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Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

HPD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Key enzyme in the degradation of tyrosine.By similarity

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Pathwayi: L-phenylalanine degradation

This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (PAH)
  2. Tyrosine aminotransferase (TAT)
  3. 4-hydroxyphenylpyruvate dioxygenase (HPD)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Fumarylacetoacetase (FAH)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi183 – 1831IronBy similarity
Metal bindingi266 – 2661IronBy similarity
Metal bindingi349 – 3491IronBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-71182. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00362.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
Gene namesi
Name:HPD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 3933924-hydroxyphenylpyruvate dioxygenasePRO_0000088387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity
Modified residuei132 – 1321N6-succinyllysineBy similarity
Modified residuei211 – 2111PhosphoserineBy similarity
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei250 – 2501PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5EA20.
PeptideAtlasiQ5EA20.
PRIDEiQ5EA20.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004175.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005469.

Structurei

3D structure databases

ProteinModelPortaliQ5EA20.
SMRiQ5EA20. Positions 8-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Phylogenomic databases

eggNOGiKOG0638. Eukaryota.
COG3185. LUCA.
GeneTreeiENSGT00530000063474.
HOGENOMiHOG000188687.
HOVERGENiHBG005987.
InParanoidiQ5EA20.
KOiK00457.
OMAiAKQAAHY.
OrthoDBiEOG091G07Y5.
TreeFamiTF300622.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EA20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTYSDKGEK PERGRFLHFH SVTFWVGNAK QAASYYCSKL GFEPLAYKGL
60 70 80 90 100
ETGSREVVSH VVKQGQIVFV FSSALNPWNK EMGDHLVKHG DGVKDIAFEV
110 120 130 140 150
EDCDYIVQKA RERGAKIVRE PWVEQDKLGK VKFAVLQTYG DTTHTLVEKM
160 170 180 190 200
NYTGRFLPGF EAPPFMDPQL SKLPSCSLEI IDHIVGNQPD QEMVSASEWY
210 220 230 240 250
LKNLQFHRFW SVDDTQVHTE YSSLRSVVVA NYEESIKMPI NEPAPGKKKS
260 270 280 290 300
QIQEYVDYNG GAGVQHIALK TKDIITAIRH LRERGVEFLA VPSTYYKQLR
310 320 330 340 350
EKLKMAKIRV KENIDILEEL KILVDYDEKG YLLQIFTKPM QDRPTLFLEV
360 370 380 390
IQRHNHQGFG AGNFNSLFKA FEEEQDLRGN LTDMEPNGVV SGM
Length:393
Mass (Da):44,963
Last modified:January 23, 2007 - v3
Checksum:i03036A1CD0B7BBD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020749 mRNA. Translation: AAX08766.1.
BC105225 mRNA. Translation: AAI05226.1.
RefSeqiNP_001015611.1. NM_001015611.1.
UniGeneiBt.19922.

Genome annotation databases

EnsembliENSBTAT00000005469; ENSBTAP00000005469; ENSBTAG00000004175.
GeneIDi516058.
KEGGibta:516058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020749 mRNA. Translation: AAX08766.1.
BC105225 mRNA. Translation: AAI05226.1.
RefSeqiNP_001015611.1. NM_001015611.1.
UniGeneiBt.19922.

3D structure databases

ProteinModelPortaliQ5EA20.
SMRiQ5EA20. Positions 8-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005469.

Proteomic databases

PaxDbiQ5EA20.
PeptideAtlasiQ5EA20.
PRIDEiQ5EA20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000005469; ENSBTAP00000005469; ENSBTAG00000004175.
GeneIDi516058.
KEGGibta:516058.

Organism-specific databases

CTDi3242.

Phylogenomic databases

eggNOGiKOG0638. Eukaryota.
COG3185. LUCA.
GeneTreeiENSGT00530000063474.
HOGENOMiHOG000188687.
HOVERGENiHBG005987.
InParanoidiQ5EA20.
KOiK00457.
OMAiAKQAAHY.
OrthoDBiEOG091G07Y5.
TreeFamiTF300622.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00362.
ReactomeiR-BTA-71182. Phenylalanine and tyrosine catabolism.

Gene expression databases

BgeeiENSBTAG00000004175.

Family and domain databases

Gene3Di3.10.180.10. 2 hits.
InterProiIPR005956. 4OHPhenylPyrv_dOase.
IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
[Graphical view]
PANTHERiPTHR11959. PTHR11959. 1 hit.
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFiPIRSF009283. HPP_dOase. 1 hit.
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR01263. 4HPPD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHPPD_BOVIN
AccessioniPrimary (citable) accession number: Q5EA20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.