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Protein

Proteasome activator complex subunit 2

Gene

PSME2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-1169091. Activation of NF-kappaB in B cells.
R-BTA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-BTA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-BTA-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-BTA-174154. APC/C:Cdc20 mediated degradation of Securin.
R-BTA-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-BTA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-BTA-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-BTA-195253. Degradation of beta-catenin by the destruction complex.
R-BTA-202424. Downstream TCR signaling.
R-BTA-2467813. Separation of Sister Chromatids.
R-BTA-2871837. FCERI mediated NF-kB activation.
R-BTA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-BTA-350562. Regulation of ornithine decarboxylase (ODC).
R-BTA-382556. ABC-family proteins mediated transport.
R-BTA-446652. Interleukin-1 family signaling.
R-BTA-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-BTA-4608870. Asymmetric localization of PCP proteins.
R-BTA-4641257. Degradation of AXIN.
R-BTA-4641258. Degradation of DVL.
R-BTA-5358346. Hedgehog ligand biogenesis.
R-BTA-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-BTA-5607764. CLEC7A (Dectin-1) signaling.
R-BTA-5610780. Degradation of GLI1 by the proteasome.
R-BTA-5610785. GLI3 is processed to GLI3R by the proteasome.
R-BTA-5632684. Hedgehog 'on' state.
R-BTA-5658442. Regulation of RAS by GAPs.
R-BTA-5668541. TNFR2 non-canonical NF-kB pathway.
R-BTA-5676590. NIK-->noncanonical NF-kB signaling.
R-BTA-5687128. MAPK6/MAPK4 signaling.
R-BTA-5689603. UCH proteinases.
R-BTA-5689880. Ub-specific processing proteases.
R-BTA-68827. CDT1 association with the CDC6:ORC:origin complex.
R-BTA-68949. Orc1 removal from chromatin.
R-BTA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-BTA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-BTA-69481. G2/M Checkpoints.
R-BTA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-BTA-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-BTA-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-BTA-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs.
R-BTA-8939902. Regulation of RUNX2 expression and activity.
R-BTA-8941858. Regulation of RUNX3 expression and activity.
R-BTA-8948751. Regulation of PTEN stability and activity.
R-BTA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 2
Alternative name(s):
Proteasome activator 28 subunit beta
Short name:
PA28b
Short name:
PA28beta
Gene namesi
Name:PSME2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001617842 – 239Proteasome activator complex subunit 2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei10PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiQ5E9G3.
PRIDEiQ5E9G3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000005814.
ExpressionAtlasiQ5E9G3. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

Protein-protein interaction databases

CORUMiQ5E9G3.

Structurei

3D structure databases

ProteinModelPortaliQ5E9G3.
SMRiQ5E9G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

GeneTreeiENSGT00510000046374.
HOGENOMiHOG000282822.
HOVERGENiHBG053745.
InParanoidiQ5E9G3.
KOiK06697.

Family and domain databases

Gene3Di1.20.120.180. 1 hit.
1.20.5.120. 1 hit.
InterProiView protein in InterPro
IPR003186. PA28_C.
IPR036997. PA28_C_sf.
IPR036996. PA28_N_sf.
IPR009077. Proteasome_activ_PA28.
IPR003185. Proteasome_activ_PA28_N.
IPR036252. Proteasome_activ_sf.
PANTHERiPTHR10660. PTHR10660. 1 hit.
PfamiView protein in Pfam
PF02251. PA28_alpha. 1 hit.
PF02252. PA28_beta. 1 hit.
SUPFAMiSSF47216. SSF47216. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPCGVRLS GEALKQVDVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED
60 70 80 90 100
SFNVTDLNSL RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKV
110 120 130 140 150
LALLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV
160 170 180 190 200
NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAVYG
210 220 230
DLRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY
Length:239
Mass (Da):27,380
Last modified:January 23, 2007 - v3
Checksum:i83CD95CF899C0818
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT020957 mRNA. Translation: AAX08974.1.
BC102583 mRNA. Translation: AAI02584.1.
RefSeqiNP_001014889.1. NM_001014889.1.
UniGeneiBt.48996.

Genome annotation databases

EnsembliENSBTAT00000007642; ENSBTAP00000007642; ENSBTAG00000005814.
GeneIDi509857.
KEGGibta:509857.

Similar proteinsi

Entry informationi

Entry nameiPSME2_BOVIN
AccessioniPrimary (citable) accession number: Q5E9G3
Secondary accession number(s): Q3T038
, Q9TR87, Q9TR88, Q9TR89, Q9TR90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families