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Protein

CXXC-type zinc finger protein 1

Gene

CXXC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri28 – 76PHD-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri160 – 211CXXC-typePROSITE-ProRule annotationAdd BLAST52

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 1
Alternative name(s):
CpG-binding protein
PHD finger and CXXC domain-containing protein 1
Gene namesi
Name:CXXC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Organism-specific databases

VGNCiVGNC:27859 CXXC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002837201 – 658CXXC-type zinc finger protein 1Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei229PhosphothreonineBy similarity1
Cross-linki252Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

May be regulated by proteolysis.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5EA28
PRIDEiQ5EA28

Expressioni

Gene expression databases

BgeeiENSBTAG00000021884

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A (By similarity). Interacts with ZNF335 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029172

Structurei

3D structure databases

ProteinModelPortaliQ5EA28
SMRiQ5EA28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili428 – 470Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 319Asp/Glu-rich (acidic)Add BLAST62
Compositional biasi323 – 361Arg/Lys-rich (basic)Add BLAST39

Domaini

The acidic domain carries the potential to activate transcription.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri28 – 76PHD-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri160 – 211CXXC-typePROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1632 Eukaryota
ENOG410YG6P LUCA
GeneTreeiENSGT00730000111044
HOGENOMiHOG000116258
HOVERGENiHBG051274
InParanoidiQ5EA28
KOiK14960
OMAiCINITEK
OrthoDBiEOG091G05JX
TreeFamiTF320326

Family and domain databases

InterProiView protein in InterPro
IPR022056 CpG-bd_C
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF12269 zf-CpG_bind_C, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5EA28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDASDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF
60 70 80 90 100
HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDSSERDGS
110 120 130 140 150
EPRDEGGGRK RPAPDPDLQR RAGAGTGVGA MLARGSASPH KSSPQPLVAT
160 170 180 190 200
PSQHHQQQQQ QQQIKRSARM CGECEACRRT EDCGHCDFCR DMKKFGGPNK
210 220 230 240 250
IRQKCRLRQC QLRARESYKY FPSSLSPVTP SESLPRPRRP LPTQPQPQPS
260 270 280 290 300
QKLGRLREDE GAVASAAVKE PPEATATPEP LSDEDLPLDS ELYQDFCAGA
310 320 330 340 350
FDDHSLPWMS DTEESQFLDP ALRKRAVKVK HVKRREKKSE KKKDERYKRH
360 370 380 390 400
RQKQKHKDKW KHPERADAKD PASLPQCLGP GCVRAAQPGS KYCSDDCGMK
410 420 430 440 450
LAANRIYEIL PQRIQQWQQS PCIAEEHGKK LLERIRREQQ SARTRLQEME
460 470 480 490 500
RRFHELEAII LRAKQQAVRE DEESNEGDSD DTDLQIFCVS CGHPINPRVA
510 520 530 540 550
LRHMERCYAK YESQTSFGSM YPTRIEGATR LFCDVYNPQS KTYCKRLQVL
560 570 580 590 600
CPEHSRDPKV PADEVCGCPL VRDVFELTGD FCRLPKRQCN RHYCWEKLRR
610 620 630 640 650
AEVDLERVRV WYKLDELFEQ ERNVRTAMTN RAGLLALMLH QTIQHDPLTT

DLRSNAER
Length:658
Mass (Da):75,870
Last modified:March 15, 2005 - v1
Checksum:i14F8C14E2969645B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020741 mRNA Translation: AAX08758.1
BC102763 mRNA Translation: AAI02764.1
RefSeqiNP_001019688.1, NM_001024517.1
UniGeneiBt.9994

Genome annotation databases

EnsembliENSBTAT00000029172; ENSBTAP00000029172; ENSBTAG00000021884
GeneIDi511446
KEGGibta:511446

Similar proteinsi

Entry informationi

Entry nameiCXXC1_BOVIN
AccessioniPrimary (citable) accession number: Q5EA28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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