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Protein

Chitinase domain-containing protein 1

Gene

CHID1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-BTA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase domain-containing protein 1
Gene namesi
Name:CHID1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Organism-specific databases

VGNCiVGNC:27294 CHID1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000028060720 – 393Chitinase domain-containing protein 1Add BLAST374

Proteomic databases

PRIDEiQ5EAB4

Expressioni

Gene expression databases

BgeeiENSBTAG00000009899
ExpressionAtlasiQ5EAB4 baseline and differential

Interactioni

Subunit structurei

Interacts with STAB1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5EAB4
SMRiQ5EAB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000012069
HOGENOMiHOG000006155
HOVERGENiHBG055278
InParanoidiQ5EAB4
KOiK17525

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EAB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLLGTLWL TLACSSVHAT LSKSDAKKAA SKTLQEKTQV SGKPAQERGL
60 70 80 90 100
VVTDLRAEDV VLEHRSYCSA KAHRKHFAGD VLGYITPWNR HGYDVAKIFG
110 120 130 140 150
GKFTHVAPVW LQLRRHGREM FEVTGLDDVD QGWLRAVRKQ AKGLRIVPRL
160 170 180 190 200
RFEDWTYEDF DSVLDNEDEI EELSRTVVQV AKSQHFDGLV VEVWNQLLVQ
210 220 230 240 250
KHAGLIHLLT HMAEALHQAR LLVFLVIPPA VAPGTNKLGM FTNTEFEQLA
260 270 280 290 300
PVLDGFSLMT YDYSTAQPAG PNAPLPWVRA CVQVLDPKSK WRSKILLGLN
310 320 330 340 350
FYGMDYSASK DAREPIIGAR YIQTLKDHRP QVVWDSQAAE HFFEYKKSRG
360 370 380 390
GRHVVFYPTL KSLQERLELA QELGVGLSIW ELGQGLDYFY DLL
Length:393
Mass (Da):44,562
Last modified:March 15, 2005 - v1
Checksum:iD3AE54A6660B64AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190V → M in AAI18450 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020630 mRNA Translation: AAX08647.1
BT020655 mRNA Translation: AAX08672.1
BT020789 mRNA Translation: AAX08806.1
BT020873 mRNA Translation: AAX08890.1
BT021168 mRNA Translation: AAX31350.1
BT021170 mRNA Translation: AAX31352.1
BT021178 mRNA Translation: AAX31360.1
BC118449 mRNA Translation: AAI18450.1
RefSeqiNP_001015515.1, NM_001015515.1
UniGeneiBt.5131

Genome annotation databases

EnsembliENSBTAT00000013065; ENSBTAP00000013065; ENSBTAG00000009899
GeneIDi504781
KEGGibta:504781

Similar proteinsi

Entry informationi

Entry nameiCHID1_BOVIN
AccessioniPrimary (citable) accession number: Q5EAB4
Secondary accession number(s): Q17QB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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