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Protein

Protein Wnt-16

Gene

WNT16

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-16
Gene namesi
Name:WNT16
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000024806830 – 362Protein Wnt-16Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi81 ↔ 92By similarity
Disulfide bondi136 ↔ 144By similarity
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 165By similarity
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi218 ↔ 232By similarity
Disulfide bondi220 ↔ 227By similarity
Lipidationi224O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi307 ↔ 322By similarity
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi337 ↔ 352By similarity
Disulfide bondi339 ↔ 349By similarity
Disulfide bondi344 ↔ 345By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ5E9U6.
PRIDEiQ5E9U6.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003825.

Structurei

3D structure databases

SMRiQ5E9U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ5E9U6.
KOiK01558.
TreeFamiTF105310.

Family and domain databases

InterProiView protein in InterPro
IPR005817. Wnt.
IPR013304. Wnt16.
IPR018161. Wnt_CS.
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiView protein in Pfam
PF00110. wnt. 1 hit.
PRINTSiPR01895. WNT16PROTEIN.
PR01349. WNTPROTEIN.
SMARTiView protein in SMART
SM00097. WNT1. 1 hit.
PROSITEiView protein in PROSITE
PS00246. WNT1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAALLGLS RLCALWAAVL ALFPCGAQGN WMWLGIASFG VPEKLGCANL
60 70 80 90 100
PLNSRQKELC KRKPYLLPSI REGARLGIQE CRSQFRHERW NCLVAAASAP
110 120 130 140 150
GTSPLFGYEL SSGTKETAFI YAVMAAGLVH SVTRSCSAGN MTECSCDTTL
160 170 180 190 200
QNGGSSSEGW HWGGCSDDVQ YGMWFSRKFL DFPIKNTTAK ESKVLLAMNL
210 220 230 240 250
HNNEAGRQAV AKLMSLDCRC HGVSGSCAVK TCWKTMSSFE KIGHLLKDKY
260 270 280 290 300
ENSVQISDKI KRKMHRREKD QRKIPIRKDD LLYVNKSPNY CVEDKKLGIP
310 320 330 340 350
GTQGRECNRT SEGADGCNLL CCGRGYNTHV VRHVERCECK FIWCCYVRCR
360
RCESMTDVHT CK
Length:362
Mass (Da):40,440
Last modified:March 15, 2005 - v1
Checksum:i24CD4FF27C664062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156S → A in AAI19881 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020824 mRNA. Translation: AAX08841.1.
BC119880 mRNA. Translation: AAI19881.1.
RefSeqiNP_001014949.1. NM_001014949.1.
UniGeneiBt.37171.

Genome annotation databases

GeneIDi538627.
KEGGibta:538627.

Similar proteinsi

Entry informationi

Entry nameiWNT16_BOVIN
AccessioniPrimary (citable) accession number: Q5E9U6
Secondary accession number(s): Q0VD20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 15, 2005
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families