012497.1.
UniGeneiDr.88651.

Genome annotation databases

EnsembliENSDART00000006093; ENSDARP00000025588; ENSDARG00000015158.
GeneIDi503533.
KEGGidre:503533.

Similar proteinsi

Entry informationi

Entry nameiSWET1_DANRE
AccessioniPrimary (citable) accession number: Q5EB14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 27, 2017
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families