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Protein

Mycophenolic acid acyl-glucuronide esterase, mitochondrial

Gene

ABHD10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Charge relay systemBy similarity1
Active sitei249Charge relay systemBy similarity1
Active sitei279Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-BTA-156588. Glucuronidation.

Protein family/group databases

ESTHERibovin-q5e9h9. AlphaBeta_hydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC:3.1.1.93)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 10
Short name:
Abhydrolase domain-containing protein 10
Gene namesi
Name:ABHD10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000028073253 – 306Mycophenolic acid acyl-glucuronide esterase, mitochondrialAdd BLAST254

Proteomic databases

PaxDbiQ5E9H9.
PRIDEiQ5E9H9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004601.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006038.

Structurei

3D structure databases

ProteinModelPortaliQ5E9H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 177AB hydrolase-1Sequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IHI0. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00390000017765.
HOGENOMiHOG000139902.
HOVERGENiHBG080562.
InParanoidiQ5E9H9.
KOiK13702.
OMAiYIRFDYS.
OrthoDBiEOG091G0DZV.
TreeFamiTF329757.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVGLAAVP AWVPCRRWGL AAVTFGFHHG LSTLLARKTE RAPQWLRACR
60 70 80 90 100
HKTSISFLSR PDLPNLAYKR LKGKSPGIIF IPGYISNMNG TKALAIEEFC
110 120 130 140 150
KSLGHAYIRF DYSGVGNSDG NLEECTVGKW RKDVLSIIDD LAEGPQILVG
160 170 180 190 200
SSLGGWLMFH AAIARPQKVV ALVGVATAVD GLVTQFNQLP IETKKEIEMK
210 220 230 240 250
GVWPMPSKYS EEGVYRIQYS VIKEAEHHCL LHSPIPVKCP VRLLHGMKDD
260 270 280 290 300
IVPWHTSVQV ADRVVSTDVD VILRKNSDHR MKEKADIQLL VYTIDDLIDK

LSTIVH
Length:306
Mass (Da):33,983
Last modified:March 15, 2005 - v1
Checksum:i13EAC6357029E0C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020941 mRNA. Translation: AAX08958.1.
BC112739 mRNA. Translation: AAI12740.1.
RefSeqiNP_001015606.1. NM_001015606.2.
UniGeneiBt.24834.

Genome annotation databases

EnsembliENSBTAT00000006038; ENSBTAP00000006038; ENSBTAG00000004601.
GeneIDi515563.
KEGGibta:515563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020941 mRNA. Translation: AAX08958.1.
BC112739 mRNA. Translation: AAI12740.1.
RefSeqiNP_001015606.1. NM_001015606.2.
UniGeneiBt.24834.

3D structure databases

ProteinModelPortaliQ5E9H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006038.

Protein family/group databases

ESTHERibovin-q5e9h9. AlphaBeta_hydrolase.

Proteomic databases

PaxDbiQ5E9H9.
PRIDEiQ5E9H9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006038; ENSBTAP00000006038; ENSBTAG00000004601.
GeneIDi515563.
KEGGibta:515563.

Organism-specific databases

CTDi55347.

Phylogenomic databases

eggNOGiENOG410IHI0. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00390000017765.
HOGENOMiHOG000139902.
HOVERGENiHBG080562.
InParanoidiQ5E9H9.
KOiK13702.
OMAiYIRFDYS.
OrthoDBiEOG091G0DZV.
TreeFamiTF329757.

Enzyme and pathway databases

ReactomeiR-BTA-156588. Glucuronidation.

Gene expression databases

BgeeiENSBTAG00000004601.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHDA_BOVIN
AccessioniPrimary (citable) accession number: Q5E9H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.