Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ethanolamine-phosphate phospho-lyase

Gene

ETNPPL

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.By similarity

Catalytic activityi

Ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate.

Cofactori

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Lyase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-BTA-1483213. Synthesis of PE.

Names & Taxonomyi

Protein namesi
Recommended name:
Ethanolamine-phosphate phospho-lyase (EC:4.2.3.2)
Alternative name(s):
Alanine--glyoxylate aminotransferase 2-like 1
Gene namesi
Name:ETNPPL
Synonyms:AGXT2L1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876621 – 497Ethanolamine-phosphate phospho-lyaseAdd BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ5E9S4.
PRIDEiQ5E9S4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000010284.

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013587.

Structurei

3D structure databases

ProteinModelPortaliQ5E9S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1403. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00530000062907.
HOGENOMiHOG000020206.
HOVERGENiHBG004196.
InParanoidiQ5E9S4.
KOiK14286.
OMAiCKVFFAS.
OrthoDBiEOG091G08ZM.
TreeFamiTF320468.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E9S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCELYSKQET LALRRKHIGP SCKVFFAADP IKIVRAQRQY MFDEKGDQYL
60 70 80 90 100
DCINNVAHVG HCHPEVVKAA QKQMELLNTN SRFLHDNIVE YAKRLSATLP
110 120 130 140 150
DRLSVCYFTN SGSEANDLAL RLARQFRGHQ DVITLDHAYH GHLSSLIEIS
160 170 180 190 200
PYKFQKGKDV KKEFVHVAPA PDTYRGKYRE DHVDPASAYA DEVKKIIDEA
210 220 230 240 250
HNSGRKIAAF IAESMQSCGG QIIPPAGYFQ KVAEYVRGAG GVFIADEVQV
260 270 280 290 300
GFGRVGKHFW SFQMFGEDFV PDIVTMGKPM GNGHPMACVV TTKEIAEAFS
310 320 330 340 350
ASGMEYFNTY GGNPVSSAVG LAVLDVIKNE DLQGNATRVG NYLTELLNKQ
360 370 380 390 400
KTKHTLIGDI RGVGLFIGID LVKDHQQRTP ATAEAQHIIY KMKEKRVLLS
410 420 430 440 450
ADGPHRNVLK IKPPMCFTEE DAKFMVEQLD GILTGLEEAT GAETESGISK
460 470 480 490
NTPCRTKMPK EAQSELLRDS SLESRENPSQ KRNGLCTDSL LSKRLRT
Length:497
Mass (Da):55,313
Last modified:March 15, 2005 - v1
Checksum:i5D9130D11A0BD752
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020846 mRNA. Translation: AAX08863.1.
BC123420 mRNA. Translation: AAI23421.1.
RefSeqiNP_001015605.1. NM_001015605.1.
UniGeneiBt.13287.

Genome annotation databases

EnsembliENSBTAT00000013587; ENSBTAP00000013587; ENSBTAG00000010284.
GeneIDi515186.
KEGGibta:515186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020846 mRNA. Translation: AAX08863.1.
BC123420 mRNA. Translation: AAI23421.1.
RefSeqiNP_001015605.1. NM_001015605.1.
UniGeneiBt.13287.

3D structure databases

ProteinModelPortaliQ5E9S4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013587.

Proteomic databases

PaxDbiQ5E9S4.
PRIDEiQ5E9S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013587; ENSBTAP00000013587; ENSBTAG00000010284.
GeneIDi515186.
KEGGibta:515186.

Organism-specific databases

CTDi64850.

Phylogenomic databases

eggNOGiKOG1403. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00530000062907.
HOGENOMiHOG000020206.
HOVERGENiHBG004196.
InParanoidiQ5E9S4.
KOiK14286.
OMAiCKVFFAS.
OrthoDBiEOG091G08ZM.
TreeFamiTF320468.

Enzyme and pathway databases

ReactomeiR-BTA-1483213. Synthesis of PE.

Gene expression databases

BgeeiENSBTAG00000010284.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT2L1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.