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Q5EA01

- B3GN1_BOVIN

UniProt

Q5EA01 - B3GN1_BOVIN

Protein

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase

Gene

B3GNT1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
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    Functioni

    Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. Involved in alpha-dystroglycan (DAG1) glycosylation By similarity.By similarity

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.

    Pathwayi

    GO - Molecular functioni

    1. N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. axon guidance Source: Ensembl
    2. poly-N-acetyllactosamine biosynthetic process Source: Ensembl
    3. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_211440. Keratan sulfate biosynthesis.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT49. Glycosyltransferase Family 49.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC:2.4.1.149)
    Alternative name(s):
    I-beta-1,3-N-acetylglucosaminyltransferase
    Short name:
    iGnT
    Poly-N-acetyllactosamine extension enzyme
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
    Gene namesi
    Name:B3GNT1
    Synonyms:B3GNT6
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 29

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferasePRO_0000080554Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88CytoplasmicSequence Analysis
    Topological domaini37 – 415379LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 3628Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 49 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325995.
    GeneTreeiENSGT00530000063165.
    HOGENOMiHOG000064521.
    HOVERGENiHBG080885.
    InParanoidiQ5EA01.
    KOiK00741.
    OMAiMPMSKTE.
    OrthoDBiEOG7PVWPF.
    TreeFamiTF319168.

    Family and domain databases

    InterProiIPR026603. N-AclacN_B-1_3-N-AclacNTrfase.
    [Graphical view]
    PANTHERiPTHR12270:SF20. PTHR12270:SF20. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5EA01-1 [UniParc]FASTAAdd to Basket

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    MQMSYAIRCA FYQLLLAALM LVAMLQLLYL SLLSGLHGQE EQDQYFEFFP    50
    PSPRSVDQVK AQLRTALASG GVLDASGDYR VYRGLLKTTM DPNDVILATH 100
    ASVDNLLHLS GLLERWEGPL SVSVFAATKE EAQLATVLTY ALSSHCPDMR 150
    ARVAMHLVCP SRYEAAVPDP REPGEFALLR SCQEVFDKLA RVAQPGVNYA 200
    LGTNVSYPNN LLRNLAREGA NYALVIDVDM VPSEGLWRSL REMLDQSKQW 250
    AGTALVVPAF EIRRARRMPM NKNELLQLYQ VGEVRPFYYG LCTPCQAPTN 300
    YSRWVNLPEE TLLRPAYVVP WQDPWEPFYV AGGKVPTFDE RFRQYGFNRI 350
    SQACELHVAG FDFEVLNEGF LVHKGFKEVL KFHPQKEAEN QHNKILYRQF 400
    KQELKAKYPD SPRHC 415
    Length:415
    Mass (Da):47,231
    Last modified:May 30, 2006 - v2
    Checksum:i1B0FB74C8F8266C2
    GO

    Sequence cautioni

    The sequence AAX46482.1 differs from that shown. Reason: Frameshift at position 387.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti178 – 1781L → P in AAI05207. (PubMed:16305752)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020768 mRNA. Translation: AAX08785.1.
    BT021635 mRNA. Translation: AAX46482.1. Frameshift.
    BC105206 mRNA. Translation: AAI05207.1.
    RefSeqiNP_001029980.1. NM_001034808.1.
    UniGeneiBt.65469.

    Genome annotation databases

    EnsembliENSBTAT00000030023; ENSBTAP00000030011; ENSBTAG00000022238.
    GeneIDi618055.
    KEGGibta:618055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020768 mRNA. Translation: AAX08785.1 .
    BT021635 mRNA. Translation: AAX46482.1 . Frameshift.
    BC105206 mRNA. Translation: AAI05207.1 .
    RefSeqi NP_001029980.1. NM_001034808.1.
    UniGenei Bt.65469.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT49. Glycosyltransferase Family 49.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000030023 ; ENSBTAP00000030011 ; ENSBTAG00000022238 .
    GeneIDi 618055.
    KEGGi bta:618055.

    Organism-specific databases

    CTDi 11041.

    Phylogenomic databases

    eggNOGi NOG325995.
    GeneTreei ENSGT00530000063165.
    HOGENOMi HOG000064521.
    HOVERGENi HBG080885.
    InParanoidi Q5EA01.
    KOi K00741.
    OMAi MPMSKTE.
    OrthoDBi EOG7PVWPF.
    TreeFami TF319168.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_211440. Keratan sulfate biosynthesis.

    Miscellaneous databases

    NextBioi 20900975.

    Family and domain databases

    InterProi IPR026603. N-AclacN_B-1_3-N-AclacNTrfase.
    [Graphical view ]
    PANTHERi PTHR12270:SF20. PTHR12270:SF20. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Kidney.

    Entry informationi

    Entry nameiB3GN1_BOVIN
    AccessioniPrimary (citable) accession number: Q5EA01
    Secondary accession number(s): Q3MHK2, Q58DG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3