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Q5EA80

- PGTA_BOVIN

UniProt

Q5EA80 - PGTA_BOVIN

Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

RABGGTA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.By similarity

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

    Enzyme regulationi

    The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.By similarity

    GO - Molecular functioni

    1. Rab geranylgeranyltransferase activity Source: UniProtKB
    2. Rab GTPase binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein geranylgeranylation Source: UniProtKB

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
    Alternative name(s):
    Geranylgeranyl transferase type II subunit alpha
    Rab geranyl-geranyltransferase subunit alpha
    Short name:
    Rab GG transferase alpha
    Short name:
    Rab GGTase alpha
    Rab geranylgeranyltransferase subunit alpha
    Gene namesi
    Name:RABGGTA
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 10

    Subcellular locationi

    GO - Cellular componenti

    1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Geranylgeranyl transferase type-2 subunit alphaPRO_0000244431Add
    BLAST

    Proteomic databases

    PRIDEiQ5EA80.

    Interactioni

    Subunit structurei

    Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5EA80.
    SMRiQ5EA80. Positions 2-567.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati44 – 7835PFTA 1Add
    BLAST
    Repeati88 – 12235PFTA 2Add
    BLAST
    Repeati124 – 15835PFTA 3Add
    BLAST
    Repeati159 – 19335PFTA 4Add
    BLAST
    Repeati207 – 24135PFTA 5Add
    BLAST
    Repeati363 – 39735PFTA 6Add
    BLAST
    Repeati442 – 46322LRR 1Add
    BLAST
    Repeati464 – 48623LRR 2Add
    BLAST
    Repeati487 – 50822LRR 3Add
    BLAST
    Repeati509 – 53022LRR 4Add
    BLAST
    Repeati534 – 55522LRR 5Add
    BLAST

    Sequence similaritiesi

    Contains 5 LRR (leucine-rich) repeats.Curated
    Contains 6 PFTA repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG5536.
    GeneTreeiENSGT00550000075121.
    HOGENOMiHOG000007845.
    HOVERGENiHBG002171.
    InParanoidiQ5EA80.
    KOiK14050.
    OMAiWNCRREV.
    OrthoDBiEOG7PP56C.
    TreeFamiTF315057.

    Family and domain databases

    Gene3Di2.60.40.1130. 1 hit.
    InterProiIPR001611. Leu-rich_rpt.
    IPR002088. Prenyl_trans_a.
    IPR009087. RabGGT_asu_insert-domain.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF01239. PPTA. 5 hits.
    PF07711. RabGGT_insert. 1 hit.
    [Graphical view]
    ProDomiPD331837. RabGG_trans_A. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF49594. SSF49594. 1 hit.
    PROSITEiPS51147. PFTA. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5EA80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHGRLKVKTS EEQAEAKRLE REQKLKLYQA ATQTVFQKRQ AGELDESVLE    50
    LTSQILGANP DFATLWNCRR EVLQQLEVQK SPEELATLVK AELGFLESCL 100
    RVNPKSYGTW HHRCWLLSRL PEPNWARELE LCARFLEVDE RNFHCWDYRR 150
    FVAAQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ 200
    GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV 250
    SRDEACLTVS FSRPLLVGSG METLLLMVDE SPLAVEWRTP EGRNRPSHIW 300
    LCDLPATSLN DQLPQHTFRV IWTAGDAQKE CVLLKGRQEG WCRDSATDEQ 350
    LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLQY 400
    EKETLQYFQT LKAVDPMRAA YLDDLRSKFL LENSVLKMEY AEVRVLHLGH 450
    KDLTVLCHLE QLLLVTHLDL SHNRLRALPP ALAALRCLEV LQANDNAIES 500
    LDGVTNLPRL QELILCNNRL QQPAVLQPLT SCPRLTLLNL QGNPLCQAEG 550
    SSEHLAELLP SVSSILT 567
    Length:567
    Mass (Da):64,945
    Last modified:March 15, 2005 - v1
    Checksum:i062DF9E97F366B3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020689 mRNA. Translation: AAX08706.1.
    BT020760 mRNA. Translation: AAX08777.1.
    BT020911 mRNA. Translation: AAX08928.1.
    BC111228 mRNA. Translation: AAI11229.1.
    BT020650 mRNA. Translation: AAX08667.1.
    RefSeqiNP_001015614.1. NM_001015614.1.
    UniGeneiBt.7696.

    Genome annotation databases

    EnsembliENSBTAT00000025020; ENSBTAP00000025020; ENSBTAG00000018796.
    GeneIDi516619.
    KEGGibta:516619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020689 mRNA. Translation: AAX08706.1 .
    BT020760 mRNA. Translation: AAX08777.1 .
    BT020911 mRNA. Translation: AAX08928.1 .
    BC111228 mRNA. Translation: AAI11229.1 .
    BT020650 mRNA. Translation: AAX08667.1 .
    RefSeqi NP_001015614.1. NM_001015614.1.
    UniGenei Bt.7696.

    3D structure databases

    ProteinModelPortali Q5EA80.
    SMRi Q5EA80. Positions 2-567.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5EA80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000025020 ; ENSBTAP00000025020 ; ENSBTAG00000018796 .
    GeneIDi 516619.
    KEGGi bta:516619.

    Organism-specific databases

    CTDi 5875.

    Phylogenomic databases

    eggNOGi COG5536.
    GeneTreei ENSGT00550000075121.
    HOGENOMi HOG000007845.
    HOVERGENi HBG002171.
    InParanoidi Q5EA80.
    KOi K14050.
    OMAi WNCRREV.
    OrthoDBi EOG7PP56C.
    TreeFami TF315057.

    Miscellaneous databases

    NextBioi 20872272.

    Family and domain databases

    Gene3Di 2.60.40.1130. 1 hit.
    InterProi IPR001611. Leu-rich_rpt.
    IPR002088. Prenyl_trans_a.
    IPR009087. RabGGT_asu_insert-domain.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF01239. PPTA. 5 hits.
    PF07711. RabGGT_insert. 1 hit.
    [Graphical view ]
    ProDomi PD331837. RabGG_trans_A. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF49594. SSF49594. 1 hit.
    PROSITEi PS51147. PFTA. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiPGTA_BOVIN
    AccessioniPrimary (citable) accession number: Q5EA80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3