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Protein

CXXC-type zinc finger protein 1

Gene

CXXC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 7649PHD-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 21152CXXC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 1
Alternative name(s):
CpG-binding protein
PHD finger and CXXC domain-containing protein 1
Gene namesi
Name:CXXC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Subcellular locationi

  • Nucleus speckle By similarity

  • Note: Associated with euchromatin. During mitosis, excluded from condensed chromosomes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658CXXC-type zinc finger protein 1PRO_0000283720Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei229 – 2291PhosphothreonineBy similarity
Cross-linki252 – 252Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

May be regulated by proteolysis.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5EA28.
PRIDEiQ5EA28.

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A (By similarity). Interacts with ZNF335 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029172.

Structurei

3D structure databases

ProteinModelPortaliQ5EA28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili428 – 47043Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 31962Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi323 – 36139Arg/Lys-rich (basic)Add
BLAST

Domaini

The acidic domain carries the potential to activate transcription.By similarity

Sequence similaritiesi

Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 7649PHD-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 21152CXXC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1632. Eukaryota.
ENOG410YG6P. LUCA.
GeneTreeiENSGT00730000111044.
HOGENOMiHOG000116258.
HOVERGENiHBG051274.
InParanoidiQ5EA28.
KOiK14960.
OMAiCEPCRRT.
OrthoDBiEOG7FXZZ0.
TreeFamiTF320326.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR022056. CpG-bd_C.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF12269. zf-CpG_bind_C. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDASDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF
60 70 80 90 100
HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDSSERDGS
110 120 130 140 150
EPRDEGGGRK RPAPDPDLQR RAGAGTGVGA MLARGSASPH KSSPQPLVAT
160 170 180 190 200
PSQHHQQQQQ QQQIKRSARM CGECEACRRT EDCGHCDFCR DMKKFGGPNK
210 220 230 240 250
IRQKCRLRQC QLRARESYKY FPSSLSPVTP SESLPRPRRP LPTQPQPQPS
260 270 280 290 300
QKLGRLREDE GAVASAAVKE PPEATATPEP LSDEDLPLDS ELYQDFCAGA
310 320 330 340 350
FDDHSLPWMS DTEESQFLDP ALRKRAVKVK HVKRREKKSE KKKDERYKRH
360 370 380 390 400
RQKQKHKDKW KHPERADAKD PASLPQCLGP GCVRAAQPGS KYCSDDCGMK
410 420 430 440 450
LAANRIYEIL PQRIQQWQQS PCIAEEHGKK LLERIRREQQ SARTRLQEME
460 470 480 490 500
RRFHELEAII LRAKQQAVRE DEESNEGDSD DTDLQIFCVS CGHPINPRVA
510 520 530 540 550
LRHMERCYAK YESQTSFGSM YPTRIEGATR LFCDVYNPQS KTYCKRLQVL
560 570 580 590 600
CPEHSRDPKV PADEVCGCPL VRDVFELTGD FCRLPKRQCN RHYCWEKLRR
610 620 630 640 650
AEVDLERVRV WYKLDELFEQ ERNVRTAMTN RAGLLALMLH QTIQHDPLTT

DLRSNAER
Length:658
Mass (Da):75,870
Last modified:March 15, 2005 - v1
Checksum:i14F8C14E2969645B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020741 mRNA. Translation: AAX08758.1.
BC102763 mRNA. Translation: AAI02764.1.
RefSeqiNP_001019688.1. NM_001024517.1.
UniGeneiBt.9994.

Genome annotation databases

EnsembliENSBTAT00000029172; ENSBTAP00000029172; ENSBTAG00000021884.
GeneIDi511446.
KEGGibta:511446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020741 mRNA. Translation: AAX08758.1.
BC102763 mRNA. Translation: AAI02764.1.
RefSeqiNP_001019688.1. NM_001024517.1.
UniGeneiBt.9994.

3D structure databases

ProteinModelPortaliQ5EA28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029172.

Proteomic databases

PaxDbiQ5EA28.
PRIDEiQ5EA28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029172; ENSBTAP00000029172; ENSBTAG00000021884.
GeneIDi511446.
KEGGibta:511446.

Organism-specific databases

CTDi30827.

Phylogenomic databases

eggNOGiKOG1632. Eukaryota.
ENOG410YG6P. LUCA.
GeneTreeiENSGT00730000111044.
HOGENOMiHOG000116258.
HOVERGENiHBG051274.
InParanoidiQ5EA28.
KOiK14960.
OMAiCEPCRRT.
OrthoDBiEOG7FXZZ0.
TreeFamiTF320326.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR022056. CpG-bd_C.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF12269. zf-CpG_bind_C. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCXXC1_BOVIN
AccessioniPrimary (citable) accession number: Q5EA28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 15, 2005
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.