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Q5EA88

- GPDA_BOVIN

UniProt

Q5EA88 - GPDA_BOVIN

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Protein
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Gene
GPD1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411NAD By similarity
Binding sitei97 – 971NAD By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei153 – 1531NAD; via amide nitrogen By similarity
Active sitei204 – 2041Proton acceptor Reviewed prediction
Binding sitei269 – 2691NAD By similarity
Binding sitei296 – 2961NAD; via amide nitrogen By similarity
Binding sitei298 – 2981NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  3. glycerol-3-phosphate dehydrogenase activity Source: AgBase

GO - Biological processi

  1. carbohydrate metabolic process Source: AgBase
  2. cellular response to cAMP Source: Ensembl
  3. cellular response to tumor necrosis factor Source: Ensembl
  4. gluconeogenesis Source: AgBase
  5. glycerol-3-phosphate catabolic process Source: InterPro
  6. glycerol-3-phosphate metabolic process Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_209849. Triglyceride Biosynthesis.
REACT_211382. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)
Short name:
GPD-C
Short name:
GPDH-C
Gene namesi
Name:GPD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: AgBase
  2. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  3. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
PRO_0000262289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891N6-succinyllysine By similarity

Proteomic databases

PaxDbiQ5EA88.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5EA88.
SMRiQ5EA88. Positions 4-349.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2702Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ5EA88.
KOiK00006.
OMAiPVGEFIH.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA88-1 [UniParc]FASTAAdd to Basket

« Hide

MTGKKVCIVG SGNWGSAIAK IVGGNAAQLA HFDPRVTMWV FEEDIGGRKL    50
TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAADADILI FVVPHQFIGK 100
ICDQLKGHLK ADTIGVSLIK GVDEGPKGLK LISEVIGERL GIPMSVLMGA 150
NIANEVADEK FCETTIGSKN QAHGQLLKEL MQTPNFRITV VQEVDTVEIC 200
GALKNIVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGSVSSA 250
TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE MLNGQKLQGP 300
QTARELHSIL QHKGMVDKFP LFTAVYKVCY ENQPVGEFIH CLQNHPEHV 349
Length:349
Mass (Da):37,648
Last modified:January 23, 2007 - v3
Checksum:i59E7DFADE8FC1A80
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221V → L in AAX08698. 1 Publication
Sequence conflicti313 – 3131K → R in AAX08698. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020681 mRNA. Translation: AAX08698.1.
BC105513 mRNA. Translation: AAI05514.1.
RefSeqiNP_001030431.1. NM_001035354.1.
UniGeneiBt.5002.

Genome annotation databases

EnsembliENSBTAT00000021683; ENSBTAP00000021683; ENSBTAG00000016296.
GeneIDi525042.
KEGGibta:525042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020681 mRNA. Translation: AAX08698.1 .
BC105513 mRNA. Translation: AAI05514.1 .
RefSeqi NP_001030431.1. NM_001035354.1.
UniGenei Bt.5002.

3D structure databases

ProteinModelPortali Q5EA88.
SMRi Q5EA88. Positions 4-349.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q5EA88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021683 ; ENSBTAP00000021683 ; ENSBTAG00000016296 .
GeneIDi 525042.
KEGGi bta:525042.

Organism-specific databases

CTDi 2819.

Phylogenomic databases

eggNOGi COG0240.
GeneTreei ENSGT00390000003114.
HOGENOMi HOG000246855.
HOVERGENi HBG003669.
InParanoidi Q5EA88.
KOi K00006.
OMAi PVGEFIH.
OrthoDBi EOG7ZKSBS.
TreeFami TF300836.

Enzyme and pathway databases

Reactomei REACT_209849. Triglyceride Biosynthesis.
REACT_211382. Synthesis of PA.

Miscellaneous databases

NextBioi 20874083.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-349.
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiGPDA_BOVIN
AccessioniPrimary (citable) accession number: Q5EA88
Secondary accession number(s): Q2HJE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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