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Q5EA65

- GPT_BOVIN

UniProt

Q5EA65 - GPT_BOVIN

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Protein

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Gene
DPAGT1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.

Pathwayi

GO - Molecular functioni

  1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: InterPro
  2. transferase activity, transferring glycosyl groups Source: UniProtKB-KW
  3. UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity Source: UniProtKB

GO - Biological processi

  1. dolichol biosynthetic process Source: UniProtKB
  2. protein N-linked glycosylation Source: Ensembl
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_220681. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.
UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC:2.7.8.15)
Alternative name(s):
GlcNAc-1-P transferase
Short name:
G1PT
Short name:
GPT
N-acetylglucosamine-1-phosphate transferase
Gene namesi
Name:DPAGT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 15

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Lumenal Reviewed prediction
Transmembranei7 – 3226Helical; Reviewed predictionAdd
BLAST
Topological domaini33 – 5725Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei58 – 7922Helical; Reviewed predictionAdd
BLAST
Topological domaini80 – 9415Lumenal Reviewed predictionAdd
BLAST
Transmembranei95 – 11420Helical; Reviewed predictionAdd
BLAST
Topological domaini115 – 12511Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei126 – 14520Helical; Reviewed predictionAdd
BLAST
Topological domaini146 – 16419Lumenal Reviewed predictionAdd
BLAST
Transmembranei165 – 18420Helical; Reviewed predictionAdd
BLAST
Topological domaini185 – 19410Cytoplasmic Reviewed prediction
Transmembranei195 – 21117Helical; Reviewed predictionAdd
BLAST
Topological domaini212 – 22110Lumenal Reviewed prediction
Transmembranei222 – 24019Helical; Reviewed predictionAdd
BLAST
Topological domaini241 – 25212Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei253 – 26917Helical; Reviewed predictionAdd
BLAST
Topological domaini270 – 2745Lumenal Reviewed prediction
Transmembranei275 – 29420Helical; Reviewed predictionAdd
BLAST
Topological domaini295 – 37884Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei379 – 39719Helical; Reviewed predictionAdd
BLAST
Topological domaini398 – 40811Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferasePRO_0000314781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5EA65.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 7913Dolichol recognitionAdd
BLAST
Motifi222 – 23413Dolichol recognitionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0472.
GeneTreeiENSGT00390000011424.
HOGENOMiHOG000163915.
HOVERGENiHBG000846.
InParanoidiQ5EA65.
KOiK01001.
OMAiIHERNLT.
OrthoDBiEOG73804W.
TreeFamiTF313734.

Family and domain databases

InterProiIPR000715. Glycosyl_transferase_4.
[Graphical view]
PfamiPF00953. Glycos_transf_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA65-1 [UniParc]FASTAAdd to Basket

« Hide

MWAFPELPMP LLVNLIGSLM GFVATVTLIP AFRGHFIAAR LCGQDLNKSS    50
REQIPESQGV ISGAVFLIIL FCFIPFPFLN CFVEQQCKAF PHHEFVALIG 100
ALLAICCMIF LGFADDVLNL RWRHKLLLPT AASLPLLMVY FTNFGNTTIV 150
VPKPLRPILG LHLDLGILYY VYMGLLAVFC TNAINILAGI NGLEAGQSLV 200
ISASIIVFNL VELDGDYRDD HIFSLYFMIP FFFTTLGLLY HNWYPSRVFV 250
GDTFCYFAGM TFAVVGILGH FSKTMLLFFM PQVFNFLYSL PQLLHIIPCP 300
RHRMPRLNTK TGKLEMSYSK FKTKSLSFLG TFILKVAENL GLLTVRHSED 350
EDGAFTECNN MTLINLLLKV FGPMHERNLT LLLLLLQVVG SAVTFSIRYQ 400
LVRLFYDV 408
Length:408
Mass (Da):46,045
Last modified:March 15, 2005 - v1
Checksum:i9BD875493287FB1C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti312 – 3121G → D in AAI02418. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020704 mRNA. Translation: AAX08721.1.
BC102417 mRNA. Translation: AAI02418.1.
RefSeqiNP_001015664.1. NM_001015664.1.
UniGeneiBt.5711.

Genome annotation databases

EnsembliENSBTAT00000007065; ENSBTAP00000007065; ENSBTAG00000005371.
GeneIDi537812.
KEGGibta:537812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020704 mRNA. Translation: AAX08721.1 .
BC102417 mRNA. Translation: AAI02418.1 .
RefSeqi NP_001015664.1. NM_001015664.1.
UniGenei Bt.5711.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5EA65.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000007065 ; ENSBTAP00000007065 ; ENSBTAG00000005371 .
GeneIDi 537812.
KEGGi bta:537812.

Organism-specific databases

CTDi 1798.

Phylogenomic databases

eggNOGi COG0472.
GeneTreei ENSGT00390000011424.
HOGENOMi HOG000163915.
HOVERGENi HBG000846.
InParanoidi Q5EA65.
KOi K01001.
OMAi IHERNLT.
OrthoDBi EOG73804W.
TreeFami TF313734.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_220681. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

Miscellaneous databases

NextBioi 20877222.

Family and domain databases

InterProi IPR000715. Glycosyl_transferase_4.
[Graphical view ]
Pfami PF00953. Glycos_transf_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiGPT_BOVIN
AccessioniPrimary (citable) accession number: Q5EA65
Secondary accession number(s): Q3T0F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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