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Q5EAD0

- BAIP2_BOVIN

UniProt

Q5EAD0 - BAIP2_BOVIN

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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2

Gene

BAIAP2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity).By similarity

GO - Molecular functioni

  1. proline-rich region binding Source: UniProtKB

GO - Biological processi

  1. actin crosslink formation Source: UniProtKB
  2. actin filament bundle assembly Source: UniProtKB
  3. filopodium assembly Source: InterPro
  4. regulation of actin cytoskeleton organization Source: UniProtKB
  5. regulation of cell shape Source: UniProtKB
  6. response to bacterium Source: UniProtKB
  7. signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2
Short name:
BAI-associated protein 2
Short name:
BAI1-associated protein 2
Gene namesi
Name:BAIAP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 19

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity. Cell projectionfilopodium By similarity. Cell projectionruffle By similarity. Cytoplasmcytoskeleton By similarity
Note: Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity).By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
  3. cytosol Source: UniProtKB
  4. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Brain-specific angiogenesis inhibitor 1-associated protein 2PRO_0000064814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei324 – 3241PhosphoserineBy similarity
Modified residuei326 – 3261PhosphoserineBy similarity
Modified residuei341 – 3411PhosphothreonineBy similarity
Modified residuei347 – 3471PhosphoserineBy similarity
Modified residuei367 – 3671PhosphoserineBy similarity
Modified residuei455 – 4551PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues by INSR in response to insulin treatment.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5EAD0.

Expressioni

Gene expression databases

ExpressionAtlasiQ5EAD0. baseline.

Interactioni

Subunit structurei

Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, DIAPH1, EPS8, SHANK1, SHANK2, SHANK3, TIAM1, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5EAD0.
SMRiQ5EAD0. Positions 1-248, 379-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 250250IMDPROSITE-ProRule annotationAdd
BLAST
Domaini375 – 43864SH3PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili132 – 15322Sequence AnalysisAdd
BLAST

Domaini

The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation (By similarity).By similarity
The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.By similarity

Sequence similaritiesi

Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG71665.
GeneTreeiENSGT00390000005995.
HOGENOMiHOG000038005.
HOVERGENiHBG054462.
InParanoidiQ5EAD0.
KOiK05627.
OrthoDBiEOG7N0C3W.

Family and domain databases

InterProiIPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR14206. PTHR14206. 1 hit.
PfamiPF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EAD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK
60 70 80 90 100
GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE
110 120 130 140 150
LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG
160 170 180 190 200
SKNPQKYSDK ELQYIDAIGN KQGELESYVS DGYKTALTEE RRRFCFLVEK
210 220 230 240 250
QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPNKIPDRA VQLMQQMGNS
260 270 280 290 300
NGSILPSGLS ASKSNLVISD PIPGAKPLPV PPELAPFVGR LSAQENAPVM
310 320 330 340 350
NGVSGPDSED YNPWADRKAT QPKSTSPPQS QSKLSDSYSN TLPVRKSVAP
360 370 380 390 400
KNSYATTENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG
410 420 430 440 450
DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDNDG GDRLHMSLQQ
460 470 480 490 500
GKSSSTGNLL DKEDLALPPP DYGTSSRAFP TQTAGAFKQR PYSVAVPAFS
510 520
QGLDDYGARA VSSADVEVAR F
Length:521
Mass (Da):57,566
Last modified:March 15, 2005 - v1
Checksum:i283D43FE6B9FD1D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020639 mRNA. Translation: AAX08656.1.
RefSeqiNP_001017937.1. NM_001017937.1.
XP_005221080.1. XM_005221023.1.
UniGeneiBt.17140.

Genome annotation databases

EnsembliENSBTAT00000025350; ENSBTAP00000025350; ENSBTAG00000019044.
GeneIDi507837.
KEGGibta:507837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020639 mRNA. Translation: AAX08656.1 .
RefSeqi NP_001017937.1. NM_001017937.1.
XP_005221080.1. XM_005221023.1.
UniGenei Bt.17140.

3D structure databases

ProteinModelPortali Q5EAD0.
SMRi Q5EAD0. Positions 1-248, 379-436.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5EAD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000025350 ; ENSBTAP00000025350 ; ENSBTAG00000019044 .
GeneIDi 507837.
KEGGi bta:507837.

Organism-specific databases

CTDi 10458.

Phylogenomic databases

eggNOGi NOG71665.
GeneTreei ENSGT00390000005995.
HOGENOMi HOG000038005.
HOVERGENi HBG054462.
InParanoidi Q5EAD0.
KOi K05627.
OrthoDBi EOG7N0C3W.

Enzyme and pathway databases

Reactomei REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

NextBioi 20868241.

Gene expression databases

ExpressionAtlasi Q5EAD0. baseline.

Family and domain databases

InterProi IPR027681. BAIAP2.
IPR013606. IRSp53/MIM_homology_IMD.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR14206. PTHR14206. 1 hit.
Pfami PF08397. IMD. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51338. IMD. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiBAIP2_BOVIN
AccessioniPrimary (citable) accession number: Q5EAD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3