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Protein

Histidine decarboxylase

Gene

HDC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the biosynthesis of histamine from histidine.By similarity

Catalytic activityi

L-histidine = histamine + CO2.

Cofactori

Pathwayi: histamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.
Proteins known to be involved in this subpathway in this organism are:
  1. Histidine decarboxylase (HDC)
This subpathway is part of the pathway histamine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Substrate; via amide nitrogenBy similarity1
Binding sitei194SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCatecholamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-BTA-70921 Histidine catabolism
UniPathwayiUPA00822; UER00786

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
Gene namesi
Name:HDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:29784 HDC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469491 – 658Histidine decarboxylaseAdd BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ5EA83
PRIDEiQ5EA83

Expressioni

Gene expression databases

BgeeiENSBTAG00000009911

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013083

Structurei

3D structure databases

ProteinModelPortaliQ5EA83
SMRiQ5EA83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000121941
HOVERGENiHBG000944
InParanoidiQ5EA83
KOiK01590
OMAiELEMNVM
OrthoDBiEOG091G03KI
TreeFamiTF313863

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5EA83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEPEEYRER GKEMVDYICQ YLTTVRERRV TPDVRPGYLR AQLPESAPME
60 70 80 90 100
PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN
110 120 130 140 150
CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPGS QGGGVLQSTV
160 170 180 190 200
SESTLIALLA ARKNKILEMK ASEPEADESF LNARLVAYAS DQAHSSVEKA
210 220 230 240 250
GLISLVKMKF LPVDENFSLR GEALQKAIKE DRERGLVPIF VCATLGTTGV
260 270 280 290 300
CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT
310 320 330 340 350
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV DPVYLRHADS GVATDFMHWQ
360 370 380 390 400
IPLSRRFRSI KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPFFEI
410 420 430 440 450
PAKRHLGLVV FRLKGPNCLT ESVLKEIAKA GRLFLIPATI QDKLIIRFTV
460 470 480 490 500
TSQFTTRDDI LRDWNLIQDA ATLILSQHCT SQPSPQGANL ILQTRGPRAL
510 520 530 540 550
AKEMSFPSVN GAGDDPAHSR KIVMQPPRVG ASPVSRHLET LLDPLDDCFS
560 570 580 590 600
EEAPDVTEHK LSSFLFSYLS VQNKRKAVRS LSCNSVPVSA QKQLTTEGSV
610 620 630 640 650
KNGSSSRVRI FSRFPEEVMM LKKSAFKKLI KFYSVPNFPE CSSQCGLQLP

CCPLQAMV
Length:658
Mass (Da):73,912
Last modified:March 15, 2005 - v1
Checksum:iF458FD059B4CB0C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020686 mRNA Translation: AAX08703.1
RefSeqiNP_001019722.1, NM_001024551.1
UniGeneiBt.37167

Genome annotation databases

EnsembliENSBTAT00000013083; ENSBTAP00000013083; ENSBTAG00000009911
GeneIDi515950
KEGGibta:515950

Similar proteinsi

Entry informationi

Entry nameiDCHS_BOVIN
AccessioniPrimary (citable) accession number: Q5EA83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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