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Q5E9J5 (DHCR7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
7-dehydrocholesterol reductase

Short name=7-DHC reductase
EC=1.3.1.21
Alternative name(s):
Sterol Delta(7)-reductase
Gene names
Name:DHCR7
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.

Catalytic activity

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ERG4/ERG24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4754757-dehydrocholesterol reductase
PRO_0000207501

Regions

Transmembrane40 – 6021Helical; Potential
Transmembrane151 – 17323Helical; Potential
Transmembrane178 – 20023Helical; Potential
Transmembrane266 – 28621Helical; Potential
Transmembrane306 – 32621Helical; Potential
Transmembrane331 – 35121Helical; Potential
Transmembrane420 – 44021Helical; Potential

Amino acid modifications

Modified residue141Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5E9J5 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 4712E8DBA76D0A91

FASTA47554,271
        10         20         30         40         50         60 
MAAKSQPSAP KTKSTSGLTN GNAAAQGQWG RAWEVDWFSL ASVIFLLLFA PFIVYYFIMA 

        70         80         90        100        110        120 
CDQYGCSLTV PVADLATGRA RLADIWARTP PVTAKAAQIY TAWVTLQVLL YMLLPDFCHK 

       130        140        150        160        170        180 
FLPGYVGGVQ EGAVTPAGAV NKYEINGLQA WLLTHLLWFA NAHLLGWFSP TIIFDNWIPL 

       190        200        210        220        230        240 
LWCANILGYT VSTFAMVKGY LFPTDARECK FTGNFFYNYM MGVEFNPRIG KWFDFKLFFN 

       250        260        270        280        290        300 
GRPGIVAWTL INLSFAAKQQ ELYGHVTNSM VLVNILQAIY VLDFFWNETW YLKTIDICHD 

       310        320        330        340        350        360 
HFGWYLGWGD CVWLPYLYTL QGLYLVYHPV QLPTYYALGV LLLGLLGYYI FRMTNHQKDL 

       370        380        390        400        410        420 
FRRTDGRCLI WGRKPKAIEC SYTSADGQRH HSKLLVSGFW GVARHFNYTG DLMGSLAYCL 

       430        440        450        460        470 
ACGGGHLLPY FYIIFMAILL THRCLRDEHR CANKYGRDWE HYTAAVPYRL LPGIF 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT020925 mRNA. Translation: AAX08942.1.
BC150084 mRNA. Translation: AAI50085.1.
RefSeqNP_001014927.1. NM_001014927.1.
UniGeneBt.5449.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID514745.
KEGGbta:514745.

Organism-specific databases

CTD1717.

Phylogenomic databases

eggNOGNOG72042.
HOGENOMHOG000193296.
HOVERGENHBG007825.
InParanoidQ5E9J5.
KOK00213.

Enzyme and pathway databases

UniPathwayUPA00063.

Family and domain databases

InterProIPR001171. Ergosterol_biosynth_ERG4_ERG24.
IPR018083. Sterol_reductase_CS.
[Graphical view]
PfamPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
PROSITEPS01017. STEROL_REDUCT_1. 1 hit.
PS01018. STEROL_REDUCT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20871489.

Entry information

Entry nameDHCR7_BOVIN
AccessionPrimary (citable) accession number: Q5E9J5
Secondary accession number(s): A6QR24
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: March 15, 2005
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways