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Q5EA41

- GALT6_BOVIN

UniProt

Q5EA41 - GALT6_BOVIN

Protein

Polypeptide N-acetylgalactosaminyltransferase 6

Gene

GALNT6

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides By similarity.By similarity

    Catalytic activityi

    UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

    Cofactori

    Manganese.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei217 – 2171SubstrateBy similarity
    Binding sitei246 – 2461SubstrateBy similarity
    Metal bindingi269 – 2691ManganeseBy similarity
    Metal bindingi271 – 2711ManganeseBy similarity
    Binding sitei379 – 3791SubstrateBy similarity
    Metal bindingi407 – 4071ManganeseBy similarity
    Binding sitei410 – 4101SubstrateBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    Lectin, Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiCBM13. Carbohydrate-Binding Module Family 13.
    GT27. Glycosyltransferase Family 27.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polypeptide N-acetylgalactosaminyltransferase 6 (EC:2.4.1.41)
    Alternative name(s):
    Polypeptide GalNAc transferase 6
    Short name:
    GalNAc-T6
    Short name:
    pp-GaNTase 6
    Protein-UDP acetylgalactosaminyltransferase 6
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
    Gene namesi
    Name:GALNT6
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622Polypeptide N-acetylgalactosaminyltransferase 6PRO_0000059113Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi165 ↔ 402PROSITE-ProRule annotation
    Disulfide bondi393 ↔ 474PROSITE-ProRule annotation
    Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi509 ↔ 527PROSITE-ProRule annotation
    Disulfide bondi553 ↔ 566PROSITE-ProRule annotation
    Disulfide bondi597 ↔ 610PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ5EA41.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5EA41.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini29 – 622594LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2820Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini496 – 622127Ricin B-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni176 – 285110Catalytic subdomain AAdd
    BLAST
    Regioni348 – 41063Catalytic subdomain BAdd
    BLAST

    Domaini

    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.By similarity
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.By similarity

    Sequence similaritiesi

    Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239675.
    HOGENOMiHOG000038227.
    HOVERGENiHBG051699.
    InParanoidiQ5EA41.
    KOiK00710.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PfamiPF00535. Glycos_transf_2. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view]
    SMARTiSM00458. RICIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF50370. SSF50370. 1 hit.
    SSF53448. SSF53448. 1 hit.
    PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5EA41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLRRRHMA VRLVMVGSAF VLFLFILQRD VSGREQATEK PWLRSLVSQK    50
    DHVLDLMLGA VHNLRDSMPK FQIRAPEPQQ TLASTNQSCL PGFYTPAELK 100
    PFWERPPQDP NGPGADGKAF QKKEWTPQET QEKEEGYKKH CFNAFASDRI 150
    SLQRALGPDT RPPECVDQKF RRCPPLPATS VIIVFHNEAW STLLRTVYSV 200
    LHTTPAILLK EIILVDDAST DEYLKEPLER YVKQLQVVQV VRQQERKGLI 250
    TARLLGASVA QAEVLTFLDA HCECFHGWLE PLLARIAEDE TVVVSPNIVT 300
    IDLNTFEFSK PVQRGRVQSR GNFDWSLTFG WEVLPAREKQ RRKDETYPIK 350
    SPTFAGGLFS ISKSYFEHIG TYDNQMEIWG GENVEMSFRV WQCGGQLEII 400
    PCSVVGHVFR TKSPHTFPKG INVIARNQVR LAEVWMDGYK EIFYRRNLQA 450
    AQMAREKSFG DISERLQLRE RLNCHNFSWF LDNVYPEMFV PDLKPTFFGA 500
    LKNLGVDHCL DVGENNNGGK PLILYTCHGL GGNQYFEYTT QRDLRHNIAK 550
    QLCLHASAGT LGLRSCHFTG KNSQVPKDEE WEFTQDQLIR NSGSGTCLTS 600
    KDKKPVMATC NPSDPHQHWL FI 622
    Length:622
    Mass (Da):71,138
    Last modified:March 15, 2005 - v1
    Checksum:i05010D38D433A376
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020728 mRNA. Translation: AAX08745.1.
    RefSeqiNP_001015534.1. NM_001015534.1.
    UniGeneiBt.1639.

    Genome annotation databases

    GeneIDi506903.
    KEGGibta:506903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020728 mRNA. Translation: AAX08745.1 .
    RefSeqi NP_001015534.1. NM_001015534.1.
    UniGenei Bt.1639.

    3D structure databases

    ProteinModelPortali Q5EA41.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi CBM13. Carbohydrate-Binding Module Family 13.
    GT27. Glycosyltransferase Family 27.

    Proteomic databases

    PRIDEi Q5EA41.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 506903.
    KEGGi bta:506903.

    Organism-specific databases

    CTDi 11226.

    Phylogenomic databases

    eggNOGi NOG239675.
    HOGENOMi HOG000038227.
    HOVERGENi HBG051699.
    InParanoidi Q5EA41.
    KOi K00710.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 20867793.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    Pfami PF00535. Glycos_transf_2. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view ]
    SMARTi SM00458. RICIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50370. SSF50370. 1 hit.
    SSF53448. SSF53448. 1 hit.
    PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGALT6_BOVIN
    AccessioniPrimary (citable) accession number: Q5EA41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3