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Q5E9F7

- COF1_BOVIN

UniProt

Q5E9F7 - COF1_BOVIN

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Protein

Cofilin-1

Gene
CFL1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization By similarity. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation By similarity.

GO - Biological processi

  1. actin filament depolymerization Source: InterPro
  2. cytoskeleton organization Source: UniProtKB
  3. establishment of cell polarity Source: Ensembl
  4. neural crest cell migration Source: Ensembl
  5. neural fold formation Source: Ensembl
  6. positive regulation of actin filament depolymerization Source: Ensembl
  7. protein phosphorylation Source: Ensembl
  8. regulation of cell morphogenesis Source: UniProtKB
  9. response to amino acid Source: Ensembl
  10. response to virus Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_205196. Sema3A PAK dependent Axon repulsion.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cofilin-1
Alternative name(s):
Cofilin, non-muscle isoform
Gene namesi
Name:CFL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 29

Subcellular locationi

Nucleus matrix By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionruffle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell projectionlamellipodium membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock By similarity.

GO - Cellular componenti

  1. cortical actin cytoskeleton Source: Ensembl
  2. lamellipodium membrane Source: UniProtKB-SubCell
  3. nuclear matrix Source: UniProtKB-SubCell
  4. ruffle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 166165Cofilin-1PRO_0000214897Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei3 – 31Phosphoserine By similarity
Modified residuei8 – 81Phosphoserine By similarity
Modified residuei13 – 131N6-acetyllysine By similarity
Modified residuei25 – 251Phosphothreonine By similarity
Modified residuei68 – 681Phosphotyrosine By similarity
Modified residuei73 – 731N6-acetyllysine By similarity
Modified residuei140 – 1401Phosphotyrosine By similarity
Modified residuei144 – 1441N6-acetyllysine By similarity
Modified residuei156 – 1561Phosphoserine By similarity

Post-translational modificationi

Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells By similarity. Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal By similarity. Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5E9F7.
PRIDEiQ5E9F7.

Interactioni

Subunit structurei

Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5E9F7.
SMRiQ5E9F7. Positions 1-166.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 153150ADF-HAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 345Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Contains 1 ADF-H domain.

Phylogenomic databases

eggNOGiNOG286948.
GeneTreeiENSGT00440000033289.
HOVERGENiHBG000381.
KOiK05765.
OMAiSKQIHTM.
OrthoDBiEOG7353Z9.
TreeFamiTF328601.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin/Destrin.
IPR027234. Cofilin_1.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PTHR11913:SF17. PTHR11913:SF17. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9F7-1 [UniParc]FASTAAdd to Basket

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MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE    50
EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV 100
FIFWAPECAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA 150
EKLGGSAVIS LEGKPL 166
Length:166
Mass (Da):18,519
Last modified:January 23, 2007 - v3
Checksum:i589EE8EC1ED12719
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020963 mRNA. Translation: AAX08980.1.
BC103077 mRNA. Translation: AAI03078.1.
RefSeqiNP_001015655.1. NM_001015655.1.
UniGeneiBt.52428.

Genome annotation databases

EnsembliENSBTAT00000028602; ENSBTAP00000028602; ENSBTAG00000021455.
GeneIDi534553.
KEGGibta:534553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT020963 mRNA. Translation: AAX08980.1 .
BC103077 mRNA. Translation: AAI03078.1 .
RefSeqi NP_001015655.1. NM_001015655.1.
UniGenei Bt.52428.

3D structure databases

ProteinModelPortali Q5E9F7.
SMRi Q5E9F7. Positions 1-166.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q5E9F7.
PRIDEi Q5E9F7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000028602 ; ENSBTAP00000028602 ; ENSBTAG00000021455 .
GeneIDi 534553.
KEGGi bta:534553.

Organism-specific databases

CTDi 1072.

Phylogenomic databases

eggNOGi NOG286948.
GeneTreei ENSGT00440000033289.
HOVERGENi HBG000381.
KOi K05765.
OMAi SKQIHTM.
OrthoDBi EOG7353Z9.
TreeFami TF328601.

Enzyme and pathway databases

Reactomei REACT_205196. Sema3A PAK dependent Axon repulsion.
REACT_211475. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

NextBioi 20876442.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
InterProi IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin/Destrin.
IPR027234. Cofilin_1.
[Graphical view ]
PANTHERi PTHR11913. PTHR11913. 1 hit.
PTHR11913:SF17. PTHR11913:SF17. 1 hit.
Pfami PF00241. Cofilin_ADF. 1 hit.
[Graphical view ]
PRINTSi PR00006. COFILIN.
SMARTi SM00102. ADF. 1 hit.
[Graphical view ]
PROSITEi PS51263. ADF_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiCOF1_BOVIN
AccessioniPrimary (citable) accession number: Q5E9F7
Secondary accession number(s): Q3SZ74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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