Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 35A

Gene

TMEM35A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 35A
Gene namesi
Name:TMEM35A
Synonyms:TMEM35
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei115 – 132HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716061 – 177Transmembrane protein 35AAdd BLAST177

Proteomic databases

PaxDbiQ5E9T5.
PRIDEiQ5E9T5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021252.

Interactioni

Subunit structurei

May interact with NGFR.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028319.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 54Interaction with NGFRBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the DoxX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ5E9T5.
OMAiSKWYRRV.
OrthoDBiEOG091G0TZU.
TreeFamiTF300206.

Family and domain databases

InterProiView protein in InterPro
IPR032808. DoxX.
IPR029693. TMEM35A.
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiView protein in Pfam
PF13564. DoxX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5E9T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRTVTVV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKSSPPGNA
160 170
GSDGNAGNTE EQPSLYEKAP QGKMKLS
Length:177
Mass (Da):19,307
Last modified:March 15, 2005 - v1
Checksum:i539355781EB9D52F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5R → I in AAX08677 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020660 mRNA. Translation: AAX08677.1.
BT020835 mRNA. Translation: AAX08852.1.
BC122649 mRNA. Translation: AAI22650.1.
RefSeqiNP_001014940.1. NM_001014940.1.
UniGeneiBt.22696.

Genome annotation databases

EnsembliENSBTAT00000028319; ENSBTAP00000028319; ENSBTAG00000021252.
GeneIDi533337.
KEGGibta:533337.

Similar proteinsi

Entry informationi

Entry nameiTM35A_BOVIN
AccessioniPrimary (citable) accession number: Q5E9T5
Secondary accession number(s): Q5EAA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 15, 2005
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families