HDC

Functionⁱ

Catalyzes the biosynthesis of histamine from histidine.By similarity

Catalytic activityⁱ

L-histidine = histamine + CO₂.

Cofactorⁱ

Pathwayⁱ: histamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.
Proteins known to be involved in this subpathway in this organism are:

Histidine decarboxylase (HDC)

This subpathway is part of the pathway histamine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	81	Substrate; via amide nitrogenBy similarity		1
Binding siteⁱ	194	SubstrateBy similarity		1

GO - Molecular functionⁱ

histidine decarboxylase activity Source: UniProtKB
pyridoxal phosphate binding Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

catecholamine biosynthetic process Source: UniProtKB-KW
histamine biosynthetic process Source: UniProtKB
histidine catabolic process Source: UniProtKB

Complete GO annotation...

Keywordsⁱ

Molecular function	Decarboxylase, Lyase
Biological process	Catecholamine biosynthesis
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

Reactomeⁱ	R-BTA-70921. Histidine catabolism.
UniPathwayⁱ	UPA00822; UER00786.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histidine decarboxylase (EC:4.1.1.22) Short name: HDC
Gene namesⁱ	Name:HDC
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 10

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000146949	1 – 658	Histidine decarboxylaseAdd BLAST		658

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	305	N6-(pyridoxal phosphate)lysineBy similarity		1

Proteomic databases

PaxDbⁱ	Q5EA83.

PaxDbⁱ

Q5EA83.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSBTAG00000009911.

Bgeeⁱ

ENSBTAG00000009911.

Interactionⁱ

Subunit structureⁱ

Homodimer.By similarity

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000013083.

STRINGⁱ

9913.ENSBTAP00000013083.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5EA83.
SMRⁱ	Q5EA83.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0628. Eukaryota. COG0076. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119205.
HOGENOMⁱ	HOG000121941.
HOVERGENⁱ	HBG000944.
InParanoidⁱ	Q5EA83.
KEGG Orthology (KO) More...KOⁱ	K01590.
OMAⁱ	MRYIEAD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03KI.
TreeFamⁱ	TF313863.

Family and domain databases

Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterProⁱ	View protein in InterPro IPR010977. Aromatic_deC. IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_sub2. IPR021115. Pyridoxal-P_BS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00282. Pyridoxal_deC. 1 hit.
PRINTSⁱ	PR00800. YHDCRBOXLASE.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00392. DDC_GAD_HDC_YDC. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5EA83-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMEPEEYRER GKEMVDYICQ YLTTVRERRV TPDVRPGYLR AQLPESAPME 
        60         70         80         90        100
PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN 
       110        120        130        140        150
CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPGS QGGGVLQSTV 
       160        170        180        190        200
SESTLIALLA ARKNKILEMK ASEPEADESF LNARLVAYAS DQAHSSVEKA 
       210        220        230        240        250
GLISLVKMKF LPVDENFSLR GEALQKAIKE DRERGLVPIF VCATLGTTGV 
       260        270        280        290        300
CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT 
       310        320        330        340        350
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV DPVYLRHADS GVATDFMHWQ 
       360        370        380        390        400
IPLSRRFRSI KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPFFEI 
       410        420        430        440        450
PAKRHLGLVV FRLKGPNCLT ESVLKEIAKA GRLFLIPATI QDKLIIRFTV 
       460        470        480        490        500
TSQFTTRDDI LRDWNLIQDA ATLILSQHCT SQPSPQGANL ILQTRGPRAL 
       510        520        530        540        550
AKEMSFPSVN GAGDDPAHSR KIVMQPPRVG ASPVSRHLET LLDPLDDCFS 
       560        570        580        590        600
EEAPDVTEHK LSSFLFSYLS VQNKRKAVRS LSCNSVPVSA QKQLTTEGSV 
       610        620        630        640        650
KNGSSSRVRI FSRFPEEVMM LKKSAFKKLI KFYSVPNFPE CSSQCGLQLP 

CCPLQAMV

Length:658

Mass (Da):73,912

Last modified:March 15, 2005 - v1

Checksum:ⁱF458FD059B4CB0C3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT020686 mRNA. Translation: AAX08703.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001019722.1. NM_001024551.1.
UniGeneⁱ	Bt.37167.

Genome annotation databases

Ensemblⁱ	ENSBTAT00000013083; ENSBTAP00000013083; ENSBTAG00000009911.
GeneIDⁱ	515950.
KEGGⁱ	bta:515950.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5EA83	UPI00072E8C20 UPI00072EC6E9 UPI0009478A64 UPI00042C73D1 UPI00018B8AF5 UPI0009525DB1 UPI0002BD10F5 UPI00062B966F UPI00044033F1 UPI000441ACBF +6	Bos taurus (Bovine) Acinonyx jubatus (Cheetah) Ailuropoda melanoleuca (Giant panda) Physeter catodon (Sperm whale) (Physeter macrocephalus) Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) Orcinus orca (Killer whale) Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) Lipotes vexillifer (Yangtze river dolphin) Bos mutus (wild yak) Bubalus bubalis (Domestic water buffalo) And more	658	UniRef90_Q5EA83	Cluster: Histidine decarboxylase	17

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5EA83	P19113 UPI0007622759 UPI00045E2BFE M3Y942 UPI000652EF1B G9K3Y2 G9K3Y1 F7HZT5 UPI0005F4C282 UPI0009816BEE +121	Homo sapiens (Human) Marmota marmota marmota (Alpine marmot) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Mustela putorius furo (European domestic ferret) (Mustela furo) Callithrix jacchus (White-tufted-ear marmoset) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Castor canadensis (Beaver) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Macaca mulatta (Rhesus macaque) Colobus angolensis palliatus (Peters' Angolan colobus) And more	662	UniRef50_P19113	Cluster: Histidine decarboxylase	132

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT020686 mRNA. Translation: AAX08703.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001019722.1. NM_001024551.1.
UniGeneⁱ	Bt.37167.

3D structure databases

ProteinModelPortalⁱ	Q5EA83.
SMRⁱ	Q5EA83.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9913.ENSBTAP00000013083.

STRINGⁱ

9913.ENSBTAP00000013083.

Proteomic databases

PaxDbⁱ	Q5EA83.

PaxDbⁱ

Q5EA83.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000013083; ENSBTAP00000013083; ENSBTAG00000009911.
GeneIDⁱ	515950.
KEGGⁱ	bta:515950.

Organism-specific databases

CTDⁱ	3067.

CTDⁱ

3067.

Phylogenomic databases

eggNOGⁱ	KOG0628. Eukaryota. COG0076. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119205.
HOGENOMⁱ	HOG000121941.
HOVERGENⁱ	HBG000944.
InParanoidⁱ	Q5EA83.
KEGG Orthology (KO) More...KOⁱ	K01590.
OMAⁱ	MRYIEAD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03KI.
TreeFamⁱ	TF313863.

Enzyme and pathway databases

UniPathwayⁱ	UPA00822; UER00786.
Reactomeⁱ	R-BTA-70921. Histidine catabolism.

Gene expression databases

Bgeeⁱ	ENSBTAG00000009911.

Bgeeⁱ

ENSBTAG00000009911.

Family and domain databases

Gene3Dⁱ	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterProⁱ	View protein in InterPro IPR010977. Aromatic_deC. IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_sub2. IPR021115. Pyridoxal-P_BS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00282. Pyridoxal_deC. 1 hit.
PRINTSⁱ	PR00800. YHDCRBOXLASE.
SUPFAMⁱ	SSF53383. SSF53383. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00392. DDC_GAD_HDC_YDC. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DCHS_BOVIN
Accessionⁱ	Q5EA83Primary (citable) accession number: Q5EA83
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
	Last sequence update:	March 15, 2005
	Last modified:	August 30, 2017
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q5EA83 (DCHS_BOVIN)

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Histidine decarboxylase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: histamine biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: histamine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ