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Protein

Microfibrillar-associated protein 1

Gene

MFAP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the elastin-associated microfibrils.By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibrillar-associated protein 1
Gene namesi
Name:MFAP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 439438Microfibrillar-associated protein 1PRO_0000269915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei52 – 521PhosphoserineBy similarity
Modified residuei53 – 531PhosphoserineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei116 – 1161PhosphoserineBy similarity
Modified residuei118 – 1181PhosphoserineBy similarity
Modified residuei132 – 1321PhosphoserineBy similarity
Modified residuei133 – 1331PhosphoserineBy similarity
Cross-linki249 – 249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei267 – 2671PhosphothreonineBy similarity
Modified residuei361 – 3611PhosphoserineBy similarity
Modified residuei432 – 4321PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5EA98.
PeptideAtlasiQ5EA98.
PRIDEiQ5EA98.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017213.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022877.

Structurei

3D structure databases

ProteinModelPortaliQ5EA98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi134 – 1396Poly-Glu

Sequence similaritiesi

Belongs to the MFAP1 family.Curated

Phylogenomic databases

eggNOGiKOG1425. Eukaryota.
ENOG410Y1JB. LUCA.
GeneTreeiENSGT00690000102225.
HOGENOMiHOG000231845.
HOVERGENiHBG052462.
InParanoidiQ5EA98.
KOiK13110.
OMAiFDRPTVK.
OrthoDBiEOG091G0DXV.
TreeFamiTF314398.

Family and domain databases

InterProiIPR033194. MFAP1.
IPR009730. MFAP1_C.
[Graphical view]
PANTHERiPTHR15327:SF0. PTHR15327:SF0. 1 hit.
PfamiPF06991. MFAP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EA98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPSSLMKQ PPIQSTAGAV PVRNEKGEIS MEKVKVKRYV SGKRPDYAPM
60 70 80 90 100
ESSDEEDEEF QFIKKAKEQE AEPEEQEEDS SSDPRLRRLQ NRISEDVEER
110 120 130 140 150
LARHRKIVEP EVVGESDSEV EGDPWRMERE DSSEEEEEEI DEEEIERRRG
160 170 180 190 200
MMRQRAQERK NEELEVMEVE DEGRSGEESE SESEYEEYTD SEDEMEPRLK
210 220 230 240 250
PVFIRKKDRV TVQEREAEAL KQKELEQEAK HMAEERRKYT LKIVEEETKK
260 270 280 290 300
ELEENKRSLA ALDALNTDDE NDEEEYEAWK VRELKRIKRD REDREALEKE
310 320 330 340 350
KAEIERMRNL TEEERRAELR ANGKVITNKA VKGKYKFLQK YYHRGAFFMD
360 370 380 390 400
EDEEVYKRDF SAPTLEDHFN KTILPKVMQV KNFGRSGRTK YTHLVDQDTT
410 420 430
SFDSAWGQES AQNTKFFKQK AAGVRDVFER PSAKKRKTT
Length:439
Mass (Da):51,977
Last modified:March 15, 2005 - v1
Checksum:iE4EF82187A2E56E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020671 mRNA. Translation: AAX08688.1.
RefSeqiNP_001029569.1. NM_001034397.1.
UniGeneiBt.52288.

Genome annotation databases

EnsembliENSBTAT00000022877; ENSBTAP00000022877; ENSBTAG00000017213.
GeneIDi510905.
KEGGibta:510905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020671 mRNA. Translation: AAX08688.1.
RefSeqiNP_001029569.1. NM_001034397.1.
UniGeneiBt.52288.

3D structure databases

ProteinModelPortaliQ5EA98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022877.

Proteomic databases

PaxDbiQ5EA98.
PeptideAtlasiQ5EA98.
PRIDEiQ5EA98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022877; ENSBTAP00000022877; ENSBTAG00000017213.
GeneIDi510905.
KEGGibta:510905.

Organism-specific databases

CTDi4236.

Phylogenomic databases

eggNOGiKOG1425. Eukaryota.
ENOG410Y1JB. LUCA.
GeneTreeiENSGT00690000102225.
HOGENOMiHOG000231845.
HOVERGENiHBG052462.
InParanoidiQ5EA98.
KOiK13110.
OMAiFDRPTVK.
OrthoDBiEOG091G0DXV.
TreeFamiTF314398.

Enzyme and pathway databases

ReactomeiR-BTA-2129379. Molecules associated with elastic fibres.

Gene expression databases

BgeeiENSBTAG00000017213.

Family and domain databases

InterProiIPR033194. MFAP1.
IPR009730. MFAP1_C.
[Graphical view]
PANTHERiPTHR15327:SF0. PTHR15327:SF0. 1 hit.
PfamiPF06991. MFAP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFAP1_BOVIN
AccessioniPrimary (citable) accession number: Q5EA98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.