ID   TPK1_BOVIN              Reviewed;         243 AA.
AC   Q5E9T4; Q0P5L2;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   24-JAN-2024, entry version 110.
DE   RecName: Full=Thiamin pyrophosphokinase 1;
DE            EC=2.7.6.2 {ECO:0000250|UniProtKB:Q9R0M5};
DE   AltName: Full=Thiamine pyrophosphokinase 1;
GN   Name=TPK1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the phosphorylation of thiamine to thiamine
CC       pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to
CC       pyrithiamine pyrophosphate. {ECO:0000250|UniProtKB:Q9R0M5}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thiamine = AMP + H(+) + thiamine diphosphate;
CC         Xref=Rhea:RHEA:11576, ChEBI:CHEBI:15378, ChEBI:CHEBI:18385,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58937, ChEBI:CHEBI:456215; EC=2.7.6.2;
CC         Evidence={ECO:0000250|UniProtKB:Q9R0M5};
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis;
CC       thiamine diphosphate from thiamine: step 1/1.
CC       {ECO:0000250|UniProtKB:Q9R0M5}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9R0M5}.
CC   -!- SIMILARITY: Belongs to the thiamine pyrophosphokinase family.
CC       {ECO:0000305}.
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DR   EMBL; BT020836; AAX08853.1; -; mRNA.
DR   EMBL; BC119895; AAI19896.1; -; mRNA.
DR   RefSeq; NP_001073839.1; NM_001080370.1.
DR   RefSeq; XP_005205956.1; XM_005205899.1.
DR   AlphaFoldDB; Q5E9T4; -.
DR   SMR; Q5E9T4; -.
DR   STRING; 9913.ENSBTAP00000074589; -.
DR   PaxDb; 9913-ENSBTAP00000023510; -.
DR   Ensembl; ENSBTAT00000023510.4; ENSBTAP00000023510.3; ENSBTAG00000017676.4.
DR   Ensembl; ENSBTAT00000044036.2; ENSBTAP00000041553.1; ENSBTAG00000017676.4.
DR   Ensembl; ENSBTAT00000066366.1; ENSBTAP00000074589.1; ENSBTAG00000017676.4.
DR   GeneID; 788066; -.
DR   KEGG; bta:788066; -.
DR   CTD; 27010; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017676; -.
DR   VGNC; VGNC:36251; TPK1.
DR   eggNOG; KOG3153; Eukaryota.
DR   GeneTree; ENSGT00390000016016; -.
DR   HOGENOM; CLU_044237_0_1_1; -.
DR   InParanoid; Q5E9T4; -.
DR   OMA; TDMCKAL; -.
DR   TreeFam; TF313224; -.
DR   Reactome; R-BTA-196819; Vitamin B1 (thiamin) metabolism.
DR   UniPathway; UPA00060; UER00597.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000017676; Expressed in oocyte and 104 other cell types or tissues.
DR   ExpressionAtlas; Q5E9T4; baseline and differential.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030975; F:thiamine binding; IEA:InterPro.
DR   GO; GO:0004788; F:thiamine diphosphokinase activity; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006772; P:thiamine metabolic process; IEA:InterPro.
DR   CDD; cd07995; TPK; 1.
DR   Gene3D; 3.40.50.10240; Thiamin pyrophosphokinase, catalytic domain; 1.
DR   Gene3D; 2.60.120.320; Thiamin pyrophosphokinase, thiamin-binding domain; 1.
DR   InterPro; IPR006282; Thi_PPkinase.
DR   InterPro; IPR016966; Thiamin_pyrophosphokinase_euk.
DR   InterPro; IPR007373; Thiamin_PyroPKinase_B1-bd.
DR   InterPro; IPR036371; TPK_B1-bd_sf.
DR   InterPro; IPR007371; TPK_catalytic.
DR   InterPro; IPR036759; TPK_catalytic_sf.
DR   NCBIfam; TIGR01378; thi_PPkinase; 1.
DR   PANTHER; PTHR13622; THIAMIN PYROPHOSPHOKINASE; 1.
DR   PANTHER; PTHR13622:SF8; THIAMIN PYROPHOSPHOKINASE 1; 1.
DR   Pfam; PF04265; TPK_B1_binding; 1.
DR   Pfam; PF04263; TPK_catalytic; 1.
DR   PIRSF; PIRSF031057; Thiamin_pyrophosphokinase; 1.
DR   SMART; SM00983; TPK_B1_binding; 1.
DR   SUPFAM; SSF63999; Thiamin pyrophosphokinase, catalytic domain; 1.
DR   SUPFAM; SSF63862; Thiamin pyrophosphokinase, substrate-binding domain; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..243
FT                   /note="Thiamin pyrophosphokinase 1"
FT                   /id="PRO_0000239117"
SQ   SEQUENCE   243 AA;  27028 MW;  00471681ACC6FB47 CRC64;
     MEHAITPLDP LLPSGSLKYC LVILNQPLDK CFRHLWHKAL LRACADGGAN HLYDVTEGER
     ESFLPEFISG DFDSIRPEVR EHYAIKGCEI ISTPDQDHTD FTKCLEVLQK KIEEKDLQVD
     MIVTLGGLAG RFDQIMASVS TLFQAPQITS LPVIIIQEES LIYLLQPGKH KLHVDTGMEG
     DWCGLIPVGQ PCNQVTTTGL KWNLTHQMLG FGTLVSTSNT YDGSGVVTVE TDHPLLWTMA
     IKN
//