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Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

HPD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key enzyme in the degradation of tyrosine.By similarity

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi: L-phenylalanine degradation

This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (PAH)
  2. Tyrosine aminotransferase (TAT)
  3. 4-hydroxyphenylpyruvate dioxygenase (HPD)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Fumarylacetoacetase (FAH)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi183IronBy similarity1
Metal bindingi266IronBy similarity1
Metal bindingi349IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-71182 Phenylalanine and tyrosine catabolism
UniPathwayiUPA00139; UER00362

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
Gene namesi
Name:HPD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:29939 HPD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000883872 – 3934-hydroxyphenylpyruvate dioxygenaseAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei132N6-succinyllysineBy similarity1
Modified residuei211PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5EA20
PeptideAtlasiQ5EA20
PRIDEiQ5EA20

Expressioni

Gene expression databases

BgeeiENSBTAG00000004175

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005469

Structurei

3D structure databases

ProteinModelPortaliQ5EA20
SMRiQ5EA20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 149VOC 1PROSITE-ProRule annotationAdd BLAST132
Domaini180 – 338VOC 2PROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0638 Eukaryota
COG3185 LUCA
GeneTreeiENSGT00530000063474
HOGENOMiHOG000188687
HOVERGENiHBG005987
InParanoidiQ5EA20
KOiK00457
OMAiPTLFFEI
OrthoDBiEOG091G07Y5
TreeFamiTF300622

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR005956 4OHPhenylPyrv_dOase
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PANTHERiPTHR11959 PTHR11959, 1 hit
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
PIRSFiPIRSF009283 HPP_dOase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR01263 4HPPD, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EA20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTYSDKGEK PERGRFLHFH SVTFWVGNAK QAASYYCSKL GFEPLAYKGL
60 70 80 90 100
ETGSREVVSH VVKQGQIVFV FSSALNPWNK EMGDHLVKHG DGVKDIAFEV
110 120 130 140 150
EDCDYIVQKA RERGAKIVRE PWVEQDKLGK VKFAVLQTYG DTTHTLVEKM
160 170 180 190 200
NYTGRFLPGF EAPPFMDPQL SKLPSCSLEI IDHIVGNQPD QEMVSASEWY
210 220 230 240 250
LKNLQFHRFW SVDDTQVHTE YSSLRSVVVA NYEESIKMPI NEPAPGKKKS
260 270 280 290 300
QIQEYVDYNG GAGVQHIALK TKDIITAIRH LRERGVEFLA VPSTYYKQLR
310 320 330 340 350
EKLKMAKIRV KENIDILEEL KILVDYDEKG YLLQIFTKPM QDRPTLFLEV
360 370 380 390
IQRHNHQGFG AGNFNSLFKA FEEEQDLRGN LTDMEPNGVV SGM
Length:393
Mass (Da):44,963
Last modified:January 23, 2007 - v3
Checksum:i03036A1CD0B7BBD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020749 mRNA Translation: AAX08766.1
BC105225 mRNA Translation: AAI05226.1
RefSeqiNP_001015611.1, NM_001015611.1
UniGeneiBt.19922

Genome annotation databases

EnsembliENSBTAT00000005469; ENSBTAP00000005469; ENSBTAG00000004175
GeneIDi516058
KEGGibta:516058

Similar proteinsi

Entry informationi

Entry nameiHPPD_BOVIN
AccessioniPrimary (citable) accession number: Q5EA20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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