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Q5E9T4

- TPK1_BOVIN

UniProt

Q5E9T4 - TPK1_BOVIN

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Protein

Thiamin pyrophosphokinase 1

Gene
TPK1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate By similarity.

Catalytic activityi

ATP + thiamine = AMP + thiamine diphosphate.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. kinase activity Source: UniProtKB-KW
  3. thiamine diphosphokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. thiamine metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_206123. Vitamin B1 (thiamin) metabolism.
UniPathwayiUPA00060; UER00597.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamin pyrophosphokinase 1 (EC:2.7.6.2)
Alternative name(s):
Thiamine pyrophosphokinase 1
Gene namesi
Name:TPK1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Thiamin pyrophosphokinase 1PRO_0000239117Add
BLAST

Proteomic databases

PRIDEiQ5E9T4.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5E9T4.
SMRiQ5E9T4. Positions 1-243.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1564.
GeneTreeiENSGT00390000016016.
HOGENOMiHOG000180834.
HOVERGENiHBG003568.
InParanoidiQ5E9T4.
KOiK00949.
OMAiNYFRHLW.
OrthoDBiEOG76HQ2J.
TreeFamiTF313224.

Family and domain databases

Gene3Di2.60.120.320. 1 hit.
3.40.50.10240. 1 hit.
InterProiIPR006282. Thi_PPkinase.
IPR016966. Thiamin_pyrophosphokinase_euk.
IPR007373. Thiamin_PyroPKinase_B1-bd.
IPR007371. TPK_catalytic.
[Graphical view]
PfamiPF04265. TPK_B1_binding. 1 hit.
PF04263. TPK_catalytic. 1 hit.
[Graphical view]
PIRSFiPIRSF031057. Thiamin_pyrophosphokinase. 1 hit.
SMARTiSM00983. TPK_B1_binding. 1 hit.
[Graphical view]
SUPFAMiSSF63862. SSF63862. 1 hit.
SSF63999. SSF63999. 1 hit.
TIGRFAMsiTIGR01378. thi_PPkinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5E9T4-1 [UniParc]FASTAAdd to Basket

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MEHAITPLDP LLPSGSLKYC LVILNQPLDK CFRHLWHKAL LRACADGGAN    50
HLYDVTEGER ESFLPEFISG DFDSIRPEVR EHYAIKGCEI ISTPDQDHTD 100
FTKCLEVLQK KIEEKDLQVD MIVTLGGLAG RFDQIMASVS TLFQAPQITS 150
LPVIIIQEES LIYLLQPGKH KLHVDTGMEG DWCGLIPVGQ PCNQVTTTGL 200
KWNLTHQMLG FGTLVSTSNT YDGSGVVTVE TDHPLLWTMA IKN 243
Length:243
Mass (Da):27,028
Last modified:March 15, 2005 - v1
Checksum:i00471681ACC6FB47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020836 mRNA. Translation: AAX08853.1.
BC119895 mRNA. Translation: AAI19896.1.
RefSeqiNP_001073839.1. NM_001080370.1.
XP_005205956.1. XM_005205899.1.
UniGeneiBt.6512.

Genome annotation databases

EnsembliENSBTAT00000023510; ENSBTAP00000023510; ENSBTAG00000017676.
ENSBTAT00000044036; ENSBTAP00000041553; ENSBTAG00000017676.
GeneIDi788066.
KEGGibta:788066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020836 mRNA. Translation: AAX08853.1 .
BC119895 mRNA. Translation: AAI19896.1 .
RefSeqi NP_001073839.1. NM_001080370.1.
XP_005205956.1. XM_005205899.1.
UniGenei Bt.6512.

3D structure databases

ProteinModelPortali Q5E9T4.
SMRi Q5E9T4. Positions 1-243.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5E9T4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000023510 ; ENSBTAP00000023510 ; ENSBTAG00000017676 .
ENSBTAT00000044036 ; ENSBTAP00000041553 ; ENSBTAG00000017676 .
GeneIDi 788066.
KEGGi bta:788066.

Organism-specific databases

CTDi 27010.

Phylogenomic databases

eggNOGi COG1564.
GeneTreei ENSGT00390000016016.
HOGENOMi HOG000180834.
HOVERGENi HBG003568.
InParanoidi Q5E9T4.
KOi K00949.
OMAi NYFRHLW.
OrthoDBi EOG76HQ2J.
TreeFami TF313224.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00597 .
Reactomei REACT_206123. Vitamin B1 (thiamin) metabolism.

Miscellaneous databases

NextBioi 20928859.

Family and domain databases

Gene3Di 2.60.120.320. 1 hit.
3.40.50.10240. 1 hit.
InterProi IPR006282. Thi_PPkinase.
IPR016966. Thiamin_pyrophosphokinase_euk.
IPR007373. Thiamin_PyroPKinase_B1-bd.
IPR007371. TPK_catalytic.
[Graphical view ]
Pfami PF04265. TPK_B1_binding. 1 hit.
PF04263. TPK_catalytic. 1 hit.
[Graphical view ]
PIRSFi PIRSF031057. Thiamin_pyrophosphokinase. 1 hit.
SMARTi SM00983. TPK_B1_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF63862. SSF63862. 1 hit.
SSF63999. SSF63999. 1 hit.
TIGRFAMsi TIGR01378. thi_PPkinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Basal ganglia.

Entry informationi

Entry nameiTPK1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9T4
Secondary accession number(s): Q0P5L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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