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Protein

tRNA wybutosine-synthesizing protein 3 homolog

Gene

TYW3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).

Pathwayi: wybutosine-tRNA(Phe) biosynthesis

This protein is involved in the pathway wybutosine-tRNA(Phe) biosynthesis, which is part of tRNA modification.
View all proteins of this organism that are known to be involved in the pathway wybutosine-tRNA(Phe) biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00375

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA wybutosine-synthesizing protein 3 homolog (EC:2.1.1.282)
Short name:
tRNA-yW-synthesizing protein 3
Alternative name(s):
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
Gene namesi
Name:TYW3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:36554 TYW3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818411 – 258tRNA wybutosine-synthesizing protein 3 homologAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5E9U4
PRIDEiQ5E9U4

Expressioni

Gene expression databases

BgeeiENSBTAG00000005196

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006849

Structurei

3D structure databases

ProteinModelPortaliQ5E9U4
SMRiQ5E9U4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TYW3 family.Curated

Phylogenomic databases

eggNOGiKOG1228 Eukaryota
COG1590 LUCA
GeneTreeiENSGT00390000018149
HOGENOMiHOG000007205
HOVERGENiHBG106708
InParanoidiQ5E9U4
KOiK15450
OMAiGKWHHYA
OrthoDBiEOG091G0KHY
TreeFamiTF329327

Family and domain databases

Gene3Di3.30.1960.10, 1 hit
InterProiView protein in InterPro
IPR003827 tRNA_yW-synthesising
IPR036602 tRNA_yW-synthesising-like_sf
PfamiView protein in Pfam
PF02676 TYW3, 1 hit
SUPFAMiSSF111278 SSF111278, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E9U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSAEFKRW KAQCLSKADL SRKGSVDEDV LEIVQLLNGQ EQFFTTSSCA
60 70 80 90 100
GRIILLDRSV NGSEVQKQNC CWLLVTHKAC VKDDVIVALQ KAKGDAILKF
110 120 130 140 150
EPLVLHVQCR QLQDAQILHS VAIDSGFRNS GITVGKRGKT MLAVRSTHGL
160 170 180 190 200
EVPLSHQGKL MVTEEYINFL LKIANQKMEE NKKRIERFYH CLQHALEKET
210 220 230 240 250
VSTTSQPKEK VNTSYIRKKK RNPGKARGKR VNEEHDKELE NNDHDDPGIS

DTIFPEDY
Length:258
Mass (Da):29,303
Last modified:March 15, 2005 - v1
Checksum:iB0ABAB3BB79E095C
GO

Sequence cautioni

The sequence AAI14026 differs from that shown. Reason: Frameshift at position 221.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170L → Q in AAI14026 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020826 mRNA Translation: AAX08843.1
BC114025 mRNA Translation: AAI14026.1 Frameshift.
RefSeqiNP_001015620.1, NM_001015620.1
UniGeneiBt.16963

Genome annotation databases

EnsembliENSBTAT00000006849; ENSBTAP00000006849; ENSBTAG00000005196
GeneIDi519731
KEGGibta:519731

Similar proteinsi

Entry informationi

Entry nameiTYW3_BOVIN
AccessioniPrimary (citable) accession number: Q5E9U4
Secondary accession number(s): Q24K18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health