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Protein

Tetratricopeptide repeat protein 4

Gene

TTC4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 4
Short name:
TPR repeat protein 4
Gene namesi
Name:TTC4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Tetratricopeptide repeat protein 4PRO_0000328163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei51 – 511PhosphoserineBy similarity
Modified residuei244 – 2441PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5EA11.
PRIDEiQ5EA11.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021186.

Structurei

3D structure databases

ProteinModelPortaliQ5EA11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati79 – 11234TPR 1Add
BLAST
Repeati117 – 15034TPR 2Add
BLAST
Repeati151 – 18434TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the TTC4 family.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0551. Eukaryota.
COG0457. LUCA.
HOGENOMiHOG000230541.
HOVERGENiHBG030742.
InParanoidiQ5EA11.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQQEPGATL DDGMDSFLEK FQSQPYRGGF HESQWEEEFE KIPLFMKNSP
60 70 80 90 100
SEIDPLENPD LACLQSIIFD EERSPEDQAR TYKDEGNDYF KEKDYKKAVI
110 120 130 140 150
SYTEGLKKKC ADPDLNAVLY TNRAAAQYYL GNFRSSLNDV TAARKLKPCH
160 170 180 190 200
LKAIIRGASC HLELKNYVEA VNWCDEGLQI DATEKKLLDL RAKADKLKRT
210 220 230 240 250
EQRDVRKAKL KEKKQQDQNE ALLQAIKARN IRLVAEAAGE DEDSASEGLS
260 270 280 290 300
ELVLYGLSSE NPCGARLGVD DQGRLSWPVL FLYPEYAQSD LVSAFHEDSR
310 320 330 340 350
FIDHLMVMFG ETPSWDLEQK YCPDNLEVYF EDEDRAELYC VPPSSTLLQV
360 370 380
LQHPRYFVKA LTPTFLVCVG SSGFCRNYLR GKKVHQVK
Length:388
Mass (Da):44,373
Last modified:April 8, 2008 - v2
Checksum:i850CC232DA4410BF
GO

Sequence cautioni

The sequence AAX08775.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551Y → H in AAI40529 (Ref. 2) Curated
Sequence conflicti258 – 2581S → G in AAI40529 (Ref. 2) Curated
Sequence conflicti286 – 2861Y → H in AAI40529 (Ref. 2) Curated
Sequence conflicti318 – 3181E → D in AAI40529 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020758 mRNA. Translation: AAX08775.1. Different initiation.
BC140528 mRNA. Translation: AAI40529.1.
RefSeqiNP_001015554.1. NM_001015554.1.
UniGeneiBt.25094.

Genome annotation databases

GeneIDi509047.
KEGGibta:509047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020758 mRNA. Translation: AAX08775.1. Different initiation.
BC140528 mRNA. Translation: AAI40529.1.
RefSeqiNP_001015554.1. NM_001015554.1.
UniGeneiBt.25094.

3D structure databases

ProteinModelPortaliQ5EA11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021186.

Proteomic databases

PaxDbiQ5EA11.
PRIDEiQ5EA11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi509047.
KEGGibta:509047.

Organism-specific databases

CTDi7268.

Phylogenomic databases

eggNOGiKOG0551. Eukaryota.
COG0457. LUCA.
HOGENOMiHOG000230541.
HOVERGENiHBG030742.
InParanoidiQ5EA11.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiTTC4_BOVIN
AccessioniPrimary (citable) accession number: Q5EA11
Secondary accession number(s): A5D7E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.