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Protein

Docking protein 1

Gene

DOK1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 1
Alternative name(s):
Downstream of tyrosine kinase 1
Gene namesi
Name:DOK1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Docking protein 1PRO_0000187267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei269 – 2691PhosphoserineBy similarity
Modified residuei291 – 2911PhosphoserineBy similarity
Modified residuei296 – 2961PhosphotyrosineBy similarity
Modified residuei337 – 3371PhosphotyrosineBy similarity
Modified residuei362 – 3621PhosphotyrosineBy similarity
Modified residuei377 – 3771PhosphotyrosineBy similarity
Modified residuei398 – 3981PhosphotyrosineBy similarity
Modified residuei409 – 4091PhosphotyrosineBy similarity
Modified residuei416 – 4161PhosphoserineBy similarity
Modified residuei451 – 4511PhosphotyrosineBy similarity

Post-translational modificationi

Constitutively tyrosine-phosphorylated (By similarity). Phosphorylated by TEC. Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway (By similarity). Phosphorylated on tyrosine residues by SRMS (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5EA84.
PRIDEiQ5EA84.

Interactioni

Subunit structurei

Interacts with RasGAP, INPP5D/SHIP1 and ABL1. Interacts directly with phosphorylated ITGB3 (By similarity). Interacts with SRMS (via the SH2 and SH3 domains) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024727.

Structurei

3D structure databases

ProteinModelPortaliQ5EA84.
SMRiQ5EA84. Positions 153-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 119116PHAdd
BLAST
Domaini151 – 259109IRS-type PTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DOK family. Type A subfamily.Curated
Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
HOGENOMiHOG000112245.
HOVERGENiHBG018962.
InParanoidiQ5EA84.
KOiK14752.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGAVMEGPL FLQSQRFGTK RWRKTWAVLY PASPHGVARL EFFDHKGSSS
60 70 80 90 100
GGGRGSSRRL DCKVIRLAEC VSVAPVAVES PPEPGAASFR LDTAQRSHLL
110 120 130 140 150
AADAPSSAAW VQTLCQNAFP KGSWALAPAE NPPKLSALEM LENSLYSPSW
160 170 180 190 200
EGSQFWVTVQ KTEAAERCGL HGSYVLRVEA ERLTLLAPGA QRQILEPLLF
210 220 230 240 250
WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND IFQAVETAIH
260 270 280 290 300
RQKIQGKAGQ GQDVLRADSH EGEVADGKLA SLAAPLELPG SPPALYSEPL
310 320 330 340 350
DSLRIPPGPS QDSLYSDPLD STPARAGEGT QLKKALYWDL CEHVQQKLIK
360 370 380 390 400
AKLTDPKEDP IYDEPEGLAP ATLRGLYDLP QEPKDAWWCQ ARVKEEGYEL
410 420 430 440 450
PYNPAMDDYA VPPPRSTKPF PAPKPQGLAL SESGAATGSG SQGHSSDTAL
460 470 480
YSQVQKSGAS GSWDCGLSGV VTDRTGAKSE GST
Length:483
Mass (Da):52,206
Last modified:March 15, 2005 - v1
Checksum:i46A4BCFEFC0B3696
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020685 mRNA. Translation: AAX08702.1.
RefSeqiNP_001019714.2. NM_001024543.2.
UniGeneiBt.26529.

Genome annotation databases

GeneIDi514962.
KEGGibta:514962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020685 mRNA. Translation: AAX08702.1.
RefSeqiNP_001019714.2. NM_001024543.2.
UniGeneiBt.26529.

3D structure databases

ProteinModelPortaliQ5EA84.
SMRiQ5EA84. Positions 153-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024727.

Proteomic databases

PaxDbiQ5EA84.
PRIDEiQ5EA84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514962.
KEGGibta:514962.

Organism-specific databases

CTDi1796.

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
HOGENOMiHOG000112245.
HOVERGENiHBG018962.
InParanoidiQ5EA84.
KOiK14752.

Miscellaneous databases

NextBioi20871594.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDOK1_BOVIN
AccessioniPrimary (citable) accession number: Q5EA84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 15, 2005
Last modified: January 20, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.