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Protein

Nuclear transcription factor Y subunit alpha

Gene

NFYA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi290 – 31526NFYA/HAP2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-2426168. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit alpha
Alternative name(s):
CAAT box DNA-binding protein subunit A
Nuclear transcription factor Y subunit A
Short name:
NF-YA
Gene namesi
Name:NFYA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 23

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Nuclear transcription factor Y subunit alphaPRO_0000198767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei320 – 3201PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5E9S2.
PRIDEiQ5E9S2.

Expressioni

Gene expression databases

ExpressionAtlasiQ5E9S2. baseline.

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity). Interacts with SP1; the interaction is inhibited by glycosylation of SP1. Interacts (via N-terminus) with ZHX2 (via homeobox domain). Interacts with ZFX3. Interacts with ZHX1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013080.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi260 – 28324Subunit association domain (SAD)Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 161148Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the NFYA/HAP2 subunit family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1561. Eukaryota.
COG5224. LUCA.
GeneTreeiENSGT00390000015714.
HOGENOMiHOG000247016.
HOVERGENiHBG005253.
InParanoidiQ5E9S2.
KOiK08064.
OMAiTQMIRVS.
TreeFamiTF323257.

Family and domain databases

InterProiIPR018362. CCAAT-binding_factor_CS.
IPR001289. NFYA.
[Graphical view]
PANTHERiPTHR12632. PTHR12632. 1 hit.
PfamiPF02045. CBFB_NFYA. 1 hit.
[Graphical view]
PRINTSiPR00616. CCAATSUBUNTB.
SMARTiSM00521. CBF. 1 hit.
[Graphical view]
PROSITEiPS00686. NFYA_HAP2_1. 1 hit.
PS51152. NFYA_HAP2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E9S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQYAANSNS SAEQIVVQAG QIQQQQQGGV TAVQLQTEAQ VASASGQQVQ
60 70 80 90 100
TLQVVQGQPL MVQVSGGQLI TSTGQPIMVQ AVPGGQGQTI MQVPVSGTQG
110 120 130 140 150
LQQIQLVPPG QIQIQGGQAV QVQGQQGQTQ QIIIQQPQTA VTAGQTQTQQ
160 170 180 190 200
QIAVQGQQVA QTAEGQTIVY QPVNADGTIL QQGMITIPAA SLAGAQIVQT
210 220 230 240 250
GANTNTTSSG QGTVTVTLPV AGNVVNSGGM VMMVPGAGSV PAIQRIPLPG
260 270 280 290 300
AEMLEEEPLY VNAKQYHRIL KRRQARAKLE AEGKIPKERR KYLHESRHRH
310 320 330 340
AMARKRGEGG RFFSPKEKDS PHMQDPNQAD EEAMTQIIRV S
Length:341
Mass (Da):36,234
Last modified:March 15, 2005 - v1
Checksum:iB1A118D4D2BB13D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020848 mRNA. Translation: AAX08865.1.
RefSeqiNP_001014956.1. NM_001014956.1.
UniGeneiBt.91604.

Genome annotation databases

EnsembliENSBTAT00000013080; ENSBTAP00000013080; ENSBTAG00000009905.
GeneIDi539584.
KEGGibta:539584.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020848 mRNA. Translation: AAX08865.1.
RefSeqiNP_001014956.1. NM_001014956.1.
UniGeneiBt.91604.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013080.

Proteomic databases

PaxDbiQ5E9S2.
PRIDEiQ5E9S2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013080; ENSBTAP00000013080; ENSBTAG00000009905.
GeneIDi539584.
KEGGibta:539584.

Organism-specific databases

CTDi4800.

Phylogenomic databases

eggNOGiKOG1561. Eukaryota.
COG5224. LUCA.
GeneTreeiENSGT00390000015714.
HOGENOMiHOG000247016.
HOVERGENiHBG005253.
InParanoidiQ5E9S2.
KOiK08064.
OMAiTQMIRVS.
TreeFamiTF323257.

Enzyme and pathway databases

ReactomeiR-BTA-2426168. Activation of gene expression by SREBF (SREBP).

Gene expression databases

ExpressionAtlasiQ5E9S2. baseline.

Family and domain databases

InterProiIPR018362. CCAAT-binding_factor_CS.
IPR001289. NFYA.
[Graphical view]
PANTHERiPTHR12632. PTHR12632. 1 hit.
PfamiPF02045. CBFB_NFYA. 1 hit.
[Graphical view]
PRINTSiPR00616. CCAATSUBUNTB.
SMARTiSM00521. CBF. 1 hit.
[Graphical view]
PROSITEiPS00686. NFYA_HAP2_1. 1 hit.
PS51152. NFYA_HAP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiNFYA_BOVIN
AccessioniPrimary (citable) accession number: Q5E9S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.