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Protein

Histidine decarboxylase

Gene

HDC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the biosynthesis of histamine from histidine.By similarity

Catalytic activityi

L-histidine = histamine + CO2.

Cofactori

Pathwayi: histamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.
Proteins known to be involved in this subpathway in this organism are:
  1. Histidine decarboxylase (HDC)
This subpathway is part of the pathway histamine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811Substrate; via amide nitrogenBy similarity
Binding sitei194 – 1941SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Catecholamine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-BTA-70921. Histidine catabolism.
UniPathwayiUPA00822; UER00786.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
Gene namesi
Name:HDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658Histidine decarboxylasePRO_0000146949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei305 – 3051N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ5EA83.
PRIDEiQ5EA83.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013083.

Structurei

3D structure databases

ProteinModelPortaliQ5EA83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiQ5EA83.
KOiK01590.
OMAiPEHFLHH.
OrthoDBiEOG75B851.
TreeFamiTF313863.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEPEEYRER GKEMVDYICQ YLTTVRERRV TPDVRPGYLR AQLPESAPME
60 70 80 90 100
PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN
110 120 130 140 150
CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPGS QGGGVLQSTV
160 170 180 190 200
SESTLIALLA ARKNKILEMK ASEPEADESF LNARLVAYAS DQAHSSVEKA
210 220 230 240 250
GLISLVKMKF LPVDENFSLR GEALQKAIKE DRERGLVPIF VCATLGTTGV
260 270 280 290 300
CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT
310 320 330 340 350
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV DPVYLRHADS GVATDFMHWQ
360 370 380 390 400
IPLSRRFRSI KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPFFEI
410 420 430 440 450
PAKRHLGLVV FRLKGPNCLT ESVLKEIAKA GRLFLIPATI QDKLIIRFTV
460 470 480 490 500
TSQFTTRDDI LRDWNLIQDA ATLILSQHCT SQPSPQGANL ILQTRGPRAL
510 520 530 540 550
AKEMSFPSVN GAGDDPAHSR KIVMQPPRVG ASPVSRHLET LLDPLDDCFS
560 570 580 590 600
EEAPDVTEHK LSSFLFSYLS VQNKRKAVRS LSCNSVPVSA QKQLTTEGSV
610 620 630 640 650
KNGSSSRVRI FSRFPEEVMM LKKSAFKKLI KFYSVPNFPE CSSQCGLQLP

CCPLQAMV
Length:658
Mass (Da):73,912
Last modified:March 15, 2005 - v1
Checksum:iF458FD059B4CB0C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020686 mRNA. Translation: AAX08703.1.
RefSeqiNP_001019722.1. NM_001024551.1.
UniGeneiBt.37167.

Genome annotation databases

EnsembliENSBTAT00000013083; ENSBTAP00000013083; ENSBTAG00000009911.
GeneIDi515950.
KEGGibta:515950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020686 mRNA. Translation: AAX08703.1.
RefSeqiNP_001019722.1. NM_001024551.1.
UniGeneiBt.37167.

3D structure databases

ProteinModelPortaliQ5EA83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013083.

Proteomic databases

PaxDbiQ5EA83.
PRIDEiQ5EA83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013083; ENSBTAP00000013083; ENSBTAG00000009911.
GeneIDi515950.
KEGGibta:515950.

Organism-specific databases

CTDi3067.

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000121941.
HOVERGENiHBG000944.
InParanoidiQ5EA83.
KOiK01590.
OMAiPEHFLHH.
OrthoDBiEOG75B851.
TreeFamiTF313863.

Enzyme and pathway databases

UniPathwayiUPA00822; UER00786.
ReactomeiR-BTA-70921. Histidine catabolism.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDCHS_BOVIN
AccessioniPrimary (citable) accession number: Q5EA83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.