Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 25 member 38

Gene

SLC25A38

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38UniRule annotation
Gene namesi
Name:SLC25A38UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5626Helical; Name=1UniRule annotationAdd
BLAST
Transmembranei89 – 11527Helical; Name=2UniRule annotationAdd
BLAST
Transmembranei127 – 15226Helical; Name=3UniRule annotationAdd
BLAST
Transmembranei180 – 20324Helical; Name=4UniRule annotationAdd
BLAST
Transmembranei221 – 24727Helical; Name=5UniRule annotationAdd
BLAST
Transmembranei276 – 29419Helical; Name=6UniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Solute carrier family 25 member 38PRO_0000291801Add
BLAST

Proteomic databases

PaxDbiQ5EAC0.
PRIDEiQ5EAC0.

Expressioni

Gene expression databases

ExpressionAtlasiQ5EAC0. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045521.

Structurei

3D structure databases

ProteinModelPortaliQ5EAC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 11490Solcar 1Add
BLAST
Repeati121 – 20585Solcar 2Add
BLAST
Repeati217 – 30185Solcar 3Add
BLAST

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation
Contains 3 Solcar repeats.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766. Eukaryota.
ENOG410XRMK. LUCA.
GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
HOVERGENiHBG054682.
InParanoidiQ5EAC0.
KOiK15118.
OrthoDBiEOG7BGHMD.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EAC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQKSRPALL QHQDVGDRVE TLMLQPVIKA FLCGSISGTC STLLFQPLDL
60 70 80 90 100
LKTRLQTLQP SAHGSRRVGM LALLLNVVRT ESPLGLWKGM SPSIVRCVPG
110 120 130 140 150
VGIYFGTLYS LKQYFLRGHP PTALESIILG AGSRSVAGVC MSPITVIKTR
160 170 180 190 200
YESGRYGYES VYAALRSICH SEGFRGLFSG LTATLLRDAP FSGIYLMFYS
210 220 230 240 250
QTKNVVLHRT DQLDAVLVPV VNFSCGIFAG ILASLVTQPA DVIKTHMQLF
260 270 280 290 300
PMKFRWIGQS VTLIFKDYGL RGFFQGSVPR ALRRTLMAAM AWTVYEEMMA

KMGLKS
Length:306
Mass (Da):33,798
Last modified:July 7, 2009 - v2
Checksum:i604E4B6090B5B1EA
GO

Sequence cautioni

The sequence AAX46648.1 differs from that shown. Reason: Frameshift at position 275. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631H → R in AAX08897 (PubMed:16305752).Curated
Sequence conflicti65 – 662Missing in AAX08897 (PubMed:16305752).Curated
Sequence conflicti144 – 1452IT → SA in AAX08830 (PubMed:16305752).Curated
Sequence conflicti159 – 1591E → K in AAX08669 (PubMed:16305752).Curated
Sequence conflicti220 – 2201V → L in AAX46648 (PubMed:16305752).Curated
Sequence conflicti220 – 2201V → L in AAX08669 (PubMed:16305752).Curated
Sequence conflicti220 – 2201V → L in AAX08666 (PubMed:16305752).Curated
Sequence conflicti220 – 2201V → L in ABG66996 (PubMed:16305752).Curated
Sequence conflicti220 – 2201V → L in AAX08897 (PubMed:16305752).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020649 mRNA. Translation: AAX08666.1.
BT020652 mRNA. Translation: AAX08669.1.
BT020813 mRNA. Translation: AAX08830.1.
BT020880 mRNA. Translation: AAX08897.1.
BT021801 mRNA. Translation: AAX46648.1. Frameshift.
BT026157 mRNA. Translation: ABG66996.1.
BC148053 mRNA. Translation: AAI48054.1.
RefSeqiNP_001014905.2. NM_001014905.2.
UniGeneiBt.6425.

Genome annotation databases

EnsembliENSBTAT00000020606; ENSBTAP00000020606; ENSBTAG00000022721.
GeneIDi512325.
KEGGibta:512325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020649 mRNA. Translation: AAX08666.1.
BT020652 mRNA. Translation: AAX08669.1.
BT020813 mRNA. Translation: AAX08830.1.
BT020880 mRNA. Translation: AAX08897.1.
BT021801 mRNA. Translation: AAX46648.1. Frameshift.
BT026157 mRNA. Translation: ABG66996.1.
BC148053 mRNA. Translation: AAI48054.1.
RefSeqiNP_001014905.2. NM_001014905.2.
UniGeneiBt.6425.

3D structure databases

ProteinModelPortaliQ5EAC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045521.

Proteomic databases

PaxDbiQ5EAC0.
PRIDEiQ5EAC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020606; ENSBTAP00000020606; ENSBTAG00000022721.
GeneIDi512325.
KEGGibta:512325.

Organism-specific databases

CTDi54977.

Phylogenomic databases

eggNOGiKOG0766. Eukaryota.
ENOG410XRMK. LUCA.
GeneTreeiENSGT00550000075117.
HOGENOMiHOG000006978.
HOVERGENiHBG054682.
InParanoidiQ5EAC0.
KOiK15118.
OrthoDBiEOG7BGHMD.

Miscellaneous databases

NextBioi20870341.

Gene expression databases

ExpressionAtlasiQ5EAC0. baseline.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiS2538_BOVIN
AccessioniPrimary (citable) accession number: Q5EAC0
Secondary accession number(s): A6QLQ9
, Q58CZ6, Q5E9P0, Q5E9V7, Q5EAB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 7, 2009
Last modified: February 17, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.