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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Gene

ERGIC3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Gene namesi
Name:ERGIC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence analysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Topological domaini47 – 341295LumenalSequence analysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence analysisAdd
BLAST
Topological domaini363 – 38321CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Endoplasmic reticulum-Golgi intermediate compartment protein 3PRO_0000239387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PRIDEiQ5EAE0.

Interactioni

Subunit structurei

Interacts with ERGIC1/ERGIC32.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000210954.
HOVERGENiHBG105706.
InParanoidiQ5EAE0.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5EAE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL
60 70 80 90 100
TTEVHPELYV DKSRGDKLKI NINVLFPHMP CAYLSIDAMD VAGEQQLDVE
110 120 130 140 150
HNLFKKRLDK DGFPVSSEAE RHELGKVEVK VFDPDSLDPD RCESCYGAEM
160 170 180 190 200
EDIKCCNSCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ
210 220 230 240 250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIRHLS
260 270 280 290 300
FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF
310 320 330 340 350
SVTRHEKVAN GLMGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA
360 370 380
IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT
Length:383
Mass (Da):43,375
Last modified:March 15, 2005 - v1
Checksum:iE97E82112E8D835E
GO
Isoform 2 (identifier: Q5EAE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-231: VHD → GLR
     232-383: Missing.

Show »
Length:231
Mass (Da):26,401
Checksum:iC3AC4A97DA5A1CDF
GO
Isoform 3 (identifier: Q5EAE0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-283: INMTHYIRHL...MMFQYFVKVV → VRTRWKPWRV...TMNHGLTGAV
     284-383: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):32,184
Checksum:iCB030270717B8765
GO

Sequence cautioni

The sequence AAX46646.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei229 – 2313VHD → GLR in isoform 2. 1 PublicationVSP_019213
Alternative sequencei232 – 383152Missing in isoform 2. 1 PublicationVSP_019214Add
BLAST
Alternative sequencei240 – 28344INMTH…FVKVV → VRTRWKPWRVDGGGGLVAAF ILCRDILGWGSRYRTMNHGL TGAV in isoform 3. 1 PublicationVSP_019215Add
BLAST
Alternative sequencei284 – 383100Missing in isoform 3. 1 PublicationVSP_019216Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020628 mRNA. Translation: AAX08645.1.
BT020629 mRNA. Translation: AAX08646.1.
BT020688 mRNA. Translation: AAX08705.1.
BT021799 mRNA. Translation: AAX46646.1. Different initiation.
BT021881 mRNA. Translation: AAX46728.1.
BT026271 mRNA. Translation: ABG81427.1.
BC102326 mRNA. Translation: AAI02327.1.
RefSeqiNP_001029525.2. NM_001034353.2. [Q5EAE0-1]
UniGeneiBt.6352.

Genome annotation databases

GeneIDi509546.
KEGGibta:509546.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020628 mRNA. Translation: AAX08645.1.
BT020629 mRNA. Translation: AAX08646.1.
BT020688 mRNA. Translation: AAX08705.1.
BT021799 mRNA. Translation: AAX46646.1. Different initiation.
BT021881 mRNA. Translation: AAX46728.1.
BT026271 mRNA. Translation: ABG81427.1.
BC102326 mRNA. Translation: AAI02327.1.
RefSeqiNP_001029525.2. NM_001034353.2. [Q5EAE0-1]
UniGeneiBt.6352.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5EAE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi509546.
KEGGibta:509546.

Organism-specific databases

CTDi51614.

Phylogenomic databases

HOGENOMiHOG000210954.
HOVERGENiHBG105706.
InParanoidiQ5EAE0.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiERGI3_BOVIN
AccessioniPrimary (citable) accession number: Q5EAE0
Secondary accession number(s): Q0V8E8
, Q3T0M8, Q58CR6, Q58CZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.