Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5EA88

- GPDA_BOVIN

UniProt

Q5EA88 - GPDA_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Gene

GPD1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411NADBy similarity
Binding sitei97 – 971NADBy similarity
Binding sitei120 – 1201SubstrateBy similarity
Binding sitei153 – 1531NAD; via amide nitrogenBy similarity
Active sitei204 – 2041Proton acceptorSequence Analysis
Binding sitei269 – 2691NADBy similarity
Binding sitei296 – 2961NAD; via amide nitrogenBy similarity
Binding sitei298 – 2981NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. glycerol-3-phosphate dehydrogenase activity Source: AgBase
  3. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: AgBase
  2. cellular response to cAMP Source: Ensembl
  3. cellular response to tumor necrosis factor Source: Ensembl
  4. gluconeogenesis Source: AgBase
  5. glycerol-3-phosphate catabolic process Source: InterPro
  6. glycerol-3-phosphate metabolic process Source: AgBase
  7. glycerophosphate shuttle Source: Ensembl
  8. positive regulation of glycolytic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_209849. Triglyceride Biosynthesis.
REACT_211382. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (EC:1.1.1.8)
Short name:
GPD-C
Short name:
GPDH-C
Gene namesi
Name:GPD1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: AgBase
  2. extracellular vesicular exosome Source: Ensembl
  3. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  4. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmicPRO_0000262289Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei289 – 2891N6-succinyllysineBy similarity

Proteomic databases

PaxDbiQ5EA88.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5EA88.
SMRiQ5EA88. Positions 4-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2702Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ5EA88.
KOiK00006.
OMAiPVGEFIH.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGKKVCIVG SGNWGSAIAK IVGGNAAQLA HFDPRVTMWV FEEDIGGRKL
60 70 80 90 100
TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAADADILI FVVPHQFIGK
110 120 130 140 150
ICDQLKGHLK ADTIGVSLIK GVDEGPKGLK LISEVIGERL GIPMSVLMGA
160 170 180 190 200
NIANEVADEK FCETTIGSKN QAHGQLLKEL MQTPNFRITV VQEVDTVEIC
210 220 230 240 250
GALKNIVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGSVSSA
260 270 280 290 300
TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE MLNGQKLQGP
310 320 330 340
QTARELHSIL QHKGMVDKFP LFTAVYKVCY ENQPVGEFIH CLQNHPEHV
Length:349
Mass (Da):37,648
Last modified:January 23, 2007 - v3
Checksum:i59E7DFADE8FC1A80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221V → L in AAX08698. (PubMed:16305752)Curated
Sequence conflicti313 – 3131K → R in AAX08698. (PubMed:16305752)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020681 mRNA. Translation: AAX08698.1.
BC105513 mRNA. Translation: AAI05514.1.
RefSeqiNP_001030431.1. NM_001035354.1.
UniGeneiBt.5002.

Genome annotation databases

EnsembliENSBTAT00000021683; ENSBTAP00000021683; ENSBTAG00000016296.
GeneIDi525042.
KEGGibta:525042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020681 mRNA. Translation: AAX08698.1 .
BC105513 mRNA. Translation: AAI05514.1 .
RefSeqi NP_001030431.1. NM_001035354.1.
UniGenei Bt.5002.

3D structure databases

ProteinModelPortali Q5EA88.
SMRi Q5EA88. Positions 4-349.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q5EA88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021683 ; ENSBTAP00000021683 ; ENSBTAG00000016296 .
GeneIDi 525042.
KEGGi bta:525042.

Organism-specific databases

CTDi 2819.

Phylogenomic databases

eggNOGi COG0240.
GeneTreei ENSGT00390000003114.
HOGENOMi HOG000246855.
HOVERGENi HBG003669.
InParanoidi Q5EA88.
KOi K00006.
OMAi PVGEFIH.
OrthoDBi EOG7ZKSBS.
TreeFami TF300836.

Enzyme and pathway databases

Reactomei REACT_209849. Triglyceride Biosynthesis.
REACT_211382. Synthesis of PA.

Miscellaneous databases

NextBioi 20874083.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-349.
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiGPDA_BOVIN
AccessioniPrimary (citable) accession number: Q5EA88
Secondary accession number(s): Q2HJE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3