Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5EA80 (PGTA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Geranylgeranyl transferase type-2 subunit alpha

EC=2.5.1.60
Alternative name(s):
Geranylgeranyl transferase type II subunit alpha
Rab geranyl-geranyltransferase subunit alpha
Short name=Rab GG transferase alpha
Short name=Rab GGTase alpha
Rab geranylgeranyltransferase subunit alpha
Gene names
Name:RABGGTA
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A By similarity.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Enzyme regulation

The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM By similarity.

Subunit structure

Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit alpha family.

Contains 5 LRR (leucine-rich) repeats.

Contains 6 PFTA repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 567567Geranylgeranyl transferase type-2 subunit alpha
PRO_0000244431

Regions

Repeat44 – 7835PFTA 1
Repeat88 – 12235PFTA 2
Repeat124 – 15835PFTA 3
Repeat159 – 19335PFTA 4
Repeat207 – 24135PFTA 5
Repeat363 – 39735PFTA 6
Repeat442 – 46322LRR 1
Repeat464 – 48623LRR 2
Repeat487 – 50822LRR 3
Repeat509 – 53022LRR 4
Repeat534 – 55522LRR 5

Sequences

Sequence LengthMass (Da)Tools
Q5EA80 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 062DF9E97F366B3B

FASTA56764,945
        10         20         30         40         50         60 
MHGRLKVKTS EEQAEAKRLE REQKLKLYQA ATQTVFQKRQ AGELDESVLE LTSQILGANP 

        70         80         90        100        110        120 
DFATLWNCRR EVLQQLEVQK SPEELATLVK AELGFLESCL RVNPKSYGTW HHRCWLLSRL 

       130        140        150        160        170        180 
PEPNWARELE LCARFLEVDE RNFHCWDYRR FVAAQAAVPP AEELAFTDSL ITRNFSNYSS 

       190        200        210        220        230        240 
WHYRSCLLPQ LHPQPDSGPQ GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD 

       250        260        270        280        290        300 
PQDALRCLHV SRDEACLTVS FSRPLLVGSG METLLLMVDE SPLAVEWRTP EGRNRPSHIW 

       310        320        330        340        350        360 
LCDLPATSLN DQLPQHTFRV IWTAGDAQKE CVLLKGRQEG WCRDSATDEQ LFRCELSVEK 

       370        380        390        400        410        420 
STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLQY EKETLQYFQT LKAVDPMRAA 

       430        440        450        460        470        480 
YLDDLRSKFL LENSVLKMEY AEVRVLHLGH KDLTVLCHLE QLLLVTHLDL SHNRLRALPP 

       490        500        510        520        530        540 
ALAALRCLEV LQANDNAIES LDGVTNLPRL QELILCNNRL QQPAVLQPLT SCPRLTLLNL 

       550        560 
QGNPLCQAEG SSEHLAELLP SVSSILT 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT020689 mRNA. Translation: AAX08706.1.
BT020760 mRNA. Translation: AAX08777.1.
BT020911 mRNA. Translation: AAX08928.1.
BC111228 mRNA. Translation: AAI11229.1.
BT020650 mRNA. Translation: AAX08667.1.
RefSeqNP_001015614.1. NM_001015614.1.
UniGeneBt.7696.

3D structure databases

ProteinModelPortalQ5EA80.
SMRQ5EA80. Positions 2-567.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5EA80.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000025020; ENSBTAP00000025020; ENSBTAG00000018796.
GeneID516619.
KEGGbta:516619.

Organism-specific databases

CTD5875.

Phylogenomic databases

eggNOGCOG5536.
GeneTreeENSGT00550000075121.
HOGENOMHOG000007845.
HOVERGENHBG002171.
InParanoidQ5EA80.
KOK14050.
OMAWNCRREV.
OrthoDBEOG7PP56C.
TreeFamTF315057.

Family and domain databases

Gene3D2.60.40.1130. 1 hit.
InterProIPR001611. Leu-rich_rpt.
IPR002088. Prenyl_trans_a.
IPR009087. RabGGT_asu_insert-domain.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
PF01239. PPTA. 5 hits.
PF07711. RabGGT_insert. 1 hit.
[Graphical view]
ProDomPD331837. RabGG_trans_A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF49594. SSF49594. 1 hit.
PROSITEPS51147. PFTA. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20872272.

Entry information

Entry namePGTA_BOVIN
AccessionPrimary (citable) accession number: Q5EA80
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families