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Q5E9Q1

- PGLT1_BOVIN

UniProt

Q5E9Q1 - PGLT1_BOVIN

Protein

Protein O-glucosyltransferase 1

Gene

POGLUT1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding By similarity.By similarity

    Catalytic activityi

    Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.

    Pathwayi

    GO - Molecular functioni

    1. protein xylosyltransferase activity Source: UniProtKB-EC
    2. UDP-glucosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. cardiovascular system development Source: Ensembl
    2. protein O-linked glycosylation Source: Ensembl
    3. regulation of Notch signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciCATTLE:511862-MONOMER.
    ReactomeiREACT_205604. Pre-NOTCH Processing in the Endoplasmic Reticulum.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT90. Glycosyltransferase Family 90.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein O-glucosyltransferase 1 (EC:2.4.1.-)
    Alternative name(s):
    CAP10-like 46 kDa protein
    KTEL motif-containing protein 1
    O-glucosyltransferase Rumi homolog
    Short name:
    Rumi
    Protein O-xylosyltransferase (EC:2.4.2.26)
    Gene namesi
    Name:POGLUT1
    Synonyms:CLP46, KTELC1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 392369Protein O-glucosyltransferase 1PRO_0000246684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5E9Q1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000011287.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi389 – 3924Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the glycosyltransferase 90 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248922.
    GeneTreeiENSGT00530000063132.
    HOVERGENiHBG069044.
    InParanoidiQ5E9Q1.
    KOiK13667.
    OMAiINHLQMD.
    OrthoDBiEOG7R831J.
    TreeFamiTF323280.

    Family and domain databases

    InterProiIPR006598. LipoPS_modifying.
    [Graphical view]
    PfamiPF05686. Glyco_transf_90. 1 hit.
    [Graphical view]
    SMARTiSM00672. CAP10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5E9Q1-1 [UniParc]FASTAAdd to Basket

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    MELGVSSQLW LWLLLLLLPP VPGREKESGS KWKVFIDQIN RALENYEPCS    50
    SPNCSCYHGV IEEDLTPFRG GISRKMMAEV VRRKLGTHYQ IIKNRLYRES 100
    DCMFPSRCSG VEHFILEVIG RLPDMEMVIN VRDYPQVPKW MEPAIPIFSF 150
    SKTLEYHDIM YPAWTFWEGG PAVWPIYPMG LGRWDLFRED LVRSAAQWPW 200
    KKKNSTAYFR GSRTSPERDP LILLSRKNPK LVDAEYTKNQ AWKSMKDTLG 250
    KPAAKDVHLV DHCKYKYLFN FRGVAASFRF KHLFLCGSLV FHVGDEWLEF 300
    FYPQLKPWVH YIPVKTDLSN VQELLQFVKA NDDVAQEIAE RGSQFILNHL 350
    KMDDITCYWE NLLTEYSKFL SYNVTRRKGY DQIVPKILKI EL 392
    Length:392
    Mass (Da):46,009
    Last modified:March 15, 2005 - v1
    Checksum:i59FF5C0B59429DEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020869 mRNA. Translation: AAX08886.1.
    RefSeqiNP_001014903.1. NM_001014903.1.
    UniGeneiBt.33308.

    Genome annotation databases

    EnsembliENSBTAT00000011287; ENSBTAP00000011287; ENSBTAG00000008562.
    GeneIDi511862.
    KEGGibta:511862.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020869 mRNA. Translation: AAX08886.1 .
    RefSeqi NP_001014903.1. NM_001014903.1.
    UniGenei Bt.33308.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000011287.

    Protein family/group databases

    CAZyi GT90. Glycosyltransferase Family 90.

    Proteomic databases

    PRIDEi Q5E9Q1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000011287 ; ENSBTAP00000011287 ; ENSBTAG00000008562 .
    GeneIDi 511862.
    KEGGi bta:511862.

    Organism-specific databases

    CTDi 56983.

    Phylogenomic databases

    eggNOGi NOG248922.
    GeneTreei ENSGT00530000063132.
    HOVERGENi HBG069044.
    InParanoidi Q5E9Q1.
    KOi K13667.
    OMAi INHLQMD.
    OrthoDBi EOG7R831J.
    TreeFami TF323280.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BioCyci CATTLE:511862-MONOMER.
    Reactomei REACT_205604. Pre-NOTCH Processing in the Endoplasmic Reticulum.

    Miscellaneous databases

    NextBioi 20870134.

    Family and domain databases

    InterProi IPR006598. LipoPS_modifying.
    [Graphical view ]
    Pfami PF05686. Glyco_transf_90. 1 hit.
    [Graphical view ]
    SMARTi SM00672. CAP10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiPGLT1_BOVIN
    AccessioniPrimary (citable) accession number: Q5E9Q1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3