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Protein

Claudin-10

Gene

CLDN10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-10
Gene namesi
Name:CLDN10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 12

Organism-specific databases

VGNCiVGNC:27403 CLDN10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 80ExtracellularSequence analysisAdd BLAST59
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 115CytoplasmicSequence analysisAdd BLAST14
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 160ExtracellularSequence analysisAdd BLAST24
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 231CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444181 – 231Claudin-10Add BLAST231

Proteomic databases

PaxDbiQ5E9L0
PRIDEiQ5E9L0

Expressioni

Gene expression databases

BgeeiENSBTAG00000003568

Interactioni

Subunit structurei

Can form homodimers both in trans (interaction between CLDN10 molecules in opposing membranes) and in cis (interaction between CLDN10 molecules within one membrane).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004641

Structurei

3D structure databases

SMRiQ5E9L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The fourth transmembrane region (161-181) is necessary for integration into tight junctions.By similarity

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQ7E Eukaryota
ENOG410YF7U LUCA
GeneTreeiENSGT00760000119222
HOGENOMiHOG000220937
HOVERGENiHBG000643
InParanoidiQ5E9L0
KOiK06087
OMAiGYAYNGA
OrthoDBiEOG091G0MX2
TreeFamiTF331936

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003554 Claudin10
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF13 PTHR12002:SF13, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01383 CLAUDIN10
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5E9L0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTASEIIA FMVSISGWVL VSSTLPTDYW KVSTIDGTVI TTATYWANLW
60 70 80 90 100
KTCVTDSTGV SNCKDFPSML ALDGYIQACR GLMIAAVSLG FFGSIFALIG
110 120 130 140 150
MKCTKVGGSD KAKAKIACLA GIVFILSGLC SMTGCSLYAN KITTEFFDPL
160 170 180 190 200
FVEQKYELGA ALFIGWAGAS LCLIGGVIFC FSISDNNKAP RMGYTYNGAT
210 220 230
SVMSSRTKYH GREGDLKTPN PSKQFDKNAY V
Length:231
Mass (Da):24,761
Last modified:March 15, 2005 - v1
Checksum:i84C4DE6C59DCAF9C
GO
Isoform 2 (identifier: Q5E9L0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MASTASEIIA...KDFPSMLALD → MSRAQISALV...RPHFTIFKVE

Show »
Length:229
Mass (Da):24,482
Checksum:i23E877213C340574
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0535491 – 73MASTA…MLALD → MSRAQISALVFGVGGFGALV AATASNEWKVTTRASSVITA TWVYQGLWMNCAGNALGSFH CRPHFTIFKVE in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020910 mRNA Translation: AAX08927.1
DAAA02034568 Genomic DNA No translation available.
DAAA02034569 Genomic DNA No translation available.
DAAA02034570 Genomic DNA No translation available.
DAAA02034571 Genomic DNA No translation available.
DAAA02034572 Genomic DNA No translation available.
BC153270 mRNA Translation: AAI53271.1
RefSeqiNP_001014857.1, NM_001014857.1 [Q5E9L0-1]
NP_001099079.1, NM_001105609.2 [Q5E9L0-2]
UniGeneiBt.16487

Genome annotation databases

EnsembliENSBTAT00000004641; ENSBTAP00000004641; ENSBTAG00000003568 [Q5E9L0-1]
ENSBTAT00000056559; ENSBTAP00000048962; ENSBTAG00000003568 [Q5E9L0-2]
GeneIDi506545
KEGGibta:506545

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLD10_BOVIN
AccessioniPrimary (citable) accession number: Q5E9L0
Secondary accession number(s): A7Z072
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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