Reviewed, UniProtKB/Swiss-Prot Q5EA80 (PGTA_BOVIN)

Names and origin

Protein names

Recommended name:
    Geranylgeranyl transferase type-2 subunit alpha
    EC=2.5.1.60
Alternative name(s):
    Geranylgeranyl transferase type II subunit alpha
    Rab geranylgeranyltransferase subunit alpha
    Rab geranyl-geranyltransferase subunit alpha
      Short name=Rab GG transferase alpha
      Short name=Rab GGTase alpha

Gene names

Name:

RABGGTA

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively By similarity.
Catalytic activity	Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Cofactor	Binds 1 zinc ion per dimer By similarity.
Enzyme regulation	The enzymatic reaction requires the aid of a Rab escort protein (also called component A) By similarity.
Subunit structure	Heterodimer of an alpha and a beta subunit, collectively called component B By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit alpha family. Contains 6 PFTA repeats.

Ontologies

Keywords
Domain	Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
Gene Ontology (GO)
Biological process	protein amino acid prenylation Inferred from electronic annotation. Source: InterPro
Molecular function	Rab geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 567	567	Geranylgeranyl transferase type-2 subunit alpha		PRO_0000244431
Regions
	Repeat	44 – 78	35	PFTA 1
	Repeat	88 – 122	35	PFTA 2
	Repeat	124 – 158	35	PFTA 3
	Repeat	159 – 193	35	PFTA 4
	Repeat	207 – 241	35	PFTA 5
	Repeat	363 – 397	35	PFTA 6
Sites
	Metal binding	2	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5EA80-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 062DF9E97F366B3B	FASTA	567	64,945
	10 20 30 40 50 60 MHGRLKVKTS EEQAEAKRLE REQKLKLYQA ATQTVFQKRQ AGELDESVLE LTSQILGANP 70 80 90 100 110 120 DFATLWNCRR EVLQQLEVQK SPEELATLVK AELGFLESCL RVNPKSYGTW HHRCWLLSRL 130 140 150 160 170 180 PEPNWARELE LCARFLEVDE RNFHCWDYRR FVAAQAAVPP AEELAFTDSL ITRNFSNYSS 190 200 210 220 230 240 WHYRSCLLPQ LHPQPDSGPQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD 250 260 270 280 290 300 PQDALRCLHV SRDEACLTVS FSRPLLVGSG METLLLMVDE SPLAVEWRTP EGRNRPSHIW 310 320 330 340 350 360 LCDLPATSLN DQLPQHTFRV IWTAGDAQKE CVLLKGRQEG WCRDSATDEQ LFRCELSVEK 370 380 390 400 410 420 STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLQY EKETLQYFQT LKAVDPMRAA 430 440 450 460 470 480 YLDDLRSKFL LENSVLKMEY AEVRVLHLGH KDLTVLCHLE QLLLVTHLDL SHNRLRALPP 490 500 510 520 530 540 ALAALRCLEV LQANDNAIES LDGVTNLPRL QELILCNNRL QQPAVLQPLT SCPRLTLLNL 550 560 QGNPLCQAEG SSEHLAELLP SVSSILT

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BT020689 mRNA. Translation: AAX08706.1. BT020760 mRNA. Translation: AAX08777.1. BT020911 mRNA. Translation: AAX08928.1. BC111228 mRNA. Translation: AAI11229.1. BT020650 mRNA. Translation: AAX08667.1.
IPI	IPI00717057.
RefSeq	NP_001015614.1.
UniGene	Bt.7696
3D structure databases
SMR	Q5EA80. Positions 2-567.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5EA80.
Genome annotation databases
Ensembl	ENSBTAT00000025020; ENSBTAP00000025020; ENSBTAG00000018796; Bos taurus. [Genome view]
GeneID	516619.
KEGG	bta:516619.
Organism-specific databases
CTD	516619.
Phylogenomic databases
HOVERGEN	Q5EA80.
OMA	WHYRSCL.
Enzyme and pathway databases
BRENDA	2.5.1.60. 251.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. IPR009087. RabGG_trans_A. [Graphical view]
Gene3D	G3DSA:1.25.40.120. Prenyl_trans. 1 hit.
Pfam	PF00560. LRR_1. 1 hit. PF01239. PPTA. 6 hits. PF07711. RabGGT_insert. 1 hit. [Graphical view]
PROSITE	PS51147. PFTA. 6 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGTA_BOVIN

Accession

Primary (citable) accession number: Q5EA80

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 15, 2005
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)