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Q5E9Q1 (PGLT1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein O-glucosyltransferase 1

EC=2.4.1.-
Alternative name(s):
CAP10-like 46 kDa protein
KTEL motif-containing protein 1
O-glucosyltransferase Rumi homolog
Short name=Rumi
Protein O-xylosyltransferase
EC=2.4.2.26
Gene names
Name:POGLUT1
Synonyms:CLP46, KTELC1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding By similarity.

Catalytic activity

Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the glycosyltransferase 90 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 392369Protein O-glucosyltransferase 1
PRO_0000246684

Regions

Motif389 – 3924Prevents secretion from ER Potential

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation2041N-linked (GlcNAc...) Potential
Glycosylation3731N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5E9Q1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 59FF5C0B59429DEC

FASTA39246,009
        10         20         30         40         50         60 
MELGVSSQLW LWLLLLLLPP VPGREKESGS KWKVFIDQIN RALENYEPCS SPNCSCYHGV 

        70         80         90        100        110        120 
IEEDLTPFRG GISRKMMAEV VRRKLGTHYQ IIKNRLYRES DCMFPSRCSG VEHFILEVIG 

       130        140        150        160        170        180 
RLPDMEMVIN VRDYPQVPKW MEPAIPIFSF SKTLEYHDIM YPAWTFWEGG PAVWPIYPMG 

       190        200        210        220        230        240 
LGRWDLFRED LVRSAAQWPW KKKNSTAYFR GSRTSPERDP LILLSRKNPK LVDAEYTKNQ 

       250        260        270        280        290        300 
AWKSMKDTLG KPAAKDVHLV DHCKYKYLFN FRGVAASFRF KHLFLCGSLV FHVGDEWLEF 

       310        320        330        340        350        360 
FYPQLKPWVH YIPVKTDLSN VQELLQFVKA NDDVAQEIAE RGSQFILNHL KMDDITCYWE 

       370        380        390 
NLLTEYSKFL SYNVTRRKGY DQIVPKILKI EL 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT020869 mRNA. Translation: AAX08886.1.
RefSeqNP_001014903.1. NM_001014903.1.
UniGeneBt.33308.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000011287.

Protein family/group databases

CAZyGT90. Glycosyltransferase Family 90.

Proteomic databases

PRIDEQ5E9Q1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000011287; ENSBTAP00000011287; ENSBTAG00000008562.
GeneID511862.
KEGGbta:511862.

Organism-specific databases

CTD56983.

Phylogenomic databases

eggNOGNOG248922.
GeneTreeENSGT00530000063132.
HOVERGENHBG069044.
InParanoidQ5E9Q1.
KOK13667.
OMAINHLQMD.
OrthoDBEOG7R831J.
TreeFamTF323280.

Enzyme and pathway databases

BioCycCATTLE:511862-MONOMER.
UniPathwayUPA00378.

Family and domain databases

InterProIPR006598. LipoPS_modifying.
[Graphical view]
PfamPF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTSM00672. CAP10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870134.

Entry information

Entry namePGLT1_BOVIN
AccessionPrimary (citable) accession number: Q5E9Q1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways