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Q5E9J5

- DHCR7_BOVIN

UniProt

Q5E9J5 - DHCR7_BOVIN

Protein

7-dehydrocholesterol reductase

Gene

DHCR7

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).By similarity

    Catalytic activityi

    Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. 7-dehydrocholesterol reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cholesterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00063.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    7-dehydrocholesterol reductase (EC:1.3.1.21)
    Short name:
    7-DHC reductase
    Alternative name(s):
    Sterol Delta(7)-reductase
    Gene namesi
    Name:DHCR7
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4754757-dehydrocholesterol reductasePRO_0000207501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 20023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 44021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ERG4/ERG24 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72042.
    HOGENOMiHOG000193296.
    HOVERGENiHBG007825.
    InParanoidiQ5E9J5.
    KOiK00213.

    Family and domain databases

    InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
    IPR018083. Sterol_reductase_CS.
    [Graphical view]
    PfamiPF01222. ERG4_ERG24. 1 hit.
    [Graphical view]
    PROSITEiPS01017. STEROL_REDUCT_1. 1 hit.
    PS01018. STEROL_REDUCT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5E9J5-1 [UniParc]FASTAAdd to Basket

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    MAAKSQPSAP KTKSTSGLTN GNAAAQGQWG RAWEVDWFSL ASVIFLLLFA    50
    PFIVYYFIMA CDQYGCSLTV PVADLATGRA RLADIWARTP PVTAKAAQIY 100
    TAWVTLQVLL YMLLPDFCHK FLPGYVGGVQ EGAVTPAGAV NKYEINGLQA 150
    WLLTHLLWFA NAHLLGWFSP TIIFDNWIPL LWCANILGYT VSTFAMVKGY 200
    LFPTDARECK FTGNFFYNYM MGVEFNPRIG KWFDFKLFFN GRPGIVAWTL 250
    INLSFAAKQQ ELYGHVTNSM VLVNILQAIY VLDFFWNETW YLKTIDICHD 300
    HFGWYLGWGD CVWLPYLYTL QGLYLVYHPV QLPTYYALGV LLLGLLGYYI 350
    FRMTNHQKDL FRRTDGRCLI WGRKPKAIEC SYTSADGQRH HSKLLVSGFW 400
    GVARHFNYTG DLMGSLAYCL ACGGGHLLPY FYIIFMAILL THRCLRDEHR 450
    CANKYGRDWE HYTAAVPYRL LPGIF 475
    Length:475
    Mass (Da):54,271
    Last modified:March 15, 2005 - v1
    Checksum:i4712E8DBA76D0A91
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020925 mRNA. Translation: AAX08942.1.
    BC150084 mRNA. Translation: AAI50085.1.
    RefSeqiNP_001014927.1. NM_001014927.1.
    UniGeneiBt.5449.

    Genome annotation databases

    GeneIDi514745.
    KEGGibta:514745.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020925 mRNA. Translation: AAX08942.1 .
    BC150084 mRNA. Translation: AAI50085.1 .
    RefSeqi NP_001014927.1. NM_001014927.1.
    UniGenei Bt.5449.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 514745.
    KEGGi bta:514745.

    Organism-specific databases

    CTDi 1717.

    Phylogenomic databases

    eggNOGi NOG72042.
    HOGENOMi HOG000193296.
    HOVERGENi HBG007825.
    InParanoidi Q5E9J5.
    KOi K00213.

    Enzyme and pathway databases

    UniPathwayi UPA00063 .

    Miscellaneous databases

    NextBioi 20871489.

    Family and domain databases

    InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
    IPR018083. Sterol_reductase_CS.
    [Graphical view ]
    Pfami PF01222. ERG4_ERG24. 1 hit.
    [Graphical view ]
    PROSITEi PS01017. STEROL_REDUCT_1. 1 hit.
    PS01018. STEROL_REDUCT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal skin.

    Entry informationi

    Entry nameiDHCR7_BOVIN
    AccessioniPrimary (citable) accession number: Q5E9J5
    Secondary accession number(s): A6QR24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3