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Protein

Nucleoside diphosphate kinase 7

Gene

NME7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991ATPBy similarity
Binding sitei145 – 1451ATPBy similarity
Binding sitei193 – 1931ATPBy similarity
Binding sitei203 – 2031ATPBy similarity
Active sitei206 – 2061Pros-phosphohistidine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase 7 (EC:2.7.4.6)
Short name:
NDK 7
Short name:
NDP kinase 7
Gene namesi
Name:NME7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Nucleoside diphosphate kinase 7PRO_0000245168Add
BLAST

Proteomic databases

PaxDbiQ5E9Y9.
PRIDEiQ5E9Y9.

Expressioni

Gene expression databases

ExpressionAtlasiQ5E9Y9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044149.

Structurei

3D structure databases

ProteinModelPortaliQ5E9Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9189DM10PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NDK family.Curated
Contains 1 DM10 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224566.
HOVERGENiHBG006457.
InParanoidiQ5E9Y9.
KOiK00940.
OMAiMEIQQNN.
OrthoDBiEOG7HF1JJ.
TreeFamiTF106374.

Family and domain databases

InterProiIPR011410. NDK7.
IPR001564. Nucleoside_diP_kinase.
IPR006602. Uncharacterised_DM10.
[Graphical view]
PfamiPF00334. NDK. 2 hits.
[Graphical view]
PIRSFiPIRSF036503. NDK7. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00676. DM10. 1 hit.
SM00562. NDK. 2 hits.
[Graphical view]
PROSITEiPS51336. DM10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E9Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSERFVFI AEWFDPNASL FRRYELLFYP GDGSVEMHDV KNHRTFLKRT
60 70 80 90 100
KYEDLHLEDL FIGNKVNIFS RQLVLLDYGD QYTARQLGSK KEKTLALIKP
110 120 130 140 150
DAVSKAGEII EIINKAGFTL TKLKMMTLSR KEATDFHIDH QSRPFLNELI
160 170 180 190 200
QFITSGPIIA MEILRDDAVC EWKRLLGPAN SGLARTDAPE SIRALFGTDG
210 220 230 240 250
IKNAAHGPDS FACAAREMEL FFPSSGVCGP ANTAKFTNCT TCCIVKPHAV
260 270 280 290 300
SEGLLGKILM TIRDAGFEIS AMQMFNMDRI NVEEFYEVYK GVVSEYNEMV
310 320 330 340 350
TEMYSGPCVA MEIQQTNPTM TFREFCGPAD PEIARHLRPG TLRAIFGKTK
360 370
IQNAVHCTDL PEDGLLEVQY FFKILDN
Length:377
Mass (Da):42,599
Last modified:March 15, 2005 - v1
Checksum:i95E8E0AD5D5047EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020780 mRNA. Translation: AAX08797.1.
BC109996 mRNA. Translation: AAI09997.1.
RefSeqiNP_001015656.1. NM_001015656.1.
UniGeneiBt.6993.

Genome annotation databases

EnsembliENSBTAT00000046902; ENSBTAP00000044149; ENSBTAG00000002689.
GeneIDi534611.
KEGGibta:534611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020780 mRNA. Translation: AAX08797.1.
BC109996 mRNA. Translation: AAI09997.1.
RefSeqiNP_001015656.1. NM_001015656.1.
UniGeneiBt.6993.

3D structure databases

ProteinModelPortaliQ5E9Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044149.

Proteomic databases

PaxDbiQ5E9Y9.
PRIDEiQ5E9Y9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000046902; ENSBTAP00000044149; ENSBTAG00000002689.
GeneIDi534611.
KEGGibta:534611.

Organism-specific databases

CTDi29922.

Phylogenomic databases

eggNOGiKOG0888. Eukaryota.
COG0105. LUCA.
GeneTreeiENSGT00760000119146.
HOGENOMiHOG000224566.
HOVERGENiHBG006457.
InParanoidiQ5E9Y9.
KOiK00940.
OMAiMEIQQNN.
OrthoDBiEOG7HF1JJ.
TreeFamiTF106374.

Miscellaneous databases

NextBioi20876468.

Gene expression databases

ExpressionAtlasiQ5E9Y9. baseline and differential.

Family and domain databases

InterProiIPR011410. NDK7.
IPR001564. Nucleoside_diP_kinase.
IPR006602. Uncharacterised_DM10.
[Graphical view]
PfamiPF00334. NDK. 2 hits.
[Graphical view]
PIRSFiPIRSF036503. NDK7. 1 hit.
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00676. DM10. 1 hit.
SM00562. NDK. 2 hits.
[Graphical view]
PROSITEiPS51336. DM10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiNDK7_BOVIN
AccessioniPrimary (citable) accession number: Q5E9Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 15, 2005
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.