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Protein

GPI mannosyltransferase 1

Gene

PIGM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT50. Glycosyltransferase Family 50.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 1 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase I
Short name:
GPI-MT-I
Phosphatidylinositol-glycan biosynthesis class M protein
Short name:
PIG-M
Gene namesi
Name:PIGM
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence analysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Topological domaini39 – 8951LumenalSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Topological domaini111 – 225115CytoplasmicSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 28741LumenalSequence analysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence analysisAdd
BLAST
Topological domaini309 – 32921CytoplasmicSequence analysisAdd
BLAST
Transmembranei330 – 35021HelicalSequence analysisAdd
BLAST
Topological domaini351 – 3577LumenalSequence analysis
Transmembranei358 – 37821HelicalSequence analysisAdd
BLAST
Topological domaini379 – 3846CytoplasmicSequence analysis
Transmembranei385 – 40521HelicalSequence analysisAdd
BLAST
Topological domaini406 – 42318LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423GPI mannosyltransferase 1PRO_0000246212Add
BLAST

Proteomic databases

PaxDbiQ5EA10.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003140.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3893. Eukaryota.
ENOG410XRDY. LUCA.
HOGENOMiHOG000186884.
HOVERGENiHBG082137.
InParanoidiQ5EA10.
KOiK05284.

Family and domain databases

InterProiIPR007704. Mannosyltransferase_DXD.
[Graphical view]
PANTHERiPTHR12886. PTHR12886. 1 hit.
PfamiPF05007. Mannosyl_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EA10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPTTHWGDK FLNLRVPPAG VFVVAFFARV ALIFYGVFQD RTLLVRYTDI
60 70 80 90 100
DYQVFTDAAR FVTEGHSPYL RATYRYTPLL AWLLTPNIYL NELFGKFLFI
110 120 130 140 150
SFDLFTAFLL YRLLLLKGLG RRQACGYCVF WLLNPLPMAV SSRGNADSIV
160 170 180 190 200
ASLVLMTLYL IEKRLVACAA VSYGFAVHLK MYPVTYILPI ALHLLPERDS
210 220 230 240 250
DEGLRQSRYS FQVRLYEFLK RLCHRAVLLF VAVAGLTFFA LSFGFYYRYG
260 270 280 290 300
WEFLEHAYLY HLTRRDIRHN FSPYFYMLYL TAESKWSFSL GIAAFLPQFI
310 320 330 340 350
LLSAVSFAYY RDLVFCCFLH TSIFVTFNKV CTSQYFLWYL CLLPLVMPLV
360 370 380 390 400
RIPWRRAVVL LMLWFIGQAL WLAPAYVLEF QGKNTFLFIW LAGLFFLLIN
410 420
CSILIQIISH YKEEPLTDRT KYD
Length:423
Mass (Da):49,553
Last modified:March 15, 2005 - v1
Checksum:i875B1D67174DB788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020759 mRNA. Translation: AAX08776.1.
RefSeqiNP_001015563.1. NM_001015563.1.
UniGeneiBt.31945.

Genome annotation databases

GeneIDi509680.
KEGGibta:509680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020759 mRNA. Translation: AAX08776.1.
RefSeqiNP_001015563.1. NM_001015563.1.
UniGeneiBt.31945.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003140.

Protein family/group databases

CAZyiGT50. Glycosyltransferase Family 50.

Proteomic databases

PaxDbiQ5EA10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi509680.
KEGGibta:509680.

Organism-specific databases

CTDi93183.

Phylogenomic databases

eggNOGiKOG3893. Eukaryota.
ENOG410XRDY. LUCA.
HOGENOMiHOG000186884.
HOVERGENiHBG082137.
InParanoidiQ5EA10.
KOiK05284.

Enzyme and pathway databases

UniPathwayiUPA00196.

Family and domain databases

InterProiIPR007704. Mannosyltransferase_DXD.
[Graphical view]
PANTHERiPTHR12886. PTHR12886. 1 hit.
PfamiPF05007. Mannosyl_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGM_BOVIN
AccessioniPrimary (citable) accession number: Q5EA10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.