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Protein

Translation initiation factor eIF-2B subunit beta

Gene

EIF2B2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit beta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit beta
Gene namesi
Name:EIF2B2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Translation initiation factor eIF-2B subunit betaPRO_0000223470Add
BLAST

Proteomic databases

PaxDbiQ5E9B4.
PRIDEiQ5E9B4.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011424.

Structurei

3D structure databases

ProteinModelPortaliQ5E9B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1465. Eukaryota.
COG1184. LUCA.
GeneTreeiENSGT00550000074908.
HOGENOMiHOG000208487.
HOVERGENiHBG051458.
InParanoidiQ5E9B4.
KOiK03754.
OMAiFVSPHEV.
OrthoDBiEOG7N0C4T.
TreeFamiTF101506.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5E9B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAAAKGSE LSERIESFVE ALKRGGGRRS SEDMARETLG LLRRIITDHR
60 70 80 90 100
WSNAGELMEL IRREGRRMTA AQPSETTVGN MVRRVLRIIR EEYGRLHGRS
110 120 130 140 150
DESDQQESLH KLLTSGGLSE DFRSHYAQLQ SNIIEAINEL LVELEGTTEN
160 170 180 190 200
IAAQALEHIH SNEVIMTIGF SRTVEAFLRE AARKRKFHVI VAECAPFCQG
210 220 230 240 250
HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL ANGALRAVAG
260 270 280 290 300
THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG
310 320 330 340 350
DILEKVSVHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPDDHV

L
Length:351
Mass (Da):38,995
Last modified:March 15, 2005 - v1
Checksum:i557604221B37F8A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021006 mRNA. Translation: AAX09023.1.
BC123823 mRNA. Translation: AAI23824.1.
RefSeqiNP_001015593.1. NM_001015593.1.
UniGeneiBt.3050.

Genome annotation databases

EnsembliENSBTAT00000011424; ENSBTAP00000011424; ENSBTAG00000008664.
GeneIDi513958.
KEGGibta:513958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021006 mRNA. Translation: AAX09023.1.
BC123823 mRNA. Translation: AAI23824.1.
RefSeqiNP_001015593.1. NM_001015593.1.
UniGeneiBt.3050.

3D structure databases

ProteinModelPortaliQ5E9B4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011424.

Proteomic databases

PaxDbiQ5E9B4.
PRIDEiQ5E9B4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011424; ENSBTAP00000011424; ENSBTAG00000008664.
GeneIDi513958.
KEGGibta:513958.

Organism-specific databases

CTDi8892.

Phylogenomic databases

eggNOGiKOG1465. Eukaryota.
COG1184. LUCA.
GeneTreeiENSGT00550000074908.
HOGENOMiHOG000208487.
HOVERGENiHBG051458.
InParanoidiQ5E9B4.
KOiK03754.
OMAiFVSPHEV.
OrthoDBiEOG7N0C4T.
TreeFamiTF101506.

Enzyme and pathway databases

ReactomeiR-BTA-72731. Recycling of eIF2:GDP.

Miscellaneous databases

NextBioi20871113.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Brain cortex.

Entry informationi

Entry nameiEI2BB_BOVIN
AccessioniPrimary (citable) accession number: Q5E9B4
Secondary accession number(s): A4FV73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 15, 2005
Last modified: November 11, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.