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Reviewed, UniProtKB/Swiss-Prot Q5E9E3 (C1QA_BOVIN)

Last modified December 15, 2009. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Complement C1q subcomponent subunit A
Gene names
Name: C1QA
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Subunit structure

C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain.

Subcellular location

Secreted.

Post-translational modification

O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups By similarity.

Sequence similarities

Contains 1 C1q domain.

Contains 1 collagen-like domain.

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Ontologies

Keywords
   Biological processComplement pathway
Immune response
Innate immunity
   Cellular componentSecreted
   DomainCollagen
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
Hydroxylation
Gene Ontology (GO)
   Biological processcomplement activation, classical pathway

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 244222Complement C1q subcomponent subunit A
PRO_0000003516

Regions

Domain31 – 10979Collagen-like
Domain110 – 244135C1q

Amino acid modifications

Modified residue3914-hydroxyproline By similarity
Modified residue4514-hydroxyproline By similarity
Modified residue4815-hydroxylysine By similarity
Modified residue5414-hydroxyproline By similarity
Modified residue5714-hydroxyproline By similarity
Modified residue6715-hydroxylysine By similarity
Modified residue7314-hydroxyproline By similarity
Modified residue8514-hydroxyproline By similarity
Modified residue9714-hydroxyproline By similarity
Modified residue10015-hydroxylysine By similarity
Modified residue10315-hydroxylysine By similarity
Glycosylation481O-linked (Gal...) By similarity
Glycosylation671O-linked (Gal...) By similarity
Glycosylation1001O-linked (Gal...) By similarity
Glycosylation1031O-linked (Gal...) By similarity
Glycosylation1461N-linked (GlcNAc...) Potential
Disulfide bond26Interchain (with C-26 in B chain) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5E9E3-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: C7D5B699E501D00D

FASTA24425,802
        10         20         30         40         50         60 
MEAPRGWLVI SVLAISLASS VTEDVCRAPD GTHGSAGIPG RPGRPGLKGE RGEPGAPAIQ 

        70         80         90        100        110        120 
TGIRGLKGDQ GDPGPPGNPG RMGYPGPSGP MGPAGLPGLK GTKGSPGNIK DQPRPAFSAV 

       130        140        150        160        170        180 
GPNSVSRDNV VVFGKVITNQ ENVYQNNTGR FRCSVPGYYY FTFQVVSNWD ICLSIRSSRR 

       190        200        210        220        230        240 
DQIQPLGFCD FNSKGFFQVV SGGTVLHLQQ GDQVWIEKDP SKGRIYHGSE ADSIFSGFLI 


FPSA

« Hide

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References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymphoid epithelium.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.

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Cross-references

Sequence databases

BT020977 mRNA. Translation: AAX08994.1.
AY911382 mRNA. Translation: AAW82145.1.
BC105345 mRNA. Translation: AAI05346.1.
IPIIPI00714861.
RefSeqNP_001014945.1.
UniGeneBt.1577

3D structure databases

SMRQ5E9E3. Positions 112-243.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAT00000009415; ENSBTAP00000009415; ENSBTAG00000007153; Bos taurus. [Genome view]
ENSBTAT00000040146; ENSBTAP00000039925; ENSBTAG00000007153; Bos taurus. [Genome view]
GeneID534961.
KEGGbta:534961.

Organism-specific databases

CTD534961.

Phylogenomic databases

HOVERGENQ5E9E3.
InParanoidQ5E9E3.
OMAGFLIFPS.
OrthoDBEOG9WQ3NX.

Family and domain databases

InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like.
[Graphical view]
Gene3DG3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameC1QA_BOVIN
AccessionPrimary (citable) accession number: Q5E9E3
Secondary accession number(s): Q56JV0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 15, 2005
Last modified: December 15, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents