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Protein

Ceramide synthase 4

Gene

CERS4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi67 – 128HomeoboxPROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide synthase 4
Short name:
CerS4
Alternative name(s):
LAG1 longevity assurance homolog 4
Gene namesi
Name:CERS4
Synonyms:LASS4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404471 – 393Ceramide synthase 4Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei342PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5E9R6.
PRIDEiQ5E9R6.

Expressioni

Gene expression databases

BgeeiENSBTAG00000003434.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004459.

Structurei

3D structure databases

ProteinModelPortaliQ5E9R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 332TLCPROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOVERGENiHBG052310.
InParanoidiQ5E9R6.
KOiK04710.
OMAiRVCDALF.
OrthoDBiEOG091G0BWM.
TreeFamiTF314319.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E9R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSSLNDWLW NERLWLPANI SWAQLEDHDG LVFPHPQDTL MAVPLALALV
60 70 80 90 100
VVRFTFERFV ALPLSRWLGV RNQIRRPADP NATLEKHYLM KGREPTESQM
110 120 130 140 150
NLLATQCGLT LRQTQCWFRR RRNQDRPCLT KKFCESSWKF VFYLCCFVCG
160 170 180 190 200
TMVLYHESWL WTPVKCWENY PHQPLKPGLY HWYLLELSFY ISLLMTLPFD
210 220 230 240 250
TKRKDFKEQV IHHFVTIILI SFSYSLNLLR IGSLVLLLHD SADYLLEASK
260 270 280 290 300
LFNYMHWRRM CDTLFIIFSL VFFYTRLVLF PTRILYTTFF ESIGNFSPFF
310 320 330 340 350
GYYFLNILLV ILQLLHVFWS WLILCMIYSF IKKGQMEKDV RSDVEELDSS
360 370 380 390
DGEAAEECPQ MKNGAAQRPG AAPTDGPRSR AAGRMVNRHT PAT
Length:393
Mass (Da):46,363
Last modified:March 15, 2005 - v1
Checksum:i3F443D400F9CF8B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020828 mRNA. Translation: AAX08845.1.
BT020854 mRNA. Translation: AAX08871.1.
BT026335 mRNA. Translation: ABG81491.1.
BC120450 mRNA. Translation: AAI20451.1.
RefSeqiNP_001015520.1. NM_001015520.1.
XP_005208907.1. XM_005208850.2.
XP_010805210.1. XM_010806908.2.
UniGeneiBt.2268.

Genome annotation databases

EnsembliENSBTAT00000004459; ENSBTAP00000004459; ENSBTAG00000003434.
GeneIDi505233.
KEGGibta:505233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020828 mRNA. Translation: AAX08845.1.
BT020854 mRNA. Translation: AAX08871.1.
BT026335 mRNA. Translation: ABG81491.1.
BC120450 mRNA. Translation: AAI20451.1.
RefSeqiNP_001015520.1. NM_001015520.1.
XP_005208907.1. XM_005208850.2.
XP_010805210.1. XM_010806908.2.
UniGeneiBt.2268.

3D structure databases

ProteinModelPortaliQ5E9R6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004459.

Proteomic databases

PaxDbiQ5E9R6.
PRIDEiQ5E9R6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004459; ENSBTAP00000004459; ENSBTAG00000003434.
GeneIDi505233.
KEGGibta:505233.

Organism-specific databases

CTDi79603.

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOVERGENiHBG052310.
InParanoidiQ5E9R6.
KOiK04710.
OMAiRVCDALF.
OrthoDBiEOG091G0BWM.
TreeFamiTF314319.

Enzyme and pathway databases

ReactomeiR-BTA-1660661. Sphingolipid de novo biosynthesis.

Gene expression databases

BgeeiENSBTAG00000003434.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR016439. Lag1/Lac1.
IPR006634. TLC-dom.
[Graphical view]
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCERS4_BOVIN
AccessioniPrimary (citable) accession number: Q5E9R6
Secondary accession number(s): Q0V884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.