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Protein

Telomeric repeat-binding factor 2-interacting protein 1

Gene

Terf2ip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-171306. Packaging Of Telomere Ends.
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Telomeric repeat-binding factor 2-interacting protein 1
Short name:
TERF2-interacting telomeric protein 1
Short name:
TRF2-interacting telomeric protein 1
Alternative name(s):
Repressor/activator protein 1 homolog
Short name:
RAP1 homolog
Gene namesi
Name:Terf2ip
Synonyms:Rap1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1309684. Terf2ip.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Chromosome By similarity
  • Chromosometelomere By similarity

  • Note: Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 393392Telomeric repeat-binding factor 2-interacting protein 1PRO_0000398641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei36 – 361PhosphoserineBy similarity
Cross-linki111 – 111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei151 – 1511PhosphoserineBy similarity
Modified residuei153 – 1531PhosphoserineBy similarity
Modified residuei200 – 2001PhosphoserineCombined sources
Cross-linki209 – 209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki237 – 237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5EAN7.
PRIDEiQ5EAN7.

PTM databases

iPTMnetiQ5EAN7.
PhosphoSiteiQ5EAN7.

Expressioni

Gene expression databases

GenevisibleiQ5EAN7. RN.

Interactioni

Subunit structurei

Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG (By similarity). Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2 (but not TERF1) with its C-terminus. Interacts with SLX4/BTBD12. Interacts with TERF2; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014660.

Structurei

3D structure databases

ProteinModelPortaliQ5EAN7.
SMRiQ5EAN7. Positions 129-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 10192BRCTAdd
BLAST
Domaini125 – 18561Myb-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi377 – 39317Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 29888Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the RAP1 family.Curated
Contains 1 BRCT domain.Curated
Contains 1 Myb-like domain.Curated

Phylogenomic databases

eggNOGiENOG410IJNC. Eukaryota.
ENOG4111QPC. LUCA.
GeneTreeiENSGT00390000005351.
HOGENOMiHOG000120115.
HOVERGENiHBG054209.
InParanoidiQ5EAN7.
KOiK11113.
OMAiSISFYVR.
OrthoDBiEOG7KDFBG.
PhylomeDBiQ5EAN7.
TreeFamiTF332348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR009057. Homeodomain-like.
IPR021661. Rap1_C.
IPR015010. Rap1_Myb_dom.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF08914. Myb_DNA-bind_2. 1 hit.
PF11626. Rap1_C. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EAN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVMDLGKD PNGPTHSSTL FVREDGSAMS FYVRPSSAKR RLSTLILHGG
60 70 80 90 100
GILCRVQKPG AVLLAQPGEA LAEASGDFIS TQYILDCVER NEKLELEAYR
110 120 130 140 150
LGLTEQASDP KPGASAEGST EPEPQPLTGR IAYTDADDVA ILTYVKENAR
160 170 180 190 200
SPSSVTGNAL WKAMEKSSLT QHSWQSLKDR YLKHLQGQEH KYLLGNAPVS
210 220 230 240 250
PSSQKLKRKA EQDPEAADSG EPQNKRTPDL PEEECVKGET KENGEADNKL
260 270 280 290 300
FEEATPELGE AVVDESPDFE IHITMCDGDP PTPEEDSETQ PDEEEEEPKV
310 320 330 340 350
STQEVGTAIK IIRQLMEKFN LDLSTVTQAL LKNSGELEAT SSFLESGRRP
360 370 380 390
DGFPIWCRQD DLDLQKDDDD TRNALVKKYG AQNVARRIEF RKK
Length:393
Mass (Da):43,418
Last modified:March 15, 2005 - v1
Checksum:iEFEE754F5AA59F49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090335 mRNA. Translation: AAH90335.1.
RefSeqiNP_001013161.1. NM_001013143.1.
UniGeneiRn.2055.

Genome annotation databases

EnsembliENSRNOT00000014660; ENSRNOP00000014660; ENSRNOG00000010712.
GeneIDi307861.
KEGGirno:307861.
UCSCiRGD:1309684. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090335 mRNA. Translation: AAH90335.1.
RefSeqiNP_001013161.1. NM_001013143.1.
UniGeneiRn.2055.

3D structure databases

ProteinModelPortaliQ5EAN7.
SMRiQ5EAN7. Positions 129-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014660.

PTM databases

iPTMnetiQ5EAN7.
PhosphoSiteiQ5EAN7.

Proteomic databases

PaxDbiQ5EAN7.
PRIDEiQ5EAN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014660; ENSRNOP00000014660; ENSRNOG00000010712.
GeneIDi307861.
KEGGirno:307861.
UCSCiRGD:1309684. rat.

Organism-specific databases

CTDi54386.
RGDi1309684. Terf2ip.

Phylogenomic databases

eggNOGiENOG410IJNC. Eukaryota.
ENOG4111QPC. LUCA.
GeneTreeiENSGT00390000005351.
HOGENOMiHOG000120115.
HOVERGENiHBG054209.
InParanoidiQ5EAN7.
KOiK11113.
OMAiSISFYVR.
OrthoDBiEOG7KDFBG.
PhylomeDBiQ5EAN7.
TreeFamiTF332348.

Enzyme and pathway databases

ReactomeiR-RNO-171306. Packaging Of Telomere Ends.
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.

Miscellaneous databases

PROiQ5EAN7.

Gene expression databases

GenevisibleiQ5EAN7. RN.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR009057. Homeodomain-like.
IPR021661. Rap1_C.
IPR015010. Rap1_Myb_dom.
[Graphical view]
PfamiPF16589. BRCT_2. 1 hit.
PF08914. Myb_DNA-bind_2. 1 hit.
PF11626. Rap1_C. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTE2IP_RAT
AccessioniPrimary (citable) accession number: Q5EAN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.