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Protein

Telomeric repeat-binding factor 2-interacting protein 1

Gene

Terf2ip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-171306. Packaging Of Telomere Ends.
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Telomeric repeat-binding factor 2-interacting protein 1
Short name:
TERF2-interacting telomeric protein 1
Short name:
TRF2-interacting telomeric protein 1
Alternative name(s):
Repressor/activator protein 1 homolog
Short name:
RAP1 homolog
Gene namesi
Name:Terf2ip
Synonyms:Rap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1309684. Terf2ip.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003986412 – 393Telomeric repeat-binding factor 2-interacting protein 1Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei151PhosphoserineBy similarity1
Modified residuei153PhosphoserineBy similarity1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei200PhosphoserineCombined sources1
Modified residuei203PhosphoserineBy similarity1
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5EAN7.
PRIDEiQ5EAN7.

PTM databases

iPTMnetiQ5EAN7.
PhosphoSitePlusiQ5EAN7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010712.
GenevisibleiQ5EAN7. RN.

Interactioni

Subunit structurei

Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12. Interacts with TERF2; the interaction is direct (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014660.

Structurei

3D structure databases

ProteinModelPortaliQ5EAN7.
SMRiQ5EAN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 101BRCTAdd BLAST92
Domaini125 – 185Myb-likeAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi377 – 393Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 298Asp/Glu-rich (acidic)Add BLAST88

Sequence similaritiesi

Belongs to the RAP1 family.Curated

Phylogenomic databases

eggNOGiENOG410IJNC. Eukaryota.
ENOG4111QPC. LUCA.
GeneTreeiENSGT00390000005351.
HOGENOMiHOG000120115.
HOVERGENiHBG054209.
InParanoidiQ5EAN7.
KOiK11113.
OMAiGFEIHIT.
OrthoDBiEOG091G0NZ2.
PhylomeDBiQ5EAN7.
TreeFamiTF332348.

Family and domain databases

InterProiView protein in InterPro
IPR001357. BRCT_dom.
IPR009057. Homeobox-like.
IPR021661. Rap1_C.
IPR015010. Rap1_Myb_dom.
PfamiView protein in Pfam
PF16589. BRCT_2. 1 hit.
PF08914. Myb_DNA-bind_2. 1 hit.
PF11626. Rap1_C. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EAN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVMDLGKD PNGPTHSSTL FVREDGSAMS FYVRPSSAKR RLSTLILHGG
60 70 80 90 100
GILCRVQKPG AVLLAQPGEA LAEASGDFIS TQYILDCVER NEKLELEAYR
110 120 130 140 150
LGLTEQASDP KPGASAEGST EPEPQPLTGR IAYTDADDVA ILTYVKENAR
160 170 180 190 200
SPSSVTGNAL WKAMEKSSLT QHSWQSLKDR YLKHLQGQEH KYLLGNAPVS
210 220 230 240 250
PSSQKLKRKA EQDPEAADSG EPQNKRTPDL PEEECVKGET KENGEADNKL
260 270 280 290 300
FEEATPELGE AVVDESPDFE IHITMCDGDP PTPEEDSETQ PDEEEEEPKV
310 320 330 340 350
STQEVGTAIK IIRQLMEKFN LDLSTVTQAL LKNSGELEAT SSFLESGRRP
360 370 380 390
DGFPIWCRQD DLDLQKDDDD TRNALVKKYG AQNVARRIEF RKK
Length:393
Mass (Da):43,418
Last modified:March 15, 2005 - v1
Checksum:iEFEE754F5AA59F49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090335 mRNA. Translation: AAH90335.1.
RefSeqiNP_001013161.1. NM_001013143.1.
UniGeneiRn.2055.

Genome annotation databases

EnsembliENSRNOT00000014660; ENSRNOP00000014660; ENSRNOG00000010712.
GeneIDi307861.
KEGGirno:307861.
UCSCiRGD:1309684. rat.

Similar proteinsi

Entry informationi

Entry nameiTE2IP_RAT
AccessioniPrimary (citable) accession number: Q5EAN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 15, 2005
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families