UniProtKB - Q5EA83 (DCHS_BOVIN)
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Protein
Histidine decarboxylase
Gene
HDC
Organism
Bos taurus (Bovine)
Status
Functioni
Catalyzes the biosynthesis of histamine from histidine.By similarity
Catalytic activityi
L-histidine = histamine + CO2.
Cofactori
pyridoxal 5'-phosphateBy similarity
: histamine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.Proteins known to be involved in this subpathway in this organism are:
- Histidine decarboxylase (HDC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 81 | Substrate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 194 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- histidine decarboxylase activity Source: UniProtKB
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- catecholamine biosynthetic process Source: UniProtKB-KW
- histamine biosynthetic process Source: UniProtKB
- histidine catabolic process Source: UniProtKB
Keywordsi
Molecular function | Decarboxylase, Lyase |
Biological process | Catecholamine biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
Reactomei | R-BTA-70921 Histidine catabolism |
UniPathwayi | UPA00822; UER00786 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HDC |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:29784 HDC |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146949 | 1 – 658 | Histidine decarboxylaseAdd BLAST | 658 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 305 | N6-(pyridoxal phosphate)lysineBy similarity | 1 |
Proteomic databases
PaxDbi | Q5EA83 |
Interactioni
Subunit structurei
Homodimer.By similarity
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000013083 |
Structurei
3D structure databases
ProteinModelPortali | Q5EA83 |
SMRi | Q5EA83 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the group II decarboxylase family.Curated
Phylogenomic databases
eggNOGi | KOG0628 Eukaryota COG0076 LUCA |
GeneTreei | ENSGT00760000119205 |
HOGENOMi | HOG000121941 |
HOVERGENi | HBG000944 |
InParanoidi | Q5EA83 |
KOi | K01590 |
OMAi | ELEMNVM |
OrthoDBi | EOG091G03KI |
TreeFami | TF313863 |
Family and domain databases
Gene3Di | 3.40.640.101 hit 3.90.1150.101 hit |
InterProi | View protein in InterPro IPR010977 Aromatic_deC IPR002129 PyrdxlP-dep_de-COase IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major IPR021115 Pyridoxal-P_BS |
Pfami | View protein in Pfam PF00282 Pyridoxal_deC, 1 hit |
PRINTSi | PR00800 YHDCRBOXLASE |
SUPFAMi | SSF53383 SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00392 DDC_GAD_HDC_YDC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5EA83-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMEPEEYRER GKEMVDYICQ YLTTVRERRV TPDVRPGYLR AQLPESAPME
60 70 80 90 100
PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN
110 120 130 140 150
CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPGS QGGGVLQSTV
160 170 180 190 200
SESTLIALLA ARKNKILEMK ASEPEADESF LNARLVAYAS DQAHSSVEKA
210 220 230 240 250
GLISLVKMKF LPVDENFSLR GEALQKAIKE DRERGLVPIF VCATLGTTGV
260 270 280 290 300
CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT
310 320 330 340 350
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV DPVYLRHADS GVATDFMHWQ
360 370 380 390 400
IPLSRRFRSI KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPFFEI
410 420 430 440 450
PAKRHLGLVV FRLKGPNCLT ESVLKEIAKA GRLFLIPATI QDKLIIRFTV
460 470 480 490 500
TSQFTTRDDI LRDWNLIQDA ATLILSQHCT SQPSPQGANL ILQTRGPRAL
510 520 530 540 550
AKEMSFPSVN GAGDDPAHSR KIVMQPPRVG ASPVSRHLET LLDPLDDCFS
560 570 580 590 600
EEAPDVTEHK LSSFLFSYLS VQNKRKAVRS LSCNSVPVSA QKQLTTEGSV
610 620 630 640 650
KNGSSSRVRI FSRFPEEVMM LKKSAFKKLI KFYSVPNFPE CSSQCGLQLP
CCPLQAMV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT020686 mRNA Translation: AAX08703.1 |
RefSeqi | NP_001019722.1, NM_001024551.1 |
UniGenei | Bt.37167 |
Genome annotation databases
Ensembli | ENSBTAT00000013083; ENSBTAP00000013083; ENSBTAG00000009911 |
GeneIDi | 515950 |
KEGGi | bta:515950 |
Similar proteinsi
Entry informationi
Entry namei | DCHS_BOVIN | |
Accessioni | Q5EA83Primary (citable) accession number: Q5EA83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | March 28, 2018 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |