Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5E9T4

- TPK1_BOVIN

UniProt

Q5E9T4 - TPK1_BOVIN

Protein

Thiamin pyrophosphokinase 1

Gene

TPK1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate By similarity.By similarity

    Catalytic activityi

    ATP + thiamine = AMP + thiamine diphosphate.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. kinase activity Source: UniProtKB-KW
    3. thiamine diphosphokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. thiamine metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_206123. Vitamin B1 (thiamin) metabolism.
    UniPathwayiUPA00060; UER00597.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thiamin pyrophosphokinase 1 (EC:2.7.6.2)
    Alternative name(s):
    Thiamine pyrophosphokinase 1
    Gene namesi
    Name:TPK1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243Thiamin pyrophosphokinase 1PRO_0000239117Add
    BLAST

    Proteomic databases

    PRIDEiQ5E9T4.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5E9T4.
    SMRiQ5E9T4. Positions 1-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thiamine pyrophosphokinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1564.
    GeneTreeiENSGT00390000016016.
    HOGENOMiHOG000180834.
    HOVERGENiHBG003568.
    InParanoidiQ5E9T4.
    KOiK00949.
    OMAiNYFRHLW.
    OrthoDBiEOG76HQ2J.
    TreeFamiTF313224.

    Family and domain databases

    Gene3Di2.60.120.320. 1 hit.
    3.40.50.10240. 1 hit.
    InterProiIPR006282. Thi_PPkinase.
    IPR016966. Thiamin_pyrophosphokinase_euk.
    IPR007373. Thiamin_PyroPKinase_B1-bd.
    IPR007371. TPK_catalytic.
    [Graphical view]
    PfamiPF04265. TPK_B1_binding. 1 hit.
    PF04263. TPK_catalytic. 1 hit.
    [Graphical view]
    PIRSFiPIRSF031057. Thiamin_pyrophosphokinase. 1 hit.
    SMARTiSM00983. TPK_B1_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF63862. SSF63862. 1 hit.
    SSF63999. SSF63999. 1 hit.
    TIGRFAMsiTIGR01378. thi_PPkinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5E9T4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHAITPLDP LLPSGSLKYC LVILNQPLDK CFRHLWHKAL LRACADGGAN    50
    HLYDVTEGER ESFLPEFISG DFDSIRPEVR EHYAIKGCEI ISTPDQDHTD 100
    FTKCLEVLQK KIEEKDLQVD MIVTLGGLAG RFDQIMASVS TLFQAPQITS 150
    LPVIIIQEES LIYLLQPGKH KLHVDTGMEG DWCGLIPVGQ PCNQVTTTGL 200
    KWNLTHQMLG FGTLVSTSNT YDGSGVVTVE TDHPLLWTMA IKN 243
    Length:243
    Mass (Da):27,028
    Last modified:March 15, 2005 - v1
    Checksum:i00471681ACC6FB47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020836 mRNA. Translation: AAX08853.1.
    BC119895 mRNA. Translation: AAI19896.1.
    RefSeqiNP_001073839.1. NM_001080370.1.
    XP_005205956.1. XM_005205899.1.
    UniGeneiBt.6512.

    Genome annotation databases

    EnsembliENSBTAT00000023510; ENSBTAP00000023510; ENSBTAG00000017676.
    ENSBTAT00000044036; ENSBTAP00000041553; ENSBTAG00000017676.
    GeneIDi788066.
    KEGGibta:788066.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020836 mRNA. Translation: AAX08853.1 .
    BC119895 mRNA. Translation: AAI19896.1 .
    RefSeqi NP_001073839.1. NM_001080370.1.
    XP_005205956.1. XM_005205899.1.
    UniGenei Bt.6512.

    3D structure databases

    ProteinModelPortali Q5E9T4.
    SMRi Q5E9T4. Positions 1-243.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5E9T4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000023510 ; ENSBTAP00000023510 ; ENSBTAG00000017676 .
    ENSBTAT00000044036 ; ENSBTAP00000041553 ; ENSBTAG00000017676 .
    GeneIDi 788066.
    KEGGi bta:788066.

    Organism-specific databases

    CTDi 27010.

    Phylogenomic databases

    eggNOGi COG1564.
    GeneTreei ENSGT00390000016016.
    HOGENOMi HOG000180834.
    HOVERGENi HBG003568.
    InParanoidi Q5E9T4.
    KOi K00949.
    OMAi NYFRHLW.
    OrthoDBi EOG76HQ2J.
    TreeFami TF313224.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00597 .
    Reactomei REACT_206123. Vitamin B1 (thiamin) metabolism.

    Miscellaneous databases

    NextBioi 20928859.

    Family and domain databases

    Gene3Di 2.60.120.320. 1 hit.
    3.40.50.10240. 1 hit.
    InterProi IPR006282. Thi_PPkinase.
    IPR016966. Thiamin_pyrophosphokinase_euk.
    IPR007373. Thiamin_PyroPKinase_B1-bd.
    IPR007371. TPK_catalytic.
    [Graphical view ]
    Pfami PF04265. TPK_B1_binding. 1 hit.
    PF04263. TPK_catalytic. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF031057. Thiamin_pyrophosphokinase. 1 hit.
    SMARTi SM00983. TPK_B1_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63862. SSF63862. 1 hit.
    SSF63999. SSF63999. 1 hit.
    TIGRFAMsi TIGR01378. thi_PPkinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Basal ganglia.

    Entry informationi

    Entry nameiTPK1_BOVIN
    AccessioniPrimary (citable) accession number: Q5E9T4
    Secondary accession number(s): Q0P5L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3