UniProtKB - Q5EA88 (GPDA_BOVIN)
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Protein
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
Gene
GPD1
Organism
Bos taurus (Bovine)
Status
Functioni
Catalytic activityi
sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 41 | NADBy similarity | 1 | |
Binding sitei | 97 | NADBy similarity | 1 | |
Binding sitei | 120 | SubstrateBy similarity | 1 | |
Binding sitei | 153 | NAD; via amide nitrogenBy similarity | 1 | |
Active sitei | 204 | Proton acceptorSequence analysis | 1 | |
Binding sitei | 269 | NADBy similarity | 1 | |
Binding sitei | 296 | NAD; via amide nitrogenBy similarity | 1 | |
Binding sitei | 298 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 15 | NADBy similarity | 6 |
GO - Molecular functioni
- glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
- glycerol-3-phosphate dehydrogenase activity Source: AgBase
- NAD binding Source: InterPro
- protein homodimerization activity Source: InterPro
GO - Biological processi
- carbohydrate metabolic process Source: AgBase
- cellular response to cAMP Source: Ensembl
- cellular response to tumor necrosis factor Source: Ensembl
- gluconeogenesis Source: AgBase
- glycerol-3-phosphate catabolic process Source: InterPro
- glycerol-3-phosphate metabolic process Source: AgBase
- glycerophosphate shuttle Source: Ensembl
- positive regulation of glycolytic process Source: Ensembl
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-BTA-1483166. Synthesis of PA. |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)Short name: GPD-C Short name: GPDH-C |
Gene namesi | Name:GPD1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:29529. GPD1. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000262289 | 1 – 349 | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicAdd BLAST | 349 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 289 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 326 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q5EA88. |
PeptideAtlasi | Q5EA88. |
PRIDEi | Q5EA88. |
Interactioni
Subunit structurei
Homodimer.By similarity
GO - Molecular functioni
- protein homodimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000021683. |
Structurei
3D structure databases
ProteinModelPortali | Q5EA88. |
SMRi | Q5EA88. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 269 – 270 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG2711. Eukaryota. COG0240. LUCA. |
GeneTreei | ENSGT00390000003114. |
HOGENOMi | HOG000246855. |
HOVERGENi | HBG003669. |
InParanoidi | Q5EA88. |
KOi | K00006. |
OMAi | WLCKGFE. |
OrthoDBi | EOG091G0DO6. |
TreeFami | TF300836. |
Family and domain databases
Gene3Di | 1.10.1040.10. 1 hit. |
InterProi | View protein in InterPro IPR008927. 6-PGluconate_DH-like_C_sf. IPR013328. 6PGD_dom2. IPR006168. G3P_DH_NAD-dep. IPR006109. G3P_DH_NAD-dep_C. IPR017751. G3P_DH_NAD-dep_euk. IPR011128. G3P_DH_NAD-dep_N. IPR036291. NAD(P)-bd_dom_sf. |
Pfami | View protein in Pfam PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. |
PIRSFi | PIRSF000114. Glycerol-3-P_dh. 1 hit. |
PRINTSi | PR00077. GPDHDRGNASE. |
SUPFAMi | SSF48179. SSF48179. 1 hit. SSF51735. SSF51735. 1 hit. |
TIGRFAMsi | TIGR03376. glycerol3P_DH. 1 hit. |
PROSITEi | View protein in PROSITE PS00957. NAD_G3PDH. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q5EA88-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTGKKVCIVG SGNWGSAIAK IVGGNAAQLA HFDPRVTMWV FEEDIGGRKL
60 70 80 90 100
TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAADADILI FVVPHQFIGK
110 120 130 140 150
ICDQLKGHLK ADTIGVSLIK GVDEGPKGLK LISEVIGERL GIPMSVLMGA
160 170 180 190 200
NIANEVADEK FCETTIGSKN QAHGQLLKEL MQTPNFRITV VQEVDTVEIC
210 220 230 240 250
GALKNIVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGSVSSA
260 270 280 290 300
TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE MLNGQKLQGP
310 320 330 340
QTARELHSIL QHKGMVDKFP LFTAVYKVCY ENQPVGEFIH CLQNHPEHV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 122 | V → L in AAX08698 (PubMed:16305752).Curated | 1 | |
Sequence conflicti | 313 | K → R in AAX08698 (PubMed:16305752).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT020681 mRNA. Translation: AAX08698.1. BC105513 mRNA. Translation: AAI05514.1. |
RefSeqi | NP_001030431.1. NM_001035354.1. |
UniGenei | Bt.5002. |
Genome annotation databases
Ensembli | ENSBTAT00000021683; ENSBTAP00000021683; ENSBTAG00000016296. |
GeneIDi | 525042. |
KEGGi | bta:525042. |
Similar proteinsi
Entry informationi
Entry namei | GPDA_BOVIN | |
Accessioni | Q5EA88Primary (citable) accession number: Q5EA88 Secondary accession number(s): Q2HJE6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | March 28, 2018 | |
This is version 98 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |