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Protein
Submitted name:

Peroxisome proliferative activated receptor, alpha isoform 1

Gene

PPARA

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-383280. Nuclear Receptor transcription pathway.
R-BTA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferative activated receptor, alpha isoform 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:PPARAImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSBTAG00000008063.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010606.

Structurei

3D structure databases

ProteinModelPortaliQ5EA13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 175Nuclear receptor DNA-bindingInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation
Contains 1 Nuclear receptor DNA-binding domain.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
KOiK07294.
OMAiYGSGFIT.
OrthoDBiEOG091G05U8.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMVDTESPI GPLSPLEADD LESPLSADFL QEMGTIQEIS QSIGEDSSGS
60 70 80 90 100
FSFTEYQYLG SGPGSDGSVI TDTLSPASSP SSVSYPAVPG SAEESSSIAL
110 120 130 140 150
NIECRICGDK ASGYHYGVHA CEGCKGFFRR TIRLKLVYDK CDRSCKIQKK
160 170 180 190 200
NRNKCQYCRF HKCLSVGMSH NAIRFGRMPR SEKAKLKAEI LTCEHDLEDS
210 220 230 240 250
ETADLKSLAK RIYEAYLKNF NMNKIKARVI LAGKTNNNPP FVIHDMETLC
260 270 280 290 300
MAEKTLVAKL VANGIQNKEA EVRIFHCCQC TSVETVTELT EFAKSIPGFA
310 320 330 340 350
NLDLNDQVTL LKYGVYEAIF AMLSSVMNKD GMLVAYGNGF ITREFLKSLR
360 370 380 390 400
KPFCDIMEPK FDFAMKFNAL ELDDSDISLF VAAIICCGDR PGLLNVGHIE
410 420 430 440 450
KMQEGIVHVL KLHLQNNHPD DVFLFPKLLQ KMADLRQLVT EHAQLVQVIK
460 470
KTESDAALHP LLQEIYRDMY
Length:470
Mass (Da):52,428
Last modified:March 15, 2005 - v1
Checksum:i9F36D23325D247C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02014949 Genomic DNA. No translation available.
DAAA02014950 Genomic DNA. No translation available.
DAAA02014951 Genomic DNA. No translation available.
DAAA02014952 Genomic DNA. No translation available.
BT020756 mRNA. Translation: AAX08773.1.
RefSeqiNP_001029208.1. NM_001034036.1.
XP_005207529.1. XM_005207472.3.
XP_015326928.1. XM_015471442.1.
UniGeneiBt.18241.

Genome annotation databases

EnsembliENSBTAT00000010606; ENSBTAP00000010606; ENSBTAG00000008063.
GeneIDi281992.
KEGGibta:281992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02014949 Genomic DNA. No translation available.
DAAA02014950 Genomic DNA. No translation available.
DAAA02014951 Genomic DNA. No translation available.
DAAA02014952 Genomic DNA. No translation available.
BT020756 mRNA. Translation: AAX08773.1.
RefSeqiNP_001029208.1. NM_001034036.1.
XP_005207529.1. XM_005207472.3.
XP_015326928.1. XM_015471442.1.
UniGeneiBt.18241.

3D structure databases

ProteinModelPortaliQ5EA13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010606; ENSBTAP00000010606; ENSBTAG00000008063.
GeneIDi281992.
KEGGibta:281992.

Organism-specific databases

CTDi5465.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
KOiK07294.
OMAiYGSGFIT.
OrthoDBiEOG091G05U8.
TreeFamiTF316304.

Enzyme and pathway databases

ReactomeiR-BTA-383280. Nuclear Receptor transcription pathway.
R-BTA-400206. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

Gene expression databases

BgeeiENSBTAG00000008063.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003076. 1Cnucl_rcpt_A.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01289. PROXISOMPAAR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5EA13_BOVIN
AccessioniPrimary (citable) accession number: Q5EA13
Entry historyi
Integrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.