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Protein

PRA1 family protein 3

Gene

ARL6IP5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-210500. Glutamate Neurotransmitter Release Cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
PRA1 family protein 3
Alternative name(s):
ADP-ribosylation factor-like protein 6-interacting protein 5
Short name:
ARL-6-interacting protein 5
Short name:
Aip-5
Gene namesi
Name:ARL6IP5
Synonyms:PRAF3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasm By similarity
  • Cytoplasmcytoskeleton By similarity

  • Note: Also exists as a soluble form in the cytoplasm. Associated with microtubules.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicBy similarityAdd
BLAST
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Topological domaini78 – 9316CytoplasmicBy similarityAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence analysisAdd
BLAST
Topological domaini136 – 18853CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188PRA1 family protein 3PRO_0000256847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5E9M1.
PRIDEiQ5E9M1.

Interactioni

Subunit structurei

Homodimer. Heterodimer with ARL6IP1. Forms multimers. Interacts with prenylated RAB1A, RAB3A and SLC1A1/EAAC1. Does not interact with VAMP1, VAMP2 or VAMP3. Interacts with ARL6. Interacts with SLC1A1/EAAC1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028661.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni103 – 11715Required for homodimer formation and heterodimer formation with ARL6IP1By similarityAdd
BLAST
Regioni136 – 18853Targeting to endoplasmic reticulum membraneBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the PRA1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4050. Eukaryota.
ENOG4111MUC. LUCA.
GeneTreeiENSGT00390000008631.
HOGENOMiHOG000231363.
HOVERGENiHBG053661.
InParanoidiQ5E9M1.
OMAiISNLMYY.
OrthoDBiEOG7VDXQH.
TreeFamiTF105479.

Family and domain databases

InterProiIPR004895. Prenylated_rab_accept_PRA1.
[Graphical view]
PfamiPF03208. PRA1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E9M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVNIAPLRA WDDFFPGSDR FARPDFRDIS KWNNRVVSNL LYYQTNYLVV
60 70 80 90 100
AAMMISVVGF LSPFNMILGG IVVVLVFTGF VWAAHNKDIL RRMKKQYPTA
110 120 130 140 150
FVMVVMLASY FLISLFGGVM VFVFGITFPL LLMFIHASLR LRNLKNKLEN
160 170 180
KMEEIGLKRT PMGIVLDALE QQEETITKFS DYISKMKE
Length:188
Mass (Da):21,666
Last modified:March 15, 2005 - v1
Checksum:iDDCB3D3CC815AF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020899 mRNA. Translation: AAX08916.1.
BC102757 mRNA. Translation: AAI02758.1.
RefSeqiNP_001014891.1. NM_001014891.1.
UniGeneiBt.13574.

Genome annotation databases

EnsembliENSBTAT00000028661; ENSBTAP00000028661; ENSBTAG00000021506.
GeneIDi509977.
KEGGibta:509977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020899 mRNA. Translation: AAX08916.1.
BC102757 mRNA. Translation: AAI02758.1.
RefSeqiNP_001014891.1. NM_001014891.1.
UniGeneiBt.13574.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028661.

Proteomic databases

PaxDbiQ5E9M1.
PRIDEiQ5E9M1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028661; ENSBTAP00000028661; ENSBTAG00000021506.
GeneIDi509977.
KEGGibta:509977.

Organism-specific databases

CTDi10550.

Phylogenomic databases

eggNOGiKOG4050. Eukaryota.
ENOG4111MUC. LUCA.
GeneTreeiENSGT00390000008631.
HOGENOMiHOG000231363.
HOVERGENiHBG053661.
InParanoidiQ5E9M1.
OMAiISNLMYY.
OrthoDBiEOG7VDXQH.
TreeFamiTF105479.

Enzyme and pathway databases

ReactomeiR-BTA-210500. Glutamate Neurotransmitter Release Cycle.

Family and domain databases

InterProiIPR004895. Prenylated_rab_accept_PRA1.
[Graphical view]
PfamiPF03208. PRA1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiPRAF3_BOVIN
AccessioniPrimary (citable) accession number: Q5E9M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.