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Protein

Protein O-glucosyltransferase 1

Gene

POGLUT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding (By similarity).By similarity

Catalytic activityi

Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.

Pathway: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciCATTLE:511862-MONOMER.
ReactomeiREACT_282150. Pre-NOTCH Processing in the Endoplasmic Reticulum.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein O-glucosyltransferase 1 (EC:2.4.1.-)
Alternative name(s):
CAP10-like 46 kDa protein
KTEL motif-containing protein 1
O-glucosyltransferase Rumi homolog
Short name:
Rumi
Protein O-xylosyltransferase (EC:2.4.2.26)
Gene namesi
Name:POGLUT1
Synonyms:CLP46, KTELC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 392369Protein O-glucosyltransferase 1PRO_0000246684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi204 – 2041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5E9Q1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011287.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi389 – 3924Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the glycosyltransferase 90 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
GeneTreeiENSGT00530000063132.
HOVERGENiHBG069044.
InParanoidiQ5E9Q1.
KOiK13667.
OMAiNMDLVIN.
OrthoDBiEOG7R831J.
TreeFamiTF323280.

Family and domain databases

InterProiIPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGVSSQLW LWLLLLLLPP VPGREKESGS KWKVFIDQIN RALENYEPCS
60 70 80 90 100
SPNCSCYHGV IEEDLTPFRG GISRKMMAEV VRRKLGTHYQ IIKNRLYRES
110 120 130 140 150
DCMFPSRCSG VEHFILEVIG RLPDMEMVIN VRDYPQVPKW MEPAIPIFSF
160 170 180 190 200
SKTLEYHDIM YPAWTFWEGG PAVWPIYPMG LGRWDLFRED LVRSAAQWPW
210 220 230 240 250
KKKNSTAYFR GSRTSPERDP LILLSRKNPK LVDAEYTKNQ AWKSMKDTLG
260 270 280 290 300
KPAAKDVHLV DHCKYKYLFN FRGVAASFRF KHLFLCGSLV FHVGDEWLEF
310 320 330 340 350
FYPQLKPWVH YIPVKTDLSN VQELLQFVKA NDDVAQEIAE RGSQFILNHL
360 370 380 390
KMDDITCYWE NLLTEYSKFL SYNVTRRKGY DQIVPKILKI EL
Length:392
Mass (Da):46,009
Last modified:March 15, 2005 - v1
Checksum:i59FF5C0B59429DEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020869 mRNA. Translation: AAX08886.1.
RefSeqiNP_001014903.1. NM_001014903.1.
UniGeneiBt.33308.

Genome annotation databases

EnsembliENSBTAT00000011287; ENSBTAP00000011287; ENSBTAG00000008562.
GeneIDi511862.
KEGGibta:511862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020869 mRNA. Translation: AAX08886.1.
RefSeqiNP_001014903.1. NM_001014903.1.
UniGeneiBt.33308.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011287.

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Proteomic databases

PRIDEiQ5E9Q1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011287; ENSBTAP00000011287; ENSBTAG00000008562.
GeneIDi511862.
KEGGibta:511862.

Organism-specific databases

CTDi56983.

Phylogenomic databases

eggNOGiNOG248922.
GeneTreeiENSGT00530000063132.
HOVERGENiHBG069044.
InParanoidiQ5E9Q1.
KOiK13667.
OMAiNMDLVIN.
OrthoDBiEOG7R831J.
TreeFamiTF323280.

Enzyme and pathway databases

UniPathwayiUPA00378.
BioCyciCATTLE:511862-MONOMER.
ReactomeiREACT_282150. Pre-NOTCH Processing in the Endoplasmic Reticulum.

Miscellaneous databases

NextBioi20870134.

Family and domain databases

InterProiIPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPGLT1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2005
Last modified: May 27, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.