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Protein

Chitinase domain-containing protein 1

Gene

CHID1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase domain-containing protein 1
Gene namesi
Name:CHID1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 393374Chitinase domain-containing protein 1PRO_0000280607Add
BLAST

Proteomic databases

PRIDEiQ5EAB4.

Expressioni

Gene expression databases

ExpressionAtlasiQ5EAB4. baseline and differential.

Interactioni

Subunit structurei

Interacts with STAB1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5EAB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000012069.
HOGENOMiHOG000006155.
HOVERGENiHBG055278.
InParanoidiQ5EAB4.
KOiK17525.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR011583. Chitinase_II.
IPR001223. Glyco_hydro18_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EAB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLLGTLWL TLACSSVHAT LSKSDAKKAA SKTLQEKTQV SGKPAQERGL
60 70 80 90 100
VVTDLRAEDV VLEHRSYCSA KAHRKHFAGD VLGYITPWNR HGYDVAKIFG
110 120 130 140 150
GKFTHVAPVW LQLRRHGREM FEVTGLDDVD QGWLRAVRKQ AKGLRIVPRL
160 170 180 190 200
RFEDWTYEDF DSVLDNEDEI EELSRTVVQV AKSQHFDGLV VEVWNQLLVQ
210 220 230 240 250
KHAGLIHLLT HMAEALHQAR LLVFLVIPPA VAPGTNKLGM FTNTEFEQLA
260 270 280 290 300
PVLDGFSLMT YDYSTAQPAG PNAPLPWVRA CVQVLDPKSK WRSKILLGLN
310 320 330 340 350
FYGMDYSASK DAREPIIGAR YIQTLKDHRP QVVWDSQAAE HFFEYKKSRG
360 370 380 390
GRHVVFYPTL KSLQERLELA QELGVGLSIW ELGQGLDYFY DLL
Length:393
Mass (Da):44,562
Last modified:March 15, 2005 - v1
Checksum:iD3AE54A6660B64AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901V → M in AAI18450 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020630 mRNA. Translation: AAX08647.1.
BT020655 mRNA. Translation: AAX08672.1.
BT020789 mRNA. Translation: AAX08806.1.
BT020873 mRNA. Translation: AAX08890.1.
BT021168 mRNA. Translation: AAX31350.1.
BT021170 mRNA. Translation: AAX31352.1.
BT021178 mRNA. Translation: AAX31360.1.
BC118449 mRNA. Translation: AAI18450.1.
RefSeqiNP_001015515.1. NM_001015515.1.
UniGeneiBt.5131.

Genome annotation databases

EnsembliENSBTAT00000013065; ENSBTAP00000013065; ENSBTAG00000009899.
GeneIDi504781.
KEGGibta:504781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020630 mRNA. Translation: AAX08647.1.
BT020655 mRNA. Translation: AAX08672.1.
BT020789 mRNA. Translation: AAX08806.1.
BT020873 mRNA. Translation: AAX08890.1.
BT021168 mRNA. Translation: AAX31350.1.
BT021170 mRNA. Translation: AAX31352.1.
BT021178 mRNA. Translation: AAX31360.1.
BC118449 mRNA. Translation: AAI18450.1.
RefSeqiNP_001015515.1. NM_001015515.1.
UniGeneiBt.5131.

3D structure databases

ProteinModelPortaliQ5EAB4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Proteomic databases

PRIDEiQ5EAB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013065; ENSBTAP00000013065; ENSBTAG00000009899.
GeneIDi504781.
KEGGibta:504781.

Organism-specific databases

CTDi66005.

Phylogenomic databases

GeneTreeiENSGT00390000012069.
HOGENOMiHOG000006155.
HOVERGENiHBG055278.
InParanoidiQ5EAB4.
KOiK17525.

Gene expression databases

ExpressionAtlasiQ5EAB4. baseline and differential.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR011583. Chitinase_II.
IPR001223. Glyco_hydro18_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.

Entry informationi

Entry nameiCHID1_BOVIN
AccessioniPrimary (citable) accession number: Q5EAB4
Secondary accession number(s): Q17QB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.