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Q5EA01

- B3GN1_BOVIN

UniProt

Q5EA01 - B3GN1_BOVIN

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Protein
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
Gene
B3GNT1, B3GNT6
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. Involved in alpha-dystroglycan (DAG1) glycosylation By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.

Pathwayi

GO - Molecular functioni

  1. N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. poly-N-acetyllactosamine biosynthetic process Source: Ensembl
  3. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_211440. Keratan sulfate biosynthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT49. Glycosyltransferase Family 49.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC:2.4.1.149)
Alternative name(s):
I-beta-1,3-N-acetylglucosaminyltransferase
Short name:
iGnT
Poly-N-acetyllactosamine extension enzyme
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
Gene namesi
Name:B3GNT1
Synonyms:B3GNT6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 29

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Cytoplasmic Reviewed prediction
Transmembranei9 – 3628Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini37 – 415379Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
PRO_0000080554Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi204 – 2041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325995.
GeneTreeiENSGT00530000063165.
HOGENOMiHOG000064521.
HOVERGENiHBG080885.
InParanoidiQ5EA01.
KOiK00741.
OMAiMPMSKTE.
OrthoDBiEOG7PVWPF.
TreeFamiTF319168.

Family and domain databases

InterProiIPR026603. N-AclacN_B-1_3-N-AclacNTrfase.
[Graphical view]
PANTHERiPTHR12270:SF20. PTHR12270:SF20. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5EA01-1 [UniParc]FASTAAdd to Basket

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MQMSYAIRCA FYQLLLAALM LVAMLQLLYL SLLSGLHGQE EQDQYFEFFP    50
PSPRSVDQVK AQLRTALASG GVLDASGDYR VYRGLLKTTM DPNDVILATH 100
ASVDNLLHLS GLLERWEGPL SVSVFAATKE EAQLATVLTY ALSSHCPDMR 150
ARVAMHLVCP SRYEAAVPDP REPGEFALLR SCQEVFDKLA RVAQPGVNYA 200
LGTNVSYPNN LLRNLAREGA NYALVIDVDM VPSEGLWRSL REMLDQSKQW 250
AGTALVVPAF EIRRARRMPM NKNELLQLYQ VGEVRPFYYG LCTPCQAPTN 300
YSRWVNLPEE TLLRPAYVVP WQDPWEPFYV AGGKVPTFDE RFRQYGFNRI 350
SQACELHVAG FDFEVLNEGF LVHKGFKEVL KFHPQKEAEN QHNKILYRQF 400
KQELKAKYPD SPRHC 415
Length:415
Mass (Da):47,231
Last modified:May 30, 2006 - v2
Checksum:i1B0FB74C8F8266C2
GO

Sequence cautioni

The sequence AAX46482.1 differs from that shown. Reason: Frameshift at position 387.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781L → P in AAI05207. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020768 mRNA. Translation: AAX08785.1.
BT021635 mRNA. Translation: AAX46482.1. Frameshift.
BC105206 mRNA. Translation: AAI05207.1.
RefSeqiNP_001029980.1. NM_001034808.1.
UniGeneiBt.65469.

Genome annotation databases

EnsembliENSBTAT00000030023; ENSBTAP00000030011; ENSBTAG00000022238.
GeneIDi618055.
KEGGibta:618055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020768 mRNA. Translation: AAX08785.1 .
BT021635 mRNA. Translation: AAX46482.1 . Frameshift.
BC105206 mRNA. Translation: AAI05207.1 .
RefSeqi NP_001029980.1. NM_001034808.1.
UniGenei Bt.65469.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT49. Glycosyltransferase Family 49.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000030023 ; ENSBTAP00000030011 ; ENSBTAG00000022238 .
GeneIDi 618055.
KEGGi bta:618055.

Organism-specific databases

CTDi 11041.

Phylogenomic databases

eggNOGi NOG325995.
GeneTreei ENSGT00530000063165.
HOGENOMi HOG000064521.
HOVERGENi HBG080885.
InParanoidi Q5EA01.
KOi K00741.
OMAi MPMSKTE.
OrthoDBi EOG7PVWPF.
TreeFami TF319168.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_211440. Keratan sulfate biosynthesis.

Miscellaneous databases

NextBioi 20900975.

Family and domain databases

InterProi IPR026603. N-AclacN_B-1_3-N-AclacNTrfase.
[Graphical view ]
PANTHERi PTHR12270:SF20. PTHR12270:SF20. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Kidney.

Entry informationi

Entry nameiB3GN1_BOVIN
AccessioniPrimary (citable) accession number: Q5EA01
Secondary accession number(s): Q3MHK2, Q58DG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 30, 2006
Last modified: September 3, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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