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Q5E9E3

- C1QA_BOVIN

UniProt

Q5E9E3 - C1QA_BOVIN

Protein

Complement C1q subcomponent subunit A

Gene

C1QA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

    GO - Biological processi

    1. complement activation, classical pathway Source: UniProtKB-KW
    2. innate immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Complement pathway, Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C1q subcomponent subunit A
    Gene namesi
    Name:C1QA
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 244222Complement C1q subcomponent subunit APRO_0000003516Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 – 26Interchain (with C-26 in B chain)By similarity
    Modified residuei39 – 3914-hydroxyprolineBy similarity
    Modified residuei45 – 4514-hydroxyprolineBy similarity
    Modified residuei48 – 4815-hydroxylysineBy similarity
    Glycosylationi48 – 481O-linked (Gal...)By similarity
    Modified residuei54 – 5414-hydroxyprolineBy similarity
    Modified residuei57 – 5714-hydroxyprolineBy similarity
    Modified residuei67 – 6715-hydroxylysineBy similarity
    Glycosylationi67 – 671O-linked (Gal...)By similarity
    Modified residuei73 – 7314-hydroxyprolineBy similarity
    Modified residuei79 – 7914-hydroxyprolineBy similarity
    Modified residuei85 – 8514-hydroxyprolineBy similarity
    Modified residuei100 – 10015-hydroxylysineBy similarity
    Glycosylationi100 – 1001O-linked (Gal...)By similarity
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    PRIDEiQ5E9E3.

    Interactioni

    Subunit structurei

    C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5E9E3.
    SMRiQ5E9E3. Positions 112-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 10979Collagen-likeAdd
    BLAST
    Domaini110 – 244135C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG126311.
    GeneTreeiENSGT00750000117378.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiQ5E9E3.
    KOiK03986.
    OMAiYYYFTFQ.
    OrthoDBiEOG70ZZPW.
    TreeFamiTF329591.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5E9E3-1 [UniParc]FASTAAdd to Basket

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    MEAPRGWLVI SVLAISLASS VTEDVCRAPD GTHGSAGIPG RPGRPGLKGE    50
    RGEPGAPAIQ TGIRGLKGDQ GDPGPPGNPG RMGYPGPSGP MGPAGLPGLK 100
    GTKGSPGNIK DQPRPAFSAV GPNSVSRDNV VVFGKVITNQ ENVYQNNTGR 150
    FRCSVPGYYY FTFQVVSNWD ICLSIRSSRR DQIQPLGFCD FNSKGFFQVV 200
    SGGTVLHLQQ GDQVWIEKDP SKGRIYHGSE ADSIFSGFLI FPSA 244
    Length:244
    Mass (Da):25,802
    Last modified:March 15, 2005 - v1
    Checksum:iC7D5B699E501D00D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020977 mRNA. Translation: AAX08994.1.
    AY911382 mRNA. Translation: AAW82145.1.
    BC105345 mRNA. Translation: AAI05346.1.
    RefSeqiNP_001014945.1. NM_001014945.2.
    XP_005203271.1. XM_005203214.1.
    UniGeneiBt.1577.

    Genome annotation databases

    EnsembliENSBTAT00000009415; ENSBTAP00000009415; ENSBTAG00000007153.
    ENSBTAT00000040146; ENSBTAP00000039925; ENSBTAG00000007153.
    GeneIDi534961.
    KEGGibta:534961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT020977 mRNA. Translation: AAX08994.1 .
    AY911382 mRNA. Translation: AAW82145.1 .
    BC105345 mRNA. Translation: AAI05346.1 .
    RefSeqi NP_001014945.1. NM_001014945.2.
    XP_005203271.1. XM_005203214.1.
    UniGenei Bt.1577.

    3D structure databases

    ProteinModelPortali Q5E9E3.
    SMRi Q5E9E3. Positions 112-243.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5E9E3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000009415 ; ENSBTAP00000009415 ; ENSBTAG00000007153 .
    ENSBTAT00000040146 ; ENSBTAP00000039925 ; ENSBTAG00000007153 .
    GeneIDi 534961.
    KEGGi bta:534961.

    Organism-specific databases

    CTDi 712.

    Phylogenomic databases

    eggNOGi NOG126311.
    GeneTreei ENSGT00750000117378.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi Q5E9E3.
    KOi K03986.
    OMAi YYYFTFQ.
    OrthoDBi EOG70ZZPW.
    TreeFami TF329591.

    Miscellaneous databases

    NextBioi 20876583.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
      Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymphoid epithelium.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiC1QA_BOVIN
    AccessioniPrimary (citable) accession number: Q5E9E3
    Secondary accession number(s): Q56JV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3