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Q5E9B3

- PGTB2_BOVIN

UniProt

Q5E9B3 - PGTB2_BOVIN

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Protein
Geranylgeranyl transferase type-2 subunit beta
Gene
RABGGTB
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A By similarity.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Enzyme regulationi

The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi238 – 2381Zinc; catalytic By similarity
Metal bindingi240 – 2401Zinc; catalytic By similarity
Metal bindingi290 – 2901Zinc; via tele nitrogen; catalytic By similarity

GO - Molecular functioni

  1. Rab GTPase binding Source: UniProtKB
  2. Rab geranylgeranyltransferase activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. protein geranylgeranylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name:
GGTase-II-beta
Rab geranyl-geranyltransferase subunit beta
Short name:
Rab GG transferase beta
Short name:
Rab GGTase beta
Rab geranylgeranyltransferase subunit beta
Type II protein geranyl-geranyltransferase subunit beta
Gene namesi
Name:RABGGTB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 331330Geranylgeranyl transferase type-2 subunit beta
PRO_0000244433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity
Modified residuei3 – 31Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ5E9B3.

Interactioni

Subunit structurei

Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5E9B3.
SMRiQ5E9B3. Positions 3-331.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati20 – 6142PFTB 1
Add
BLAST
Repeati68 – 10942PFTB 2
Add
BLAST
Repeati116 – 15742PFTB 3
Add
BLAST
Repeati164 – 20542PFTB 4
Add
BLAST
Repeati212 – 25342PFTB 5
Add
BLAST
Repeati260 – 30243PFTB 6
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1923Geranylgeranyl diphosphate binding By similarity
Regioni232 – 24413Geranylgeranyl diphosphate binding By similarity
Add
BLAST

Sequence similaritiesi

Contains 6 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5029.
HOGENOMiHOG000180334.
HOVERGENiHBG008182.
InParanoidiQ5E9B3.
KOiK05956.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamiPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5E9B3-1 [UniParc]FASTAAdd to Basket

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MGTPQKDVII KSDAPDTLLL EKHADYIASY GSKKDDYEYC MSEYLRMSGI    50
YWGLTVMDLM GQLHRMNREE ILTFIKSCQH ECGGISASIG HDPHLLYTLS 100
AVQILTLYDS INVIDINKVV EYVQSLQKED GSFAGDIWGE IDTRFSFCAV 150
ATLALLGKLD AINVEKAIEF VLSCMNFDGG FGCRPGSESH AGQIYCCTGF 200
LAITSQLHQV NSDLLGWWLC ERQLPSGGLN GRPEKLPDVC YSWWVLASLK 250
IIGRLHWIDR EKLRSFILAC QDEETGGFAD RPGDMVDPFH TLFGIAGLSL 300
LGEEQIKPVS PVFCMPEEVL RRVNVQPELV S 331
Length:331
Mass (Da):36,972
Last modified:March 15, 2005 - v1
Checksum:iCB554CA9B22D334A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021007 mRNA. Translation: AAX09024.1.
BC147953 mRNA. Translation: AAI47954.1.
RefSeqiNP_001015646.1. NM_001015646.1.
UniGeneiBt.20263.

Genome annotation databases

GeneIDi533276.
KEGGibta:533276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT021007 mRNA. Translation: AAX09024.1 .
BC147953 mRNA. Translation: AAI47954.1 .
RefSeqi NP_001015646.1. NM_001015646.1.
UniGenei Bt.20263.

3D structure databases

ProteinModelPortali Q5E9B3.
SMRi Q5E9B3. Positions 3-331.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5E9B3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 533276.
KEGGi bta:533276.

Organism-specific databases

CTDi 5876.

Phylogenomic databases

eggNOGi COG5029.
HOGENOMi HOG000180334.
HOVERGENi HBG008182.
InParanoidi Q5E9B3.
KOi K05956.

Miscellaneous databases

NextBioi 20875982.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
InterProi IPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
PANTHERi PTHR11774:SF9. PTHR11774:SF9. 1 hit.
Pfami PF00432. Prenyltrans. 2 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal medulla.

Entry informationi

Entry nameiPGTB2_BOVIN
AccessioniPrimary (citable) accession number: Q5E9B3
Secondary accession number(s): A6QLG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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