Reviewed, UniProtKB/Swiss-Prot Q5EAF2 (IP5PB_ARATH)

Names and origin

Protein names

Recommended name:
    Type I inositol-1,4,5-trisphosphate 5-phosphatase 11
      Short name=At5PTase11
    EC=3.1.3.56

Gene names

Ordered Locus Names:	At1g47510
ORF Names:	F16N3.22

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has phosphatase activity toward PtdIns(4,5)P2, and in vitro toward PtdIns(3,5)P2 and PtdIns(3,4,5)P3. Can not dephosphorylate PtdIns5P, Ins(1,4,5)P3 and Ins(1,3,4,5)P4. Ref.3
Catalytic activity	D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate. 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Tissue specificity	Expressed ubiquitously. Ref.3
Induction	Induced by abscisic acid (ABA), jasmonic acid (JA) and auxin. Ref.3
Sequence similarities	Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type I family.
Caution	It is uncertain whether Met-1 or Met-4 is the initiator.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphoinositide dephosphorylation Ref.3 Inferred from direct assay. Source: TAIR response to abscisic acid stimulus Ref.3 Inferred from expression pattern. Source: TAIR response to auxin stimulus Ref.3 Inferred from expression pattern. Source: TAIR response to jasmonic acid stimulus Ref.3 Inferred from expression pattern. Source: TAIR
Molecular function	inositol-polyphosphate 5-phosphatase activity Inferred from electronic annotation. Source: EC phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Ref.3 Inferred from direct assay. Source: TAIR phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Ref.3 Inferred from direct assay. Source: TAIR phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Ref.3 Inferred from direct assay. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Type I inositol-1,4,5-trisphosphate 5-phosphatase 11		PRO_0000209725
Regions
	Region	206 – 222	17	Catalytic 1 Potential
	Region	282 – 297	16	Catalytic 2 Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5EAF2-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 73F28B12173C772A	FASTA	334	37,580
	10 20 30 40 50 60 MPTMGNKNSM CGLKRFPNYK KSPIGSFAKN SSSHDGIKTI EAVNSCSFSR KADLCIRIIT 70 80 90 100 110 120 WNMNGNVSYE DLVELVGKER KFDLLVVGLQ EAPKANVDQL LQTASSPTHE LLGKAKLQSV 130 140 150 160 170 180 QLYLFGPKNS HTLVKELKAE RYSVGGCGGL IGRKKGAVAI RINYDDIKMV FISCHLSAHA 190 200 210 220 230 240 KKVDQRNTEL RHIANSLLPR DKRKRDLTVW LGDLNYRIQD VSNHPVRSLI QNHLQSVLVS 250 260 270 280 290 300 KDQLLQEAER GEIFKGYSEG TLGFKPTYKY NVGSSDYDTS HKIRVPAWTD RILFKIQDTD 310 320 330 NIQATLHSYD SIDQVYGSDH KPVKADLCLK WVNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Arabidopsis ORF clones." Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Molecular characterization of an Arabidopsis gene encoding a phospholipid-specific inositol polyphosphate 5-phosphatase." Ercetin M.E., Gillaspy G.E. Plant Physiol. 135:938-946(2002) [PubMed: 15181205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-334, FUNCTION, INDUCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC007519 Genomic DNA. Translation: AAD46036.1. Different initiation. BT020617 mRNA. Translation: AAW81725.1. BT021928 mRNA. Translation: AAX49377.1. AY627297 mRNA. Translation: AAT45895.1.
IPI	IPI00530331.
PIR	D96515.
RefSeq	NP_175182.2.
UniGene	At.49311
3D structure databases
SMR	Q5EAF2. Positions 42-330.
ModBase	Search...
Genome annotation databases
GeneID	841160.
GenomeReviews	Gene locus AT1G47510 in contig CT485782_GR.
KEGG	ath:AT1G47510.
NMPDR	fig|3702.1.peg.4211.
Organism-specific databases
TAIR	At1g47510.
Phylogenomic databases
eggNOG	KOG0565.
HOGENOM	HBG320125.
InParanoid	Q5EAF2.
OMA	GYCEGTL.
PhylomeDB	Q5EAF2.
Enzyme and pathway databases
BRENDA	3.1.3.56. 302.
Gene expression databases
Genevestigator	Q5EAF2.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. IPR000300. IPPc. [Graphical view]
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
SMART	SM00128. IPPc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IP5PB_ARATH

Accession

Primary (citable) accession number: Q5EAF2
Secondary accession number(s): Q9SX81

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	March 15, 2005
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)