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Q5EA61

- KCRB_BOVIN

UniProt

Q5EA61 - KCRB_BOVIN

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Protein
Creatine kinase B-type
Gene
CKB
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa By similarity.

Catalytic activityi

ATP + creatine = ADP + phosphocreatine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301ATP By similarity
Binding sitei132 – 1321ATP By similarity
Binding sitei191 – 1911ATP By similarity
Binding sitei232 – 2321Substrate By similarity
Binding sitei236 – 2361ATP By similarity
Binding sitei285 – 2851Substrate By similarity
Binding sitei292 – 2921ATP By similarity
Binding sitei320 – 3201ATP By similarity
Binding sitei335 – 3351ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi128 – 1325ATP By similarity
Nucleotide bindingi320 – 3256ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. creatine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. brain development Source: AgBase
  2. cellular chloride ion homeostasis Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_207339. Creatine metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Creatine kinase B-type (EC:2.7.3.2)
Alternative name(s):
B-CK
Creatine kinase B chain
Gene namesi
Name:CKB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 21

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. mitochondrion Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 381380Creatine kinase B-type
PRO_0000244732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41Phosphoserine By similarity
Modified residuei35 – 351Phosphothreonine By similarity
Modified residuei125 – 1251Phosphotyrosine By similarity
Modified residuei199 – 1991Phosphoserine By similarity
Modified residuei269 – 2691Nitrated tyrosine By similarity

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

PaxDbiQ5EA61.
PRIDEiQ5EA61.

Interactioni

Subunit structurei

Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004079.

Structurei

3D structure databases

ProteinModelPortaliQ5EA61.
SMRiQ5EA61. Positions 2-381.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9888Phosphagen kinase N-terminal
Add
BLAST
Domaini125 – 367243Phosphagen kinase C-terminal
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3869.
GeneTreeiENSGT00550000074561.
HOGENOMiHOG000232165.
HOVERGENiHBG001339.
InParanoidiQ5EA61.
KOiK00933.
OMAiAETQQEM.
OrthoDBiEOG7XM2XW.
TreeFamiTF314214.

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view]
SUPFAMiSSF48034. SSF48034. 1 hit.
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EA61-1 [UniParc]FASTAAdd to Basket

« Hide

MPFSNSHNTL KLRFPAEDEF PDLSGHNNHM AKVLTPELYA ELRAKSTPSG    50
FTVDDVIQTG VDNPGHPYIM TVGCVAGDEE SYDVFKELFD PIIEDRHGGY 100
KPTDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE 150
RRAIEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP 200
LLLASGMARD WPDARGIWHN DNKTFLVWIN EEDHLRVISM QKGGNMKEVF 250
TRFCNGLTQI ETLFKSKNYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP 300
HLGKHEKFPE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV 350
QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K 381
Length:381
Mass (Da):42,719
Last modified:March 15, 2005 - v1
Checksum:iECBA70EF44052A22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020708 mRNA. Translation: AAX08725.1.
BC102333 mRNA. Translation: AAI02334.1.
RefSeqiNP_001015613.1. NM_001015613.1.
XP_003583821.1. XM_003583773.2.
UniGeneiBt.88935.

Genome annotation databases

EnsembliENSBTAT00000050490; ENSBTAP00000047181; ENSBTAG00000035998.
GeneIDi100851864.
516210.
KEGGibta:100851864.
bta:516210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020708 mRNA. Translation: AAX08725.1 .
BC102333 mRNA. Translation: AAI02334.1 .
RefSeqi NP_001015613.1. NM_001015613.1.
XP_003583821.1. XM_003583773.2.
UniGenei Bt.88935.

3D structure databases

ProteinModelPortali Q5EA61.
SMRi Q5EA61. Positions 2-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000004079.

Proteomic databases

PaxDbi Q5EA61.
PRIDEi Q5EA61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000050490 ; ENSBTAP00000047181 ; ENSBTAG00000035998 .
GeneIDi 100851864.
516210.
KEGGi bta:100851864.
bta:516210.

Organism-specific databases

CTDi 1152.

Phylogenomic databases

eggNOGi COG3869.
GeneTreei ENSGT00550000074561.
HOGENOMi HOG000232165.
HOVERGENi HBG001339.
InParanoidi Q5EA61.
KOi K00933.
OMAi AETQQEM.
OrthoDBi EOG7XM2XW.
TreeFami TF314214.

Enzyme and pathway databases

Reactomei REACT_207339. Creatine metabolism.

Miscellaneous databases

NextBioi 20872160.

Family and domain databases

Gene3Di 1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view ]
Pfami PF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
[Graphical view ]
SUPFAMi SSF48034. SSF48034. 1 hit.
PROSITEi PS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiKCRB_BOVIN
AccessioniPrimary (citable) accession number: Q5EA61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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