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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

RABGGTA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Enzyme regulationi

The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrenyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-BTA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-BTA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit alpha
Rab geranyl-geranyltransferase subunit alpha
Short name:
Rab GG transferase alpha
Short name:
Rab GGTase alpha
Rab geranylgeranyltransferase subunit alpha
Gene namesi
Name:RABGGTA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:33670 RABGGTA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444311 – 567Geranylgeranyl transferase type-2 subunit alphaAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5EA80
PRIDEiQ5EA80

Expressioni

Gene expression databases

BgeeiENSBTAG00000018796
ExpressionAtlasiQ5EA80 baseline

Interactioni

Subunit structurei

Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025020

Structurei

3D structure databases

ProteinModelPortaliQ5EA80
SMRiQ5EA80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 78PFTA 1Add BLAST35
Repeati88 – 122PFTA 2Add BLAST35
Repeati124 – 158PFTA 3Add BLAST35
Repeati159 – 193PFTA 4Add BLAST35
Repeati207 – 241PFTA 5Add BLAST35
Repeati363 – 397PFTA 6Add BLAST35
Repeati442 – 463LRR 1Add BLAST22
Repeati464 – 486LRR 2Add BLAST23
Repeati487 – 508LRR 3Add BLAST22
Repeati509 – 530LRR 4Add BLAST22
Repeati534 – 555LRR 5Add BLAST22

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0529 Eukaryota
COG5536 LUCA
GeneTreeiENSGT00550000075121
HOGENOMiHOG000007845
HOVERGENiHBG002171
InParanoidiQ5EA80
KOiK14050
OMAiMRAAYLD
OrthoDBiEOG091G0L9H
TreeFamiTF315057

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR002088 Prenyl_trans_a
IPR036254 RabGGT_asu_insert-dom_sf
IPR009087 RabGGT_asu_insert-domain
IPR032955 RabGGTase_alpha
PANTHERiPTHR11129:SF2 PTHR11129:SF2, 1 hit
PfamiView protein in Pfam
PF01239 PPTA, 4 hits
PF07711 RabGGT_insert, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD331837 RabGG_trans_A, 1 hit
SUPFAMiSSF49594 SSF49594, 1 hit
PROSITEiView protein in PROSITE
PS51147 PFTA, 6 hits

Sequencei

Sequence statusi: Complete.

Q5EA80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGRLKVKTS EEQAEAKRLE REQKLKLYQA ATQTVFQKRQ AGELDESVLE
60 70 80 90 100
LTSQILGANP DFATLWNCRR EVLQQLEVQK SPEELATLVK AELGFLESCL
110 120 130 140 150
RVNPKSYGTW HHRCWLLSRL PEPNWARELE LCARFLEVDE RNFHCWDYRR
160 170 180 190 200
FVAAQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ
210 220 230 240 250
GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV
260 270 280 290 300
SRDEACLTVS FSRPLLVGSG METLLLMVDE SPLAVEWRTP EGRNRPSHIW
310 320 330 340 350
LCDLPATSLN DQLPQHTFRV IWTAGDAQKE CVLLKGRQEG WCRDSATDEQ
360 370 380 390 400
LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLQY
410 420 430 440 450
EKETLQYFQT LKAVDPMRAA YLDDLRSKFL LENSVLKMEY AEVRVLHLGH
460 470 480 490 500
KDLTVLCHLE QLLLVTHLDL SHNRLRALPP ALAALRCLEV LQANDNAIES
510 520 530 540 550
LDGVTNLPRL QELILCNNRL QQPAVLQPLT SCPRLTLLNL QGNPLCQAEG
560
SSEHLAELLP SVSSILT
Length:567
Mass (Da):64,945
Last modified:March 15, 2005 - v1
Checksum:i062DF9E97F366B3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020689 mRNA Translation: AAX08706.1
BT020760 mRNA Translation: AAX08777.1
BT020911 mRNA Translation: AAX08928.1
BC111228 mRNA Translation: AAI11229.1
BT020650 mRNA Translation: AAX08667.1
RefSeqiNP_001015614.1, NM_001015614.1
UniGeneiBt.7696

Genome annotation databases

EnsembliENSBTAT00000025020; ENSBTAP00000025020; ENSBTAG00000018796
GeneIDi516619
KEGGibta:516619

Similar proteinsi

Entry informationi

Entry nameiPGTA_BOVIN
AccessioniPrimary (citable) accession number: Q5EA80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health