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Q5EAC0 (S2538_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 25 member 38
Gene names
Name:SLC25A38
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane By similarity. HAMAP-Rule MF_03064

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_03064.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]

Contains 3 Solcar repeats.

Sequence caution

The sequence AAX46648.1 differs from that shown. Reason: Frameshift at position 275.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Solute carrier family 25 member 38 HAMAP-Rule MF_03064
PRO_0000291801

Regions

Transmembrane31 – 5626Helical; Name=1; Potential
Transmembrane89 – 11527Helical; Name=2; Potential
Transmembrane127 – 15226Helical; Name=3; Potential
Transmembrane180 – 20324Helical; Name=4; Potential
Transmembrane221 – 24727Helical; Name=5; Potential
Transmembrane276 – 29419Helical; Name=6; Potential
Repeat25 – 11490Solcar 1 HAMAP-Rule MF_03064
Repeat121 – 20585Solcar 2 HAMAP-Rule MF_03064
Repeat217 – 30185Solcar 3 HAMAP-Rule MF_03064

Experimental info

Sequence conflict631H → R in AAX08897. Ref.1
Sequence conflict65 – 662Missing in AAX08897. Ref.1
Sequence conflict144 – 1452IT → SA in AAX08830. Ref.1
Sequence conflict1591E → K in AAX08669. Ref.1
Sequence conflict2201V → L in AAX46648. Ref.1
Sequence conflict2201V → L in AAX08669. Ref.1
Sequence conflict2201V → L in AAX08666. Ref.1
Sequence conflict2201V → L in ABG66996. Ref.1
Sequence conflict2201V → L in AAX08897. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q5EAC0 [UniParc].

Last modified July 7, 2009. Version 2.
Checksum: 604E4B6090B5B1EA

FASTA30633,798
        10         20         30         40         50         60 
MIQKSRPALL QHQDVGDRVE TLMLQPVIKA FLCGSISGTC STLLFQPLDL LKTRLQTLQP 

        70         80         90        100        110        120 
SAHGSRRVGM LALLLNVVRT ESPLGLWKGM SPSIVRCVPG VGIYFGTLYS LKQYFLRGHP 

       130        140        150        160        170        180 
PTALESIILG AGSRSVAGVC MSPITVIKTR YESGRYGYES VYAALRSICH SEGFRGLFSG 

       190        200        210        220        230        240 
LTATLLRDAP FSGIYLMFYS QTKNVVLHRT DQLDAVLVPV VNFSCGIFAG ILASLVTQPA 

       250        260        270        280        290        300 
DVIKTHMQLF PMKFRWIGQS VTLIFKDYGL RGFFQGSVPR ALRRTLMAAM AWTVYEEMMA 


KMGLKS 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT020649 mRNA. Translation: AAX08666.1.
BT020652 mRNA. Translation: AAX08669.1.
BT020813 mRNA. Translation: AAX08830.1.
BT020880 mRNA. Translation: AAX08897.1.
BT021801 mRNA. Translation: AAX46648.1. Frameshift.
BT026157 mRNA. Translation: ABG66996.1.
BC148053 mRNA. Translation: AAI48054.1.
RefSeqNP_001014905.2. NM_001014905.2.
UniGeneBt.6425.

3D structure databases

ProteinModelPortalQ5EAC0.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5EAC0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000020606; ENSBTAP00000020606; ENSBTAG00000022721.
GeneID512325.
KEGGbta:512325.

Organism-specific databases

CTD54977.

Phylogenomic databases

eggNOGNOG268441.
GeneTreeENSGT00550000075117.
HOGENOMHOG000006978.
HOVERGENHBG054682.
KOK15118.
OrthoDBEOG7BGHMD.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
HAMAPMF_03064. SLC25A38.
InterProIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870341.

Entry information

Entry nameS2538_BOVIN
AccessionPrimary (citable) accession number: Q5EAC0
Secondary accession number(s): A6QLQ9 expand/collapse secondary AC list , Q58CZ6, Q5E9P0, Q5E9V7, Q5EAB7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 7, 2009
Last modified: April 16, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families