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Q5E9G0 (GSTA4_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione S-transferase A4
EC=2.5.1.18
Alternative name(s):
GST class-alpha member 4
Glutathione S-transferase alpha-4
Gene names
Name:GSTA4
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GST superfamily. Alpha family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

xenobiotic metabolic process

Inferred from electronic annotation. Source: Compara

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Glutathione S-transferase A4
PRO_0000249771

Regions

Domain3 – 8381GST N-terminal
Domain85 – 208124GST C-terminal
Region54 – 552Glutathione binding By similarity
Region67 – 682Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5E9G0 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: A0C06C858741A67B

FASTA22225,659
        10         20         30         40         50         60 
MATKPKLHYP NGRGRMESVR WVLAAAGVEF DEEFLETKEQ LQKLQDGNHL LFQQVPMVEI 

        70         80         90        100        110        120 
DGMKLVQTRS ILHYIADKHH LFGKDLKERT LIDMYVEGTL DLLELLIMHP FLKPDDQQKE 

       130        140        150        160        170        180 
VANMAQKAII RYFPVFEKVL RGHGQRFLVG NQLSLADIIL LQTILALEEK IPNILSAFPH 

       190        200        210        220 
LQEYTVKISN IPTIKKFLEP GSKKKPPPDD IYVRTVYNIF MP

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BT020960 mRNA. Translation: AAX08977.1.
IPIIPI00704883.
RefSeqNP_001015651.1. NM_001015651.1.
UniGeneBt.55005.

3D structure databases

HSSPHSSP built from PDB template 1GUL based on UniProtKB O15217.
ProteinModelPortalQ5E9G0.
SMRQ5E9G0. Positions 4-220.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000028640; ENSBTAP00000028640; ENSBTAG00000004288.
GeneID533917.
KEGGbta:533917.

Organism-specific databases

CTD2941.

Phylogenomic databases

eggNOGNOG266414.
GeneTreeENSGT00670000097856.
HOGENOMHOG000115734.
HOVERGENHBG053749.
InParanoidQ5E9G0.
KOK00799.
OMAIIMHPFL.
OrthoDBEOG4N5VXR.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11571:SF4. PTHR11571:SF4. 1 hit.
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01266. GSTRNSFRASEA.
SUPFAMSSF47616. GST_C_like. 1 hit.
SSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20876194.

Entry information

Entry nameGSTA4_BOVIN
AccessionPrimary (citable) accession number: Q5E9G0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 15, 2005
Last modified: April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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