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Protein

Sphingosine 1-phosphate receptor 1

Gene

S1PR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processAngiogenesis, Chemotaxis

Enzyme and pathway databases

ReactomeiR-BTA-418594 G alpha (i) signalling events
R-BTA-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 1
Short name:
S1P receptor 1
Short name:
S1P1
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 1
Sphingosine 1-phosphate receptor Edg-1
Short name:
S1P receptor Edg-1
CD_antigen: CD363
Gene namesi
Name:S1PR1
Synonyms:EDG1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:34252 S1PR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46ExtracellularBy similarityAdd BLAST46
Transmembranei47 – 68Helical; Name=1By similarityAdd BLAST22
Topological domaini69 – 82CytoplasmicBy similarityAdd BLAST14
Transmembranei83 – 104Helical; Name=2By similarityAdd BLAST22
Topological domaini105 – 116ExtracellularBy similarityAdd BLAST12
Transmembranei117 – 138Helical; Name=3By similarityAdd BLAST22
Topological domaini139 – 160CytoplasmicBy similarityAdd BLAST22
Transmembranei161 – 182Helical; Name=4By similarityAdd BLAST22
Topological domaini183 – 196ExtracellularBy similarityAdd BLAST14
Transmembranei197 – 224Helical; Name=5By similarityAdd BLAST28
Topological domaini225 – 257CytoplasmicBy similarityAdd BLAST33
Transmembranei258 – 278Helical; Name=6By similarityAdd BLAST21
Topological domaini279 – 289ExtracellularBy similarityAdd BLAST11
Transmembranei290 – 310Helical; Name=7By similarityAdd BLAST21
Topological domaini311 – 382CytoplasmicBy similarityAdd BLAST72

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002446211 – 382Sphingosine 1-phosphate receptor 1Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10N6-acetyllysineBy similarity1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi184 ↔ 191PROSITE-ProRule annotation
Modified residuei236Phosphothreonine; by PKB/AKT1By similarity1
Disulfide bondi282 ↔ 287PROSITE-ProRule annotation
Lipidationi328S-palmitoyl cysteineBy similarity1
Modified residuei351PhosphoserineBy similarity1
Modified residuei353PhosphoserineSequence analysis1

Post-translational modificationi

S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ5E9P3
PRIDEiQ5E9P3

Expressioni

Gene expression databases

BgeeiENSBTAG00000005990

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAI3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007861

Structurei

3D structure databases

ProteinModelPortaliQ5E9P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 121Sphingosine 1-phosphate bindingBy similarity2
Regioni265 – 269Sphingosine 1-phosphate bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIA7 Eukaryota
ENOG410XQD3 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ5E9P3
KOiK04288
OMAiCFIACWA
OrthoDBiEOG091G0DD4
TreeFamiTF330052

Family and domain databases

InterProiView protein in InterPro
IPR000987 EDG1_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00642 EDG1RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E9P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTRIPLVK ALHSPVSDYV NYDIIVRHYN YTGKLKISAD KDNGIKLISV
60 70 80 90 100
VFILICCFII LENIFVLLTI WKTKKFHRPM YYFIGNLALS DLLAGVAYTA
110 120 130 140 150
NLLLSGATTY KLTPAQWFLR EGSMFVALSA SVFSLLAIAI ERYITMLKMK
160 170 180 190 200
LHNGSNRFRS FLLISACWVI SLILGGLPIM GWNCISTLPS CSTVLPLYHK
210 220 230 240 250
HYILFCTTVF TLLLLSIVIL YCRIYSLVRT RSRRLTFRKN ISKASRSSEK
260 270 280 290 300
SLALLKTVII VLGVFIACWA PLFILLLLDV GCKVKTCDIL FRTEYFLVLA
310 320 330 340 350
VLNSGTNPII YTLSNKEMRR AFVRIMSCCK CPSRDSASKF TRPIIAGMEF
360 370 380
SRSKSDNSSH PQKDDGDNPE TIMSSGNVNS SS
Length:382
Mass (Da):42,949
Last modified:March 15, 2005 - v1
Checksum:i81C19138BDFB8880
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020877 mRNA Translation: AAX08894.1
BC114045 mRNA Translation: AAI14046.1
RefSeqiNP_001013603.2, NM_001013585.4
UniGeneiBt.26265

Genome annotation databases

EnsembliENSBTAT00000007861; ENSBTAP00000007861; ENSBTAG00000005990
GeneIDi281135
KEGGibta:281135

Similar proteinsi

Entry informationi

Entry nameiS1PR1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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