Reviewed,
UniProtKB/Swiss-Prot Q5E9Y0 (CDK2_BOVIN)
Last modified
February 9, 2010.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell division protein kinase 2 EC=2.7.11.22 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 298 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2 By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Enzyme regulation | Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it By similarity. |
| Subunit structure | Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1. Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1 By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 298 | 298 | Cell division protein kinase 2 | PRO_0000085767 | |||||
Regions | |||||||||
| Domain | 4 – 286 | 283 | Protein kinase | ||||||
| Nucleotide binding | 10 – 18 | 9 | ATP By similarity | ||||||
| Nucleotide binding | 81 – 83 | 3 | ATP By similarity | ||||||
| Nucleotide binding | 129 – 132 | 4 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 127 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 33 | 1 | ATP By similarity | ||||||
| Binding site | 86 | 1 | ATP By similarity | ||||||
| Binding site | 145 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 6 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 14 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 15 | 1 | Phosphotyrosine; by WEE1 By similarity | ||||||
| Modified residue | 19 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 46 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 158 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 159 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 160 | 1 | Phosphothreonine; by CAK and CCRK By similarity | ||||||
Sequences
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References
| [1] | "Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BT020790 mRNA. Translation: AAX08807.1. BC150026 mRNA. Translation: AAI50027.1. |
| IPI | IPI00712735. |
| RefSeq | NP_001014934.1. |
| UniGene | Bt.21444 |
3D structure databases | |
| SMR | Q5E9Y0. Positions 1-298. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5E9Y0. |
Genome annotation databases | |
| Ensembl | ENSBTAT00000005252; ENSBTAP00000005252; ENSBTAG00000004021; Bos taurus. [Genome view] |
| GeneID | 519217. |
| KEGG | bta:519217. |
Organism-specific databases | |
| CTD | 519217. |
Phylogenomic databases | |
| eggNOG | maNOG16767. |
| HOVERGEN | Q5E9Y0. |
| InParanoid | Q5E9Y0. |
| OMA | LDLKKYM. |
| OrthoDB | EOG95QKZV. |
| PhylomeDB | Q5E9Y0. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.22. 251. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDK2_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q5E9Y0 Secondary accession number(s): A6QQX1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


