Reviewed, UniProtKB/Swiss-Prot Q5E9Y9 (NDK7_BOVIN)

Names and origin

Protein names

Recommended name:
    Nucleoside diphosphate kinase 7
      Short name=NDP kinase 7
      Short name=NDK 7
    EC=2.7.4.6

Gene names

Name:

NME7

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate By similarity.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family. Contains 1 DM10 domain.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Nucleoside diphosphate kinase 7		PRO_0000245168
Regions
	Domain	3 – 91	89	DM10
Sites
	Active site	206	1	Pros-phosphohistidine intermediate By similarity
	Binding site	99	1	ATP By similarity
	Binding site	145	1	ATP By similarity
	Binding site	193	1	ATP By similarity
	Binding site	203	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5E9Y9-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 95E8E0AD5D5047EA	FASTA	377	42,599
	10 20 30 40 50 60 MNHSERFVFI AEWFDPNASL FRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYEDLHLEDL 70 80 90 100 110 120 FIGNKVNIFS RQLVLLDYGD QYTARQLGSK KEKTLALIKP DAVSKAGEII EIINKAGFTL 130 140 150 160 170 180 TKLKMMTLSR KEATDFHIDH QSRPFLNELI QFITSGPIIA MEILRDDAVC EWKRLLGPAN 190 200 210 220 230 240 SGLARTDAPE SIRALFGTDG IKNAAHGPDS FACAAREMEL FFPSSGVCGP ANTAKFTNCT 250 260 270 280 290 300 TCCIVKPHAV SEGLLGKILM TIRDAGFEIS AMQMFNMDRI NVEEFYEVYK GVVSEYNEMV 310 320 330 340 350 360 TEMYSGPCVA MEIQQTNPTM TFREFCGPAD PEIARHLRPG TLRAIFGKTK IQNAVHCTDL 370 PEDGLLEVQY FFKILDN

References

[1]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT020780 mRNA. Translation: AAX08797.1. BC109996 mRNA. Translation: AAI09997.1.
IPI	IPI00701434.
RefSeq	NP_001015656.1.
UniGene	Bt.6993
3D structure databases
SMR	Q5E9Y9. Positions 8-89, 86-228, 240-373.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5E9Y9.
Genome annotation databases
Ensembl	ENSBTAT00000046902; ENSBTAP00000044149; ENSBTAG00000002689; Bos taurus. [Genome view]
GeneID	534611.
KEGG	bta:534611.
Organism-specific databases
CTD	534611.
Phylogenomic databases
HOVERGEN	Q5E9Y9.
InParanoid	Q5E9Y9.
OMA	PHAISEG.
OrthoDB	EOG9962B7.
Enzyme and pathway databases
BRENDA	2.7.4.6. 251.
Family and domain databases
InterPro	IPR006602. DUF_DM10. IPR011410. NDK7. IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 2 hits.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 2 hits. [Graphical view]
PIRSF	PIRSF036503. NDK7. 1 hit.
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00676. DM10. 1 hit. SM00562. NDK. 2 hits. [Graphical view]
PROSITE	PS51336. DM10. 1 hit. PS00469. NDP_KINASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDK7_BOVIN

Accession

Primary (citable) accession number: Q5E9Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	March 15, 2005
Last modified:	January 19, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)