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Q5E9Q1

- PGLT1_BOVIN

UniProt

Q5E9Q1 - PGLT1_BOVIN

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Protein

Protein O-glucosyltransferase 1

Gene
POGLUT1, CLP46, KTELC1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding By similarity.

Catalytic activityi

Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.

Pathwayi

GO - Molecular functioni

  1. protein xylosyltransferase activity Source: UniProtKB-EC
  2. UDP-glucosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. cardiovascular system development Source: Ensembl
  2. protein O-linked glycosylation Source: Ensembl
  3. regulation of Notch signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciCATTLE:511862-MONOMER.
ReactomeiREACT_205604. Pre-NOTCH Processing in the Endoplasmic Reticulum.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-glucosyltransferase 1 (EC:2.4.1.-)
Alternative name(s):
CAP10-like 46 kDa protein
KTEL motif-containing protein 1
O-glucosyltransferase Rumi homolog
Short name:
Rumi
Protein O-xylosyltransferase (EC:2.4.2.26)
Gene namesi
Name:POGLUT1
Synonyms:CLP46, KTELC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 392369Protein O-glucosyltransferase 1PRO_0000246684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi204 – 2041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi373 – 3731N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5E9Q1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011287.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi389 – 3924Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
GeneTreeiENSGT00530000063132.
HOVERGENiHBG069044.
InParanoidiQ5E9Q1.
KOiK13667.
OMAiINHLQMD.
OrthoDBiEOG7R831J.
TreeFamiTF323280.

Family and domain databases

InterProiIPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9Q1-1 [UniParc]FASTAAdd to Basket

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MELGVSSQLW LWLLLLLLPP VPGREKESGS KWKVFIDQIN RALENYEPCS    50
SPNCSCYHGV IEEDLTPFRG GISRKMMAEV VRRKLGTHYQ IIKNRLYRES 100
DCMFPSRCSG VEHFILEVIG RLPDMEMVIN VRDYPQVPKW MEPAIPIFSF 150
SKTLEYHDIM YPAWTFWEGG PAVWPIYPMG LGRWDLFRED LVRSAAQWPW 200
KKKNSTAYFR GSRTSPERDP LILLSRKNPK LVDAEYTKNQ AWKSMKDTLG 250
KPAAKDVHLV DHCKYKYLFN FRGVAASFRF KHLFLCGSLV FHVGDEWLEF 300
FYPQLKPWVH YIPVKTDLSN VQELLQFVKA NDDVAQEIAE RGSQFILNHL 350
KMDDITCYWE NLLTEYSKFL SYNVTRRKGY DQIVPKILKI EL 392
Length:392
Mass (Da):46,009
Last modified:March 15, 2005 - v1
Checksum:i59FF5C0B59429DEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020869 mRNA. Translation: AAX08886.1.
RefSeqiNP_001014903.1. NM_001014903.1.
UniGeneiBt.33308.

Genome annotation databases

EnsembliENSBTAT00000011287; ENSBTAP00000011287; ENSBTAG00000008562.
GeneIDi511862.
KEGGibta:511862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020869 mRNA. Translation: AAX08886.1 .
RefSeqi NP_001014903.1. NM_001014903.1.
UniGenei Bt.33308.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000011287.

Protein family/group databases

CAZyi GT90. Glycosyltransferase Family 90.

Proteomic databases

PRIDEi Q5E9Q1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000011287 ; ENSBTAP00000011287 ; ENSBTAG00000008562 .
GeneIDi 511862.
KEGGi bta:511862.

Organism-specific databases

CTDi 56983.

Phylogenomic databases

eggNOGi NOG248922.
GeneTreei ENSGT00530000063132.
HOVERGENi HBG069044.
InParanoidi Q5E9Q1.
KOi K13667.
OMAi INHLQMD.
OrthoDBi EOG7R831J.
TreeFami TF323280.

Enzyme and pathway databases

UniPathwayi UPA00378 .
BioCyci CATTLE:511862-MONOMER.
Reactomei REACT_205604. Pre-NOTCH Processing in the Endoplasmic Reticulum.

Miscellaneous databases

NextBioi 20870134.

Family and domain databases

InterProi IPR006598. LipoPS_modifying.
[Graphical view ]
Pfami PF05686. Glyco_transf_90. 1 hit.
[Graphical view ]
SMARTi SM00672. CAP10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPGLT1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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