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Protein

Inhibitor of nuclear factor kappa-B kinase-interacting protein

Gene

Ikbip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Target of p53/TP53 with pro-apoptotic function.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of nuclear factor kappa-B kinase-interacting protein
Short name:
I kappa-B kinase-interacting protein
Short name:
IKBKB-interacting protein
Short name:
IKK-interacting protein
Gene namesi
Name:Ikbip
Synonyms:Ikip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1305457. Ikbip.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 5917HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: HGNC
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Inhibitor of nuclear factor kappa-B kinase-interacting proteinPRO_0000342263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated at Asn-151.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5EAJ6.
PRIDEiQ5EAJ6.

Expressioni

Gene expression databases

GenevisibleiQ5EAJ6. RN.

Interactioni

Protein-protein interaction databases

BioGridi260816. 1 interaction.
STRINGi10116.ENSRNOP00000010913.

Structurei

3D structure databases

ProteinModelPortaliQ5EAJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili64 – 257194Sequence analysisAdd
BLAST
Coiled coili290 – 32536Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJN2. Eukaryota.
ENOG410YFQ8. LUCA.
GeneTreeiENSGT00500000045001.
HOGENOMiHOG000113024.
HOVERGENiHBG108000.
InParanoidiQ5EAJ6.
OMAiEECKTHL.
OrthoDBiEOG7673B1.
PhylomeDBiQ5EAJ6.
TreeFamiTF331715.

Family and domain databases

InterProiIPR024152. Inh_kappa-B_kinase-int.
[Graphical view]
PANTHERiPTHR21734. PTHR21734. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5EAJ6-1) [UniParc]FASTAAdd to basket

Also known as: Ikip1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVKSRKKP GPKVAAPEPE KRSDGRKNPE ARGGAGWADP RTGLSLLSLA
60 70 80 90 100
TSLGLAWLVF QQSEKFAKVE NQYRLLQTES SEFQGLQSKI SLISNKLEST
110 120 130 140 150
ENTLQEATSS MSLMTQFEQE VAGLQRSIHD IENSEEMLTQ KLQNLNEKFQ
160 170 180 190 200
NITDLWKRTL VEMSDNTAVF KSEAKSTHSE VTLKINSAEQ EIKLLTERLK
210 220 230 240 250
DLEDSTLRNI RTVSRQEEED LLRVEAQLSS DTKAVEKLEE EQRTLLARDE
260 270 280 290 300
DLTDKLSSYE PKVEECKAHL PTIENAVHSV LRVSQDLIGT ERKMEELTVQ
310 320 330 340 350
MFNMEDDMLK AVSEIMEMQN TLEGIQYDNS LLKMQNELVV LKGKVHDFMA
360 370
YSSAGEKGTL EEYNLENKGT DDY
Length:373
Mass (Da):42,361
Last modified:March 15, 2005 - v1
Checksum:iC6BA554B510E4E38
GO
Isoform 2 (identifier: Q5EAJ6-2) [UniParc]FASTAAdd to basket

Also known as: Ikip2

The sequence of this isoform differs from the canonical sequence as follows:
     97-373: LESTENTLQE...NLENKGTDDY → YQKCEALLEQ...MKDEITHISG

Show »
Length:345
Mass (Da):38,346
Checksum:iD6AABDBBB84834CD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 373277LESTE…GTDDY → YQKCEALLEQLKAFQIVAHL KLLQEEIHGMKTWSIGITEK QKILNNTLTSLSEDIIKVDQ GTASVAKDMGLKITSVKTDV RRISGLVTEVESLTDAVQAL ENKVKKVETATVESIGDLLS SSIDRTTALRKTASENSRRI DSVTKRLAELQGDFDEHTDR FLSLESERAKVLKAVSFAND LKPKVYNLKKDFSRLEPLVN DLTLRIGRLGSDLMQREKEI ASLKEKISNLTIVQAAIKDM KDEITHISG in isoform 2. 2 PublicationsVSP_034412Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN000112 mRNA. Translation: CAD62384.1.
BN000113 mRNA. Translation: CAD62385.1.
BC088210 mRNA. Translation: AAH88210.1.
RefSeqiNP_001009430.2. NM_001009430.2. [Q5EAJ6-1]
XP_006241312.1. XM_006241250.2. [Q5EAJ6-2]
UniGeneiRn.13471.

Genome annotation databases

EnsembliENSRNOT00000010914; ENSRNOP00000010913; ENSRNOG00000008247. [Q5EAJ6-1]
ENSRNOT00000010929; ENSRNOP00000010929; ENSRNOG00000008247. [Q5EAJ6-2]
GeneIDi314730.
KEGGirno:314730.
UCSCiRGD:1305457. rat. [Q5EAJ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN000112 mRNA. Translation: CAD62384.1.
BN000113 mRNA. Translation: CAD62385.1.
BC088210 mRNA. Translation: AAH88210.1.
RefSeqiNP_001009430.2. NM_001009430.2. [Q5EAJ6-1]
XP_006241312.1. XM_006241250.2. [Q5EAJ6-2]
UniGeneiRn.13471.

3D structure databases

ProteinModelPortaliQ5EAJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi260816. 1 interaction.
STRINGi10116.ENSRNOP00000010913.

Proteomic databases

PaxDbiQ5EAJ6.
PRIDEiQ5EAJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010914; ENSRNOP00000010913; ENSRNOG00000008247. [Q5EAJ6-1]
ENSRNOT00000010929; ENSRNOP00000010929; ENSRNOG00000008247. [Q5EAJ6-2]
GeneIDi314730.
KEGGirno:314730.
UCSCiRGD:1305457. rat. [Q5EAJ6-1]

Organism-specific databases

CTDi121457.
RGDi1305457. Ikbip.

Phylogenomic databases

eggNOGiENOG410IJN2. Eukaryota.
ENOG410YFQ8. LUCA.
GeneTreeiENSGT00500000045001.
HOGENOMiHOG000113024.
HOVERGENiHBG108000.
InParanoidiQ5EAJ6.
OMAiEECKTHL.
OrthoDBiEOG7673B1.
PhylomeDBiQ5EAJ6.
TreeFamiTF331715.

Miscellaneous databases

NextBioi668144.
PROiQ5EAJ6.

Gene expression databases

GenevisibleiQ5EAJ6. RN.

Family and domain databases

InterProiIPR024152. Inh_kappa-B_kinase-int.
[Graphical view]
PANTHERiPTHR21734. PTHR21734. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53."
    Hofer-Warbinek R., Schmid J.A., Mayer H., Winsauer G., Orel L., Mueller B., Wiesner C., Binder B.R., de Martin R.
    Cell Death Differ. 11:1317-1325(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.

Entry informationi

Entry nameiIKIP_RAT
AccessioniPrimary (citable) accession number: Q5EAJ6
Secondary accession number(s): Q5M859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 15, 2005
Last modified: November 11, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.