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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2

Gene

BAIAP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-BTA-4420097 VEGFA-VEGFR2 Pathway
R-BTA-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2
Short name:
BAI-associated protein 2
Short name:
BAI1-associated protein 2
Gene namesi
Name:BAIAP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:26412 BAIAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648141 – 521Brain-specific angiogenesis inhibitor 1-associated protein 2Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei341PhosphothreonineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei361PhosphothreonineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei455PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues by INSR in response to insulin treatment.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5EAD0
PRIDEiQ5EAD0

Expressioni

Gene expression databases

BgeeiENSBTAG00000019044
ExpressionAtlasiQ5EAD0 baseline

Interactioni

Subunit structurei

Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, ADGRB1, DIAPH1, EPS8, SHANK1, SHANK2, SHANK3, TIAM1, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040235

Structurei

3D structure databases

ProteinModelPortaliQ5EAD0
SMRiQ5EAD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 250IMDPROSITE-ProRule annotationAdd BLAST250
Domaini375 – 438SH3PROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili132 – 153Sequence analysisAdd BLAST22

Domaini

The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation (By similarity).By similarity
The SH3 domain interacts with ATN1, ADGRB1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.By similarity

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410IKMM Eukaryota
ENOG41110CD LUCA
GeneTreeiENSGT00390000005995
HOGENOMiHOG000038005
HOVERGENiHBG054462
InParanoidiQ5EAD0
KOiK05627

Family and domain databases

CDDicd11915 SH3_Irsp53, 1 hit
Gene3Di1.20.1270.601 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR030128 IRSp53
IPR027681 IRSp53/IRTKS/Pinkbar
IPR035594 Irsp53_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14206 PTHR14206, 1 hit
PTHR14206:SF3 PTHR14206:SF3, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5EAD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTYAAK
60 70 80 90 100
GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE
110 120 130 140 150
LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG
160 170 180 190 200
SKNPQKYSDK ELQYIDAIGN KQGELESYVS DGYKTALTEE RRRFCFLVEK
210 220 230 240 250
QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPNKIPDRA VQLMQQMGNS
260 270 280 290 300
NGSILPSGLS ASKSNLVISD PIPGAKPLPV PPELAPFVGR LSAQENAPVM
310 320 330 340 350
NGVSGPDSED YNPWADRKAT QPKSTSPPQS QSKLSDSYSN TLPVRKSVAP
360 370 380 390 400
KNSYATTENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG
410 420 430 440 450
DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDNDG GDRLHMSLQQ
460 470 480 490 500
GKSSSTGNLL DKEDLALPPP DYGTSSRAFP TQTAGAFKQR PYSVAVPAFS
510 520
QGLDDYGARA VSSADVEVAR F
Length:521
Mass (Da):57,566
Last modified:March 15, 2005 - v1
Checksum:i283D43FE6B9FD1D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020639 mRNA Translation: AAX08656.1
RefSeqiNP_001017937.1, NM_001017937.1
XP_015314409.1, XM_015458923.1
UniGeneiBt.17140

Genome annotation databases

EnsembliENSBTAT00000025350; ENSBTAP00000025350; ENSBTAG00000019044
GeneIDi507837
KEGGibta:507837

Similar proteinsi

Entry informationi

Entry nameiBAIP2_BOVIN
AccessioniPrimary (citable) accession number: Q5EAD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome