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Protein

Synembryn-A

Gene

RIC8A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Synembryn-A
Alternative name(s):
Protein Ric-8A
Gene namesi
Name:RIC8A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:33961 RIC8A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358891 – 530Synembryn-AAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei435PhosphoserineBy similarity1
Modified residuei440PhosphothreonineBy similarity1
Modified residuei442PhosphothreonineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei527PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5E9J8
PRIDEiQ5E9J8

Expressioni

Gene expression databases

BgeeiENSBTAG00000002042

Interactioni

Subunit structurei

Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002646

Family & Domainsi

Sequence similaritiesi

Belongs to the synembryn family.Curated

Phylogenomic databases

eggNOGiKOG4464 Eukaryota
ENOG410XSCJ LUCA
GeneTreeiENSGT00390000014700
HOGENOMiHOG000236345
HOVERGENiHBG054867
InParanoidiQ5E9J8
OMAiGMSPRGH
OrthoDBiEOG091G07N6
TreeFamiTF314907

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019318 Gua_nucleotide_exch_fac_Ric8
IPR008376 Synembryn
PANTHERiPTHR12425 PTHR12425, 1 hit
PfamiView protein in Pfam
PF10165 Ric8, 1 hit
PRINTSiPR01802 SYNEMBRYN
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q5E9J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRAVADAL ETGEEDVVME ALRAYNRENS QSFTFDDAQQ EDRKRLAKLL
60 70 80 90 100
VSVLEQGLPP SRRVIWLQSI RILSRDRSCL DSFTSRRSLQ ALACYAGISA
110 120 130 140 150
SQGSVPEPLN MDVVLESLKC LCNLVLSSPV AQALAAEAGL VVRLAERVGL
160 170 180 190 200
CRQSSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELQGVR LLTRALELTL
210 220 230 240 250
GMTEGERHPE LLPPQETERA MEILKVLFNI TFDSIKREVD EEDAALYRHL
260 270 280 290 300
GTLLRHCVML AAAGDRTEEL HGHAVNLLGN LPVKCLDVLL TLEPHEGSLE
310 320 330 340 350
FLGVNMDVIR VLLSFMEKRL HQTHRLKESV APVLSVLTEC ARMHRPARKF
360 370 380 390 400
LKAQVLPPLR DVRTRPEVGE LLRNKLVRLM THLDTDVKRV AAEFLFVLCS
410 420 430 440 450
ESVPRFIKYT GYGNAAGLLA ARGLMAGGRP EGQYSEDEDT DTDEYKEAKA
460 470 480 490 500
SINPVTGRVE EKPPNPMEGM TEEQKEHEAM KLVNMFDKLS RHRVIQPMGM
510 520 530
SPRGQLTSLQ DAMCETMEGQ LSSDPDSDPD
Length:530
Mass (Da):59,499
Last modified:March 15, 2005 - v1
Checksum:iF663746DB9F588EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020922 mRNA Translation: AAX08939.1
BC118313 mRNA Translation: AAI18314.1
RefSeqiNP_001015627.1, NM_001015627.2
UniGeneiBt.3803

Genome annotation databases

EnsembliENSBTAT00000002646; ENSBTAP00000002646; ENSBTAG00000002042
GeneIDi521037
KEGGibta:521037

Similar proteinsi

Entry informationi

Entry nameiRIC8A_BOVIN
AccessioniPrimary (citable) accession number: Q5E9J8
Secondary accession number(s): Q17QK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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