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Protein

tRNA-specific adenosine deaminase 2

Gene

DEADC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably participates in deamination of adenosine-34 to inosine in many tRNAs.By similarity

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi71 – 711Zinc; catalyticBy similarity
Active sitei73 – 731Proton donorBy similarity
Metal bindingi107 – 1071Zinc; catalyticBy similarity
Metal bindingi110 – 1101Zinc; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminase 2 (EC:3.5.4.-)
Alternative name(s):
Deaminase domain-containing protein 1
tRNA-specific adenosine-34 deaminase subunit ADAT2
Gene namesi
Name:DEADC1
Synonyms:ADAT2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191tRNA-specific adenosine deaminase 2PRO_0000287652Add
BLAST

Proteomic databases

PaxDbiQ5E9J7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037541.

Structurei

3D structure databases

ProteinModelPortaliQ5E9J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 145126CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1018. Eukaryota.
COG0590. LUCA.
GeneTreeiENSGT00390000000280.
HOGENOMiHOG000085051.
HOVERGENiHBG055246.
InParanoidiQ5E9J7.
KOiK15441.
OMAiINCIDQV.
OrthoDBiEOG7RFTJH.
TreeFamiTF313782.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF14437. MafB19-deam. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E9J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKAGPTAA TDGAYSVSAE ETEKWMEQAM QMAKDALDNT EVPVGCLMVY
60 70 80 90 100
NNEVVGKGRN EVNQTKNATR HAEMVAIDQA LDWCRRRGRS PSEVFEHTVL
110 120 130 140 150
YVTVEPCIMC AAALRLMRIP LVVYGCQNER FGGCGSVLDI ASADLPSTGK
160 170 180 190
PFQCTPGYRA EEAVEMLKTF YKQENPNAPK SKVRKKECHK S
Length:191
Mass (Da):21,127
Last modified:March 15, 2005 - v1
Checksum:i82C3835B676A0037
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020923 mRNA. Translation: AAX08940.1.
RefSeqiNP_001029952.1. NM_001034780.1.
UniGeneiBt.37164.

Genome annotation databases

EnsembliENSBTAT00000037717; ENSBTAP00000037541; ENSBTAG00000026519.
GeneIDi615418.
KEGGibta:615418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020923 mRNA. Translation: AAX08940.1.
RefSeqiNP_001029952.1. NM_001034780.1.
UniGeneiBt.37164.

3D structure databases

ProteinModelPortaliQ5E9J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000037541.

Proteomic databases

PaxDbiQ5E9J7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000037717; ENSBTAP00000037541; ENSBTAG00000026519.
GeneIDi615418.
KEGGibta:615418.

Organism-specific databases

CTDi134637.

Phylogenomic databases

eggNOGiKOG1018. Eukaryota.
COG0590. LUCA.
GeneTreeiENSGT00390000000280.
HOGENOMiHOG000085051.
HOVERGENiHBG055246.
InParanoidiQ5E9J7.
KOiK15441.
OMAiINCIDQV.
OrthoDBiEOG7RFTJH.
TreeFamiTF313782.

Miscellaneous databases

NextBioi20899606.

Family and domain databases

HAMAPiMF_00972. tRNA_aden_deaminase.
InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR016193. Cytidine_deaminase-like.
IPR028883. tRNA_aden_deaminase.
[Graphical view]
PfamiPF14437. MafB19-deam. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiADAT2_BOVIN
AccessioniPrimary (citable) accession number: Q5E9J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 15, 2005
Last modified: May 11, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.