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Protein

Gap junction beta-6 protein

Gene

GJB6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

Keywordsi

Biological processHearing

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-6 protein
Gene namesi
Name:GJB6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 131CytoplasmicSequence analysisAdd BLAST33
Transmembranei132 – 154HelicalSequence analysisAdd BLAST23
Topological domaini155 – 192ExtracellularSequence analysisAdd BLAST38
Transmembranei193 – 215HelicalSequence analysisAdd BLAST23
Topological domaini216 – 261CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002448781 – 261Gap junction beta-6 proteinAdd BLAST261

Proteomic databases

PaxDbiQ5E9Z5.
PRIDEiQ5E9Z5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000038662.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000052852.

Structurei

3D structure databases

SMRiQ5E9Z5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8. Eukaryota.
ENOG410Y7VN. LUCA.
GeneTreeiENSGT00900000140773.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ5E9Z5.
KOiK07625.
OMAiQTQRNHP.
OrthoDBiEOG091G0FKH.
TreeFamiTF329606.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5E9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGTLHTFV GGVNKHSTSI GKVWVTVLFV FRVMILVVAA QEVWGDEQED
60 70 80 90 100
FVCNTLQPGC RNVCYDHFFP VSHIRLWALQ LIFVSTPALL VAMHVAYYRH
110 120 130 140 150
EAARRFRRGE TRSEFKDLED IKRQKVRIEG SLWWTYTSSI FFRIVFEAAF
160 170 180 190 200
MYVFYFLYNG YHLPWVLKCG IQPCPNLVDC FISRPTEKTV FTIFMISASV
210 220 230 240 250
ICMLLNVAEL CYLLLKVCFR RSKRAQTQKA PPNHALKESK QNEMNELISE
260
GGQNAITGFP S
Length:261
Mass (Da):30,229
Last modified:March 15, 2005 - v1
Checksum:i3FAC8D34508348AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020774 mRNA. Translation: AAX08791.1.
BC123433 mRNA. Translation: AAI23434.1.
RefSeqiNP_001015546.1. NM_001015546.1.
NP_001153649.1. NM_001160177.1.
XP_005213824.1. XM_005213767.3.
XP_005213825.1. XM_005213768.3.
XP_005213826.1. XM_005213769.3.
UniGeneiBt.35935.

Genome annotation databases

EnsembliENSBTAT00000052057; ENSBTAP00000052852; ENSBTAG00000038662.
GeneIDi508454.
KEGGibta:508454.

Similar proteinsi

Entry informationi

Entry nameiCXB6_BOVIN
AccessioniPrimary (citable) accession number: Q5E9Z5
Secondary accession number(s): Q08E41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 15, 2005
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families