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Q5E9T4 (TPK1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thiamin pyrophosphokinase 1

EC=2.7.6.2
Alternative name(s):
Thiamine pyrophosphokinase 1
Gene names
Name:TPK1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate By similarity.

Catalytic activity

ATP + thiamine = AMP + thiamine diphosphate.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the thiamine pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Thiamin pyrophosphokinase 1
PRO_0000239117

Sequences

Sequence LengthMass (Da)Tools
Q5E9T4 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 00471681ACC6FB47

FASTA24327,028
        10         20         30         40         50         60 
MEHAITPLDP LLPSGSLKYC LVILNQPLDK CFRHLWHKAL LRACADGGAN HLYDVTEGER 

        70         80         90        100        110        120 
ESFLPEFISG DFDSIRPEVR EHYAIKGCEI ISTPDQDHTD FTKCLEVLQK KIEEKDLQVD 

       130        140        150        160        170        180 
MIVTLGGLAG RFDQIMASVS TLFQAPQITS LPVIIIQEES LIYLLQPGKH KLHVDTGMEG 

       190        200        210        220        230        240 
DWCGLIPVGQ PCNQVTTTGL KWNLTHQMLG FGTLVSTSNT YDGSGVVTVE TDHPLLWTMA 


IKN 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Basal ganglia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT020836 mRNA. Translation: AAX08853.1.
BC119895 mRNA. Translation: AAI19896.1.
RefSeqNP_001073839.1. NM_001080370.1.
XP_005205956.1. XM_005205899.1.
UniGeneBt.6512.

3D structure databases

ProteinModelPortalQ5E9T4.
SMRQ5E9T4. Positions 1-243.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ5E9T4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000023510; ENSBTAP00000023510; ENSBTAG00000017676.
ENSBTAT00000044036; ENSBTAP00000041553; ENSBTAG00000017676.
GeneID788066.
KEGGbta:788066.

Organism-specific databases

CTD27010.

Phylogenomic databases

eggNOGCOG1564.
GeneTreeENSGT00390000016016.
HOGENOMHOG000180834.
HOVERGENHBG003568.
InParanoidQ5E9T4.
KOK00949.
OMANYFRHLW.
OrthoDBEOG76HQ2J.
TreeFamTF313224.

Enzyme and pathway databases

UniPathwayUPA00060; UER00597.

Family and domain databases

Gene3D2.60.120.320. 1 hit.
3.40.50.10240. 1 hit.
InterProIPR006282. Thi_PPkinase.
IPR016966. Thiamin_pyrophosphokinase_euk.
IPR007373. Thiamin_PyroPKinase_B1-bd.
IPR007371. TPK_catalytic.
[Graphical view]
PfamPF04265. TPK_B1_binding. 1 hit.
PF04263. TPK_catalytic. 1 hit.
[Graphical view]
PIRSFPIRSF031057. Thiamin_pyrophosphokinase. 1 hit.
SMARTSM00983. TPK_B1_binding. 1 hit.
[Graphical view]
SUPFAMSSF63862. SSF63862. 1 hit.
SSF63999. SSF63999. 1 hit.
TIGRFAMsTIGR01378. thi_PPkinase. 1 hit.
ProtoNetSearch...

Other

NextBio20928859.

Entry information

Entry nameTPK1_BOVIN
AccessionPrimary (citable) accession number: Q5E9T4
Secondary accession number(s): Q0P5L2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 15, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways