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Protein

Protein transport protein Sec61 subunit alpha isoform 1

Gene

SEC61A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-BTA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit alpha isoform 1
Short name:
Sec61 alpha-1
Gene namesi
Name:SEC61A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 33CytoplasmicSequence analysisAdd BLAST32
Transmembranei34 – 53HelicalSequence analysisAdd BLAST20
Topological domaini54 – 76LumenalSequence analysisAdd BLAST23
Transmembranei77 – 96HelicalSequence analysisAdd BLAST20
Topological domaini97 – 117CytoplasmicSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 144LumenalSequence analysis6
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 172CytoplasmicSequence analysis7
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 240LumenalSequence analysisAdd BLAST47
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 288CytoplasmicSequence analysisAdd BLAST27
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 354LumenalSequence analysisAdd BLAST45
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 420CytoplasmicSequence analysisAdd BLAST45
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Topological domaini442 – 445LumenalSequence analysis4
Transmembranei446 – 462HelicalSequence analysisAdd BLAST17
Topological domaini463 – 476CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002391192 – 476Protein transport protein Sec61 subunit alpha isoform 1Add BLAST475

Proteomic databases

PaxDbiQ5EA68.
PeptideAtlasiQ5EA68.
PRIDEiQ5EA68.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004937.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Protein-protein interaction databases

BioGridi161713. 2 interactors.
STRINGi9913.ENSBTAP00000006494.

Structurei

3D structure databases

ProteinModelPortaliQ5EA68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
GeneTreeiENSGT00390000003721.
HOGENOMiHOG000231249.
HOVERGENiHBG055271.
InParanoidiQ5EA68.
KOiK10956.
OMAiWLRMVMA.
OrthoDBiEOG091G05FO.
TreeFamiTF300348.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EA68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL
60 70 80 90 100
FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
110 120 130 140 150
EVGDTPKDRA LFNGAQKLFG MTITIGQSIV YVMTGMYGDP SEMGAGVCLL
160 170 180 190 200
ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
210 220 230 240 250
VNTGRGMEFE GAIIALFHLL ATRTDKVRAL REAFYRQNLP NLMNLIATIF
260 270 280 290 300
VFAVVIYFQG FRVDLPIKSA RYRGQYNTYP IKLFYTSNIP IILQSALVSN
310 320 330 340 350
LYVISQMLSA RFSGNLLVSL LGTWSDTSSG GPARAYPVGG LCYYLSPPES
360 370 380 390 400
FGSVLEDPVH AVVYIVFMLG SCAFFSKTWI EVSGSSAKDV AKQLKEQQMV
410 420 430 440 450
MRGHRETSMV HELNRYIPTA AAFGGLCIGA LSVLADFLGA IGSGTGILLA
460 470
VTIIYQYFEI FVKEQSEVGS MGALLF
Length:476
Mass (Da):52,225
Last modified:January 23, 2007 - v3
Checksum:i17CA223E8721BC6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020701 mRNA. Translation: AAX08718.1.
BC151365 mRNA. Translation: AAI51366.1.
RefSeqiNP_001035594.1. NM_001040504.1.
UniGeneiBt.21836.

Genome annotation databases

EnsembliENSBTAT00000006494; ENSBTAP00000006494; ENSBTAG00000004937.
GeneIDi505064.
KEGGibta:505064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020701 mRNA. Translation: AAX08718.1.
BC151365 mRNA. Translation: AAI51366.1.
RefSeqiNP_001035594.1. NM_001040504.1.
UniGeneiBt.21836.

3D structure databases

ProteinModelPortaliQ5EA68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi161713. 2 interactors.
STRINGi9913.ENSBTAP00000006494.

Proteomic databases

PaxDbiQ5EA68.
PeptideAtlasiQ5EA68.
PRIDEiQ5EA68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006494; ENSBTAP00000006494; ENSBTAG00000004937.
GeneIDi505064.
KEGGibta:505064.

Organism-specific databases

CTDi29927.

Phylogenomic databases

eggNOGiKOG1373. Eukaryota.
COG0201. LUCA.
GeneTreeiENSGT00390000003721.
HOGENOMiHOG000231249.
HOVERGENiHBG055271.
InParanoidiQ5EA68.
KOiK10956.
OMAiWLRMVMA.
OrthoDBiEOG091G05FO.
TreeFamiTF300348.

Enzyme and pathway databases

ReactomeiR-BTA-381038. XBP1(S) activates chaperone genes.

Gene expression databases

BgeeiENSBTAG00000004937.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS61A1_BOVIN
AccessioniPrimary (citable) accession number: Q5EA68
Secondary accession number(s): A9JSM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.